Low serum calcium is associated with higher long-term mortality in myocardial infarction patients from a population-based registry

Abstract Calcium plays an essential role in physiology of the cardiovascular system. Aberrations from normal serum calcium levels are known to be associated with several cardiovascular diseases. Its possible role as a predictor for long-term mortality after acute myocardial infarction (AMI) is still...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Timo Schmitz, Christian Thilo, Jakob Linseisen, Margit Heier, Annette Peters, Bernhard Kuch, Christa Meisinger
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d70c799996184ecfbaae8749c55154b0
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d70c799996184ecfbaae8749c55154b0
record_format	dspace
spelling	oai:doaj.org-article:d70c799996184ecfbaae8749c55154b02021-12-02T13:57:58ZLow serum calcium is associated with higher long-term mortality in myocardial infarction patients from a population-based registry10.1038/s41598-021-81929-72045-2322https://doaj.org/article/d70c799996184ecfbaae8749c55154b02021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81929-7https://doaj.org/toc/2045-2322Abstract Calcium plays an essential role in physiology of the cardiovascular system. Aberrations from normal serum calcium levels are known to be associated with several cardiovascular diseases. Its possible role as a predictor for long-term mortality after acute myocardial infarction (AMI) is still uncertain. In this study, a total of 3732 patients (aged 25–74 years) with incident AMI surviving at least 28 days after AMI was included. The median follow-up time was 6.0 years. Admission total serum calcium levels were divided into quartiles. The Kaplan–Meier-Curve suggested a division of the follow up time in two different time periods. So, Cox regression models were calculated to assess association between admission serum calcium levels and all-cause long-term mortality with two observation periods: 28–2500 days and > 2500 days. The final model was adjusted for various comorbidities, clinical characteristics, in-hospital treatment and medication. The third quartile (normal-high Calcium levels) served as the reference group. The fully adjusted Cox-regression model shows significantly higher mortality risk for low serum calcium (quartile 1) within the timeframe 28–2500 days after the event (OR 1.53 [1.19–1.98]). The other groups did not differ significantly from each other. In the later observation period (from 2500 days until death or censoring) no more significant differences were seen between the four calcium quartiles. In summary, low serum calcium is an independent predictor of adverse outcome in the first 2500 days (about 7 years) after AMI. On later points in time this effect attenuates, so that no more significant differences can be observed.Timo SchmitzChristian ThiloJakob LinseisenMargit HeierAnnette PetersBernhard KuchChrista MeisingerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Timo Schmitz Christian Thilo Jakob Linseisen Margit Heier Annette Peters Bernhard Kuch Christa Meisinger Low serum calcium is associated with higher long-term mortality in myocardial infarction patients from a population-based registry
description	Abstract Calcium plays an essential role in physiology of the cardiovascular system. Aberrations from normal serum calcium levels are known to be associated with several cardiovascular diseases. Its possible role as a predictor for long-term mortality after acute myocardial infarction (AMI) is still uncertain. In this study, a total of 3732 patients (aged 25–74 years) with incident AMI surviving at least 28 days after AMI was included. The median follow-up time was 6.0 years. Admission total serum calcium levels were divided into quartiles. The Kaplan–Meier-Curve suggested a division of the follow up time in two different time periods. So, Cox regression models were calculated to assess association between admission serum calcium levels and all-cause long-term mortality with two observation periods: 28–2500 days and > 2500 days. The final model was adjusted for various comorbidities, clinical characteristics, in-hospital treatment and medication. The third quartile (normal-high Calcium levels) served as the reference group. The fully adjusted Cox-regression model shows significantly higher mortality risk for low serum calcium (quartile 1) within the timeframe 28–2500 days after the event (OR 1.53 [1.19–1.98]). The other groups did not differ significantly from each other. In the later observation period (from 2500 days until death or censoring) no more significant differences were seen between the four calcium quartiles. In summary, low serum calcium is an independent predictor of adverse outcome in the first 2500 days (about 7 years) after AMI. On later points in time this effect attenuates, so that no more significant differences can be observed.
format	article
author	Timo Schmitz Christian Thilo Jakob Linseisen Margit Heier Annette Peters Bernhard Kuch Christa Meisinger
author_facet	Timo Schmitz Christian Thilo Jakob Linseisen Margit Heier Annette Peters Bernhard Kuch Christa Meisinger
author_sort	Timo Schmitz
title	Low serum calcium is associated with higher long-term mortality in myocardial infarction patients from a population-based registry
title_short	Low serum calcium is associated with higher long-term mortality in myocardial infarction patients from a population-based registry
title_full	Low serum calcium is associated with higher long-term mortality in myocardial infarction patients from a population-based registry
title_fullStr	Low serum calcium is associated with higher long-term mortality in myocardial infarction patients from a population-based registry
title_full_unstemmed	Low serum calcium is associated with higher long-term mortality in myocardial infarction patients from a population-based registry
title_sort	low serum calcium is associated with higher long-term mortality in myocardial infarction patients from a population-based registry
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d70c799996184ecfbaae8749c55154b0
work_keys_str_mv	AT timoschmitz lowserumcalciumisassociatedwithhigherlongtermmortalityinmyocardialinfarctionpatientsfromapopulationbasedregistry AT christianthilo lowserumcalciumisassociatedwithhigherlongtermmortalityinmyocardialinfarctionpatientsfromapopulationbasedregistry AT jakoblinseisen lowserumcalciumisassociatedwithhigherlongtermmortalityinmyocardialinfarctionpatientsfromapopulationbasedregistry AT margitheier lowserumcalciumisassociatedwithhigherlongtermmortalityinmyocardialinfarctionpatientsfromapopulationbasedregistry AT annettepeters lowserumcalciumisassociatedwithhigherlongtermmortalityinmyocardialinfarctionpatientsfromapopulationbasedregistry AT bernhardkuch lowserumcalciumisassociatedwithhigherlongtermmortalityinmyocardialinfarctionpatientsfromapopulationbasedregistry AT christameisinger lowserumcalciumisassociatedwithhigherlongtermmortalityinmyocardialinfarctionpatientsfromapopulationbasedregistry
_version_	1718392289469923328

Low serum calcium is associated with higher long-term mortality in myocardial infarction patients from a population-based registry

Ejemplares similares