MAP1B mutations cause intellectual disability and extensive white matter deficit

Intellectual disability (ID) is characterized by an intelligence quotient of below 70 and impaired adaptive skills. Here, analyzing whole genome sequences from 31,463 Icelanders, Walters et al. identify variants in MAP1B associated with ID and extensive brain-wide white matter deficits.

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Autores principales:	G. Bragi Walters, Omar Gustafsson, Gardar Sveinbjornsson, Valgerdur K. Eiriksdottir, Arna B. Agustsdottir, Gudrun A. Jonsdottir, Stacy Steinberg, Arni F. Gunnarsson, Magnus I. Magnusson, Unnur Unnsteinsdottir, Amy L. Lee, Adalbjorg Jonasdottir, Asgeir Sigurdsson, Aslaug Jonasdottir, Astros Skuladottir, Lina Jonsson, Muhammad S. Nawaz, Patrick Sulem, Mike Frigge, Andres Ingason, Askell Love, Gudmundur L. Norddhal, Mark Zervas, Daniel F. Gudbjartsson, Magnus O. Ulfarsson, Evald Saemundsen, Hreinn Stefansson, Kari Stefansson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d70b7d7d8ac24f859136afd1d51a5234
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spelling	oai:doaj.org-article:d70b7d7d8ac24f859136afd1d51a52342021-12-02T17:32:32ZMAP1B mutations cause intellectual disability and extensive white matter deficit10.1038/s41467-018-05595-62041-1723https://doaj.org/article/d70b7d7d8ac24f859136afd1d51a52342018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05595-6https://doaj.org/toc/2041-1723Intellectual disability (ID) is characterized by an intelligence quotient of below 70 and impaired adaptive skills. Here, analyzing whole genome sequences from 31,463 Icelanders, Walters et al. identify variants in MAP1B associated with ID and extensive brain-wide white matter deficits.G. Bragi WaltersOmar GustafssonGardar SveinbjornssonValgerdur K. EiriksdottirArna B. AgustsdottirGudrun A. JonsdottirStacy SteinbergArni F. GunnarssonMagnus I. MagnussonUnnur UnnsteinsdottirAmy L. LeeAdalbjorg JonasdottirAsgeir SigurdssonAslaug JonasdottirAstros SkuladottirLina JonssonMuhammad S. NawazPatrick SulemMike FriggeAndres IngasonAskell LoveGudmundur L. NorddhalMark ZervasDaniel F. GudbjartssonMagnus O. UlfarssonEvald SaemundsenHreinn StefanssonKari StefanssonNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q G. Bragi Walters Omar Gustafsson Gardar Sveinbjornsson Valgerdur K. Eiriksdottir Arna B. Agustsdottir Gudrun A. Jonsdottir Stacy Steinberg Arni F. Gunnarsson Magnus I. Magnusson Unnur Unnsteinsdottir Amy L. Lee Adalbjorg Jonasdottir Asgeir Sigurdsson Aslaug Jonasdottir Astros Skuladottir Lina Jonsson Muhammad S. Nawaz Patrick Sulem Mike Frigge Andres Ingason Askell Love Gudmundur L. Norddhal Mark Zervas Daniel F. Gudbjartsson Magnus O. Ulfarsson Evald Saemundsen Hreinn Stefansson Kari Stefansson MAP1B mutations cause intellectual disability and extensive white matter deficit
description	Intellectual disability (ID) is characterized by an intelligence quotient of below 70 and impaired adaptive skills. Here, analyzing whole genome sequences from 31,463 Icelanders, Walters et al. identify variants in MAP1B associated with ID and extensive brain-wide white matter deficits.
format	article
author	G. Bragi Walters Omar Gustafsson Gardar Sveinbjornsson Valgerdur K. Eiriksdottir Arna B. Agustsdottir Gudrun A. Jonsdottir Stacy Steinberg Arni F. Gunnarsson Magnus I. Magnusson Unnur Unnsteinsdottir Amy L. Lee Adalbjorg Jonasdottir Asgeir Sigurdsson Aslaug Jonasdottir Astros Skuladottir Lina Jonsson Muhammad S. Nawaz Patrick Sulem Mike Frigge Andres Ingason Askell Love Gudmundur L. Norddhal Mark Zervas Daniel F. Gudbjartsson Magnus O. Ulfarsson Evald Saemundsen Hreinn Stefansson Kari Stefansson
author_facet	G. Bragi Walters Omar Gustafsson Gardar Sveinbjornsson Valgerdur K. Eiriksdottir Arna B. Agustsdottir Gudrun A. Jonsdottir Stacy Steinberg Arni F. Gunnarsson Magnus I. Magnusson Unnur Unnsteinsdottir Amy L. Lee Adalbjorg Jonasdottir Asgeir Sigurdsson Aslaug Jonasdottir Astros Skuladottir Lina Jonsson Muhammad S. Nawaz Patrick Sulem Mike Frigge Andres Ingason Askell Love Gudmundur L. Norddhal Mark Zervas Daniel F. Gudbjartsson Magnus O. Ulfarsson Evald Saemundsen Hreinn Stefansson Kari Stefansson
author_sort	G. Bragi Walters
title	MAP1B mutations cause intellectual disability and extensive white matter deficit
title_short	MAP1B mutations cause intellectual disability and extensive white matter deficit
title_full	MAP1B mutations cause intellectual disability and extensive white matter deficit
title_fullStr	MAP1B mutations cause intellectual disability and extensive white matter deficit
title_full_unstemmed	MAP1B mutations cause intellectual disability and extensive white matter deficit
title_sort	map1b mutations cause intellectual disability and extensive white matter deficit
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/d70b7d7d8ac24f859136afd1d51a5234
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MAP1B mutations cause intellectual disability and extensive white matter deficit

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