COMPARISON OF THE PRIMARY AND SECONDARY HUMORAL IMMUNE RESPONSE TO VACCINATION BY “PRIORIX”

Abstract. Twenty healthy children were vaccinated, and then in a 5 years they were revaccinated with Priorix (measles, mumps, rubella vaccine), according to the national immunization calendar. The aim of the study was to observe and compare the shaping and maintenance of immunological memory. Specif...

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Autores principales:	A. P. Toptygina, V. A. Alioshkin
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2014
Materias:	measles rubella mumps immune response specific antibodies vaccination priorix Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/d70f55a805514d55a17ca3da56e2b35c
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spelling	oai:doaj.org-article:d70f55a805514d55a17ca3da56e2b35c2021-11-22T07:09:46ZCOMPARISON OF THE PRIMARY AND SECONDARY HUMORAL IMMUNE RESPONSE TO VACCINATION BY “PRIORIX”2220-76192313-739810.15789/2220-7619-2013-4-359-364https://doaj.org/article/d70f55a805514d55a17ca3da56e2b35c2014-07-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/148https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398Abstract. Twenty healthy children were vaccinated, and then in a 5 years they were revaccinated with Priorix (measles, mumps, rubella vaccine), according to the national immunization calendar. The aim of the study was to observe and compare the shaping and maintenance of immunological memory. Specific IgM, IgA, IgG antibodies in serum, and their subclasses as well as antibodies avidity were tested by ELISA. It was demonstrated that IgM, IgG, and IgA antibodies shaped primary immune response to Priorix. Booster-effect was found in IgG and IgA antibodies in response to revaccination. Low avidity of antibodies in primary immune response changed to the high avidity (60–70%) antibodies of memory response to measles and rubella, and remained low for antimumps antibodies. IgG3 subclass was predominant, and IgG1 and IgG4 subclasses were involved in primary immune response. At the stage of immunological memory IgG1 was predominanted and IgG3 and IgG4 became minor.A. P. ToptyginaV. A. AlioshkinSankt-Peterburg : NIIÈM imeni Pasteraarticlemeaslesrubellamumpsimmune responsespecific antibodiesvaccinationpriorixInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 3, Iss 4, Pp 359-364 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	measles rubella mumps immune response specific antibodies vaccination priorix Infectious and parasitic diseases RC109-216
spellingShingle	measles rubella mumps immune response specific antibodies vaccination priorix Infectious and parasitic diseases RC109-216 A. P. Toptygina V. A. Alioshkin COMPARISON OF THE PRIMARY AND SECONDARY HUMORAL IMMUNE RESPONSE TO VACCINATION BY “PRIORIX”
description	Abstract. Twenty healthy children were vaccinated, and then in a 5 years they were revaccinated with Priorix (measles, mumps, rubella vaccine), according to the national immunization calendar. The aim of the study was to observe and compare the shaping and maintenance of immunological memory. Specific IgM, IgA, IgG antibodies in serum, and their subclasses as well as antibodies avidity were tested by ELISA. It was demonstrated that IgM, IgG, and IgA antibodies shaped primary immune response to Priorix. Booster-effect was found in IgG and IgA antibodies in response to revaccination. Low avidity of antibodies in primary immune response changed to the high avidity (60–70%) antibodies of memory response to measles and rubella, and remained low for antimumps antibodies. IgG3 subclass was predominant, and IgG1 and IgG4 subclasses were involved in primary immune response. At the stage of immunological memory IgG1 was predominanted and IgG3 and IgG4 became minor.
format	article
author	A. P. Toptygina V. A. Alioshkin
author_facet	A. P. Toptygina V. A. Alioshkin
author_sort	A. P. Toptygina
title	COMPARISON OF THE PRIMARY AND SECONDARY HUMORAL IMMUNE RESPONSE TO VACCINATION BY “PRIORIX”
title_short	COMPARISON OF THE PRIMARY AND SECONDARY HUMORAL IMMUNE RESPONSE TO VACCINATION BY “PRIORIX”
title_full	COMPARISON OF THE PRIMARY AND SECONDARY HUMORAL IMMUNE RESPONSE TO VACCINATION BY “PRIORIX”
title_fullStr	COMPARISON OF THE PRIMARY AND SECONDARY HUMORAL IMMUNE RESPONSE TO VACCINATION BY “PRIORIX”
title_full_unstemmed	COMPARISON OF THE PRIMARY AND SECONDARY HUMORAL IMMUNE RESPONSE TO VACCINATION BY “PRIORIX”
title_sort	comparison of the primary and secondary humoral immune response to vaccination by “priorix”
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2014
url	https://doaj.org/article/d70f55a805514d55a17ca3da56e2b35c
work_keys_str_mv	AT aptoptygina comparisonoftheprimaryandsecondaryhumoralimmuneresponsetovaccinationbypriorix AT vaalioshkin comparisonoftheprimaryandsecondaryhumoralimmuneresponsetovaccinationbypriorix
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COMPARISON OF THE PRIMARY AND SECONDARY HUMORAL IMMUNE RESPONSE TO VACCINATION BY “PRIORIX”

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