Application of poly(ethylene glycol)– distearoylphosphatidylethanolamine (PEG-DSPE) block copolymers and their derivatives as nanomaterials in drug delivery
Rongrong Wang,1 Renzhong Xiao,2 Zhaowu Zeng,2 Lili Xu,2 Junjie Wang21Campus Hospital of Zhejiang University, 2Research Center for Biomedicine and Health, Hangzhou Normal University, Hangzhou, ChinaAbstract: Poly(ethylene glycol)–distearoylphosphatidylethanolamine (PEG-DSPE) block copol...
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Dove Medical Press
2012
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oai:doaj.org-article:d702f21d1573428392c513449781ea822021-12-02T06:31:18ZApplication of poly(ethylene glycol)– distearoylphosphatidylethanolamine (PEG-DSPE) block copolymers and their derivatives as nanomaterials in drug delivery1176-91141178-2013https://doaj.org/article/d702f21d1573428392c513449781ea822012-08-01T00:00:00Zhttp://www.dovepress.com/application-of-polyethylene-glycolndash-distearoylphosphatidylethanola-a10584https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Rongrong Wang,1 Renzhong Xiao,2 Zhaowu Zeng,2 Lili Xu,2 Junjie Wang21Campus Hospital of Zhejiang University, 2Research Center for Biomedicine and Health, Hangzhou Normal University, Hangzhou, ChinaAbstract: Poly(ethylene glycol)–distearoylphosphatidylethanolamine (PEG-DSPE) block copolymers are biocompatible and amphiphilic polymers that can be widely utilized in the preparation of liposomes, polymeric nanoparticles, polymer hybrid nanoparticles, solid lipid nanoparticles, lipid–polymer hybrid nanoparticles, and microemulsions. Particularly, the terminal groups of PEG can be activated and linked to various targeting ligands, which can prolong the circulation time, improve the drug bioavailability, reduce undesirable side effects, and especially target specific cells, tissues, and even the intracellular localization in organelles. This review herein aims to describe recent developments in drug carriers exploiting PEG-DSPE block copolymers and their derivatives, and the incorporation of different ligands to the end groups of PEG-DSPE to target delivery, focusing on their modification approaches, advantages, applications, and the probable associated drawbacks.Keywords: PEG-DSPE, PEG-lipid, Mal-PEG-DSPE, targeting deliveryWang RXiao RZeng ZXu LWang JDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2012, Iss default, Pp 4185-4198 (2012) |
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Medicine (General) R5-920 |
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Medicine (General) R5-920 Wang R Xiao R Zeng Z Xu L Wang J Application of poly(ethylene glycol)– distearoylphosphatidylethanolamine (PEG-DSPE) block copolymers and their derivatives as nanomaterials in drug delivery |
| description |
Rongrong Wang,1 Renzhong Xiao,2 Zhaowu Zeng,2 Lili Xu,2 Junjie Wang21Campus Hospital of Zhejiang University, 2Research Center for Biomedicine and Health, Hangzhou Normal University, Hangzhou, ChinaAbstract: Poly(ethylene glycol)–distearoylphosphatidylethanolamine (PEG-DSPE) block copolymers are biocompatible and amphiphilic polymers that can be widely utilized in the preparation of liposomes, polymeric nanoparticles, polymer hybrid nanoparticles, solid lipid nanoparticles, lipid–polymer hybrid nanoparticles, and microemulsions. Particularly, the terminal groups of PEG can be activated and linked to various targeting ligands, which can prolong the circulation time, improve the drug bioavailability, reduce undesirable side effects, and especially target specific cells, tissues, and even the intracellular localization in organelles. This review herein aims to describe recent developments in drug carriers exploiting PEG-DSPE block copolymers and their derivatives, and the incorporation of different ligands to the end groups of PEG-DSPE to target delivery, focusing on their modification approaches, advantages, applications, and the probable associated drawbacks.Keywords: PEG-DSPE, PEG-lipid, Mal-PEG-DSPE, targeting delivery |
| format |
article |
| author |
Wang R Xiao R Zeng Z Xu L Wang J |
| author_facet |
Wang R Xiao R Zeng Z Xu L Wang J |
| author_sort |
Wang R |
| title |
Application of poly(ethylene glycol)– distearoylphosphatidylethanolamine (PEG-DSPE) block copolymers and their derivatives as nanomaterials in drug delivery |
| title_short |
Application of poly(ethylene glycol)– distearoylphosphatidylethanolamine (PEG-DSPE) block copolymers and their derivatives as nanomaterials in drug delivery |
| title_full |
Application of poly(ethylene glycol)– distearoylphosphatidylethanolamine (PEG-DSPE) block copolymers and their derivatives as nanomaterials in drug delivery |
| title_fullStr |
Application of poly(ethylene glycol)– distearoylphosphatidylethanolamine (PEG-DSPE) block copolymers and their derivatives as nanomaterials in drug delivery |
| title_full_unstemmed |
Application of poly(ethylene glycol)– distearoylphosphatidylethanolamine (PEG-DSPE) block copolymers and their derivatives as nanomaterials in drug delivery |
| title_sort |
application of poly(ethylene glycol)– distearoylphosphatidylethanolamine (peg-dspe) block copolymers and their derivatives as nanomaterials in drug delivery |
| publisher |
Dove Medical Press |
| publishDate |
2012 |
| url |
https://doaj.org/article/d702f21d1573428392c513449781ea82 |
| work_keys_str_mv |
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