Chronic kidney disease can increase the risk of preoperative deep vein thrombosis in middle-aged and elderly patients with hip fractures

Chronic kidney disease can increase the risk of preoperative deep vein thrombosis in middle-aged and elderly patients with hip fractures

Zhen Wang, Ji Xiao, Zitao Zhang, Xusheng Qiu, Yixin Chen Department of Orthopedics, Drum Tower Hospital Clinical College of Nanjing University, Nanjing, China Background: Preoperative deep vein thrombosis (DVT) is a common complication in patients with hip fractures. Chronic kidney disease (CKD) a...

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Autores principales: Wang Z, Xiao J, Zhang ZT, Qiu XS, Chen YX
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2018
Materias:
CKD
preoperative DVT
hip fractures
middle-aged and elderly patients
Geriatrics
RC952-954.6
Acceso en línea:https://doaj.org/article/d70774a171ce4580bbc1db0aeae4fa2d
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spelling oai:doaj.org-article:d70774a171ce4580bbc1db0aeae4fa2d2021-12-02T04:53:28ZChronic kidney disease can increase the risk of preoperative deep vein thrombosis in middle-aged and elderly patients with hip fractures1178-1998https://doaj.org/article/d70774a171ce4580bbc1db0aeae4fa2d2018-09-01T00:00:00Zhttps://www.dovepress.com/chronic-kidney-disease-can-increase-the-risk-of-preoperative-deep-vein-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Zhen Wang, Ji Xiao, Zitao Zhang, Xusheng Qiu, Yixin Chen Department of Orthopedics, Drum Tower Hospital Clinical College of Nanjing University, Nanjing, China Background: Preoperative deep vein thrombosis (DVT) is a common complication in patients with hip fractures. Chronic kidney disease (CKD) as a frequent comorbidity in middle-aged and elderly patients with hip fractures is known to promote a proinflammatory and prothrombotic state. We aimed to identify whether CKD can increase the risk of DVT in middle-aged and elderly patients with hip fractures, as well as identify other risk factors.Patients and methods: We retrospectively studied 248 middle-aged and elderly patients with hip fractures who were admitted to our hospital from January 2016 to June 2017, meeting all the inclusion criteria. Doppler ultrasonography was used to diagnose DVT. Patients with CKD were classified into five stages according to the Kidney Diseases Outcomes Quality Initiative. We identified whether CKD could increase the occurrence of preoperative DVT in middle-aged and elderly patients with hip fractures and further investigated other independent risk factors for preoperative DVT by using univariate and multivariate analyses.Results: The mean estimated glomerular filtration rate was 125.7±41.4 mL/min/1.73 m2. Briefly, 82.3% (n=204) had been diagnosed with normal kidney function, 11.7% (n=29) with mildly decreased kidney function, and 6.0% (n=15) with stage 3 and 4 CKD. In addition, of the 248 patients, 11.7% (n=29) developed DVT before surgery. Independent predictors of preoperative DVT identified by multivariate analyses were age, prolonged bedridden time, increased levels of fibrinogen, and lower estimated glomerular filtration rate.Conclusion: CKD can increase the risk rate of preoperative DVT in middle-aged and elderly patients with hip fractures. Additionally, age, prolonged bedridden time, and increased levels of fibrinogen were also independent risk factors for preoperative DVT in these patients. We should take preventive measures for these patients with risk factors in order to reduce the incidence of preoperative DVT. Keywords: CKD, preoperative DVT, hip fractures, middle-aged and elderly patientsWang ZXiao JZhang ZTQiu XSChen YXDove Medical PressarticleCKDpreoperative DVThip fracturesmiddle-aged and elderly patientsGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 13, Pp 1669-1674 (2018)
institution DOAJ
collection DOAJ
language EN
topic CKD
preoperative DVT
hip fractures
middle-aged and elderly patients
Geriatrics
RC952-954.6
spellingShingle CKD
preoperative DVT
hip fractures
middle-aged and elderly patients
Geriatrics
RC952-954.6
Wang Z
Xiao J
Zhang ZT
Qiu XS
Chen YX
Chronic kidney disease can increase the risk of preoperative deep vein thrombosis in middle-aged and elderly patients with hip fractures
description Zhen Wang, Ji Xiao, Zitao Zhang, Xusheng Qiu, Yixin Chen Department of Orthopedics, Drum Tower Hospital Clinical College of Nanjing University, Nanjing, China Background: Preoperative deep vein thrombosis (DVT) is a common complication in patients with hip fractures. Chronic kidney disease (CKD) as a frequent comorbidity in middle-aged and elderly patients with hip fractures is known to promote a proinflammatory and prothrombotic state. We aimed to identify whether CKD can increase the risk of DVT in middle-aged and elderly patients with hip fractures, as well as identify other risk factors.Patients and methods: We retrospectively studied 248 middle-aged and elderly patients with hip fractures who were admitted to our hospital from January 2016 to June 2017, meeting all the inclusion criteria. Doppler ultrasonography was used to diagnose DVT. Patients with CKD were classified into five stages according to the Kidney Diseases Outcomes Quality Initiative. We identified whether CKD could increase the occurrence of preoperative DVT in middle-aged and elderly patients with hip fractures and further investigated other independent risk factors for preoperative DVT by using univariate and multivariate analyses.Results: The mean estimated glomerular filtration rate was 125.7±41.4 mL/min/1.73 m2. Briefly, 82.3% (n=204) had been diagnosed with normal kidney function, 11.7% (n=29) with mildly decreased kidney function, and 6.0% (n=15) with stage 3 and 4 CKD. In addition, of the 248 patients, 11.7% (n=29) developed DVT before surgery. Independent predictors of preoperative DVT identified by multivariate analyses were age, prolonged bedridden time, increased levels of fibrinogen, and lower estimated glomerular filtration rate.Conclusion: CKD can increase the risk rate of preoperative DVT in middle-aged and elderly patients with hip fractures. Additionally, age, prolonged bedridden time, and increased levels of fibrinogen were also independent risk factors for preoperative DVT in these patients. We should take preventive measures for these patients with risk factors in order to reduce the incidence of preoperative DVT. Keywords: CKD, preoperative DVT, hip fractures, middle-aged and elderly patients
format article
author Wang Z
Xiao J
Zhang ZT
Qiu XS
Chen YX
author_facet Wang Z
Xiao J
Zhang ZT
Qiu XS
Chen YX
author_sort Wang Z
title Chronic kidney disease can increase the risk of preoperative deep vein thrombosis in middle-aged and elderly patients with hip fractures
title_short Chronic kidney disease can increase the risk of preoperative deep vein thrombosis in middle-aged and elderly patients with hip fractures
title_full Chronic kidney disease can increase the risk of preoperative deep vein thrombosis in middle-aged and elderly patients with hip fractures
title_fullStr Chronic kidney disease can increase the risk of preoperative deep vein thrombosis in middle-aged and elderly patients with hip fractures
title_full_unstemmed Chronic kidney disease can increase the risk of preoperative deep vein thrombosis in middle-aged and elderly patients with hip fractures
title_sort chronic kidney disease can increase the risk of preoperative deep vein thrombosis in middle-aged and elderly patients with hip fractures
publisher Dove Medical Press
publishDate 2018
url https://doaj.org/article/d70774a171ce4580bbc1db0aeae4fa2d
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