Discovery of gramicidin A analogues with altered activities by multidimensional screening of a one-bead-one-compound library

The strong hemolytic activity and mammalian cytotoxicity of gramicidin A, a peptide antibiotic, has hindered its non-topical clinical application. Here, the authors report a high-throughput strategy for the discovery of gramicidin A analogues with altered biological activity profiles.

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Autores principales:	Yuri Takada, Hiroaki Itoh, Atmika Paudel, Suresh Panthee, Hiroshi Hamamoto, Kazuhisa Sekimizu, Masayuki Inoue
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d70f64d57774438f93c1663567f9fba6
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spelling	oai:doaj.org-article:d70f64d57774438f93c1663567f9fba62021-12-02T17:18:12ZDiscovery of gramicidin A analogues with altered activities by multidimensional screening of a one-bead-one-compound library10.1038/s41467-020-18711-22041-1723https://doaj.org/article/d70f64d57774438f93c1663567f9fba62020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18711-2https://doaj.org/toc/2041-1723The strong hemolytic activity and mammalian cytotoxicity of gramicidin A, a peptide antibiotic, has hindered its non-topical clinical application. Here, the authors report a high-throughput strategy for the discovery of gramicidin A analogues with altered biological activity profiles.Yuri TakadaHiroaki ItohAtmika PaudelSuresh PantheeHiroshi HamamotoKazuhisa SekimizuMasayuki InoueNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yuri Takada Hiroaki Itoh Atmika Paudel Suresh Panthee Hiroshi Hamamoto Kazuhisa Sekimizu Masayuki Inoue Discovery of gramicidin A analogues with altered activities by multidimensional screening of a one-bead-one-compound library
description	The strong hemolytic activity and mammalian cytotoxicity of gramicidin A, a peptide antibiotic, has hindered its non-topical clinical application. Here, the authors report a high-throughput strategy for the discovery of gramicidin A analogues with altered biological activity profiles.
format	article
author	Yuri Takada Hiroaki Itoh Atmika Paudel Suresh Panthee Hiroshi Hamamoto Kazuhisa Sekimizu Masayuki Inoue
author_facet	Yuri Takada Hiroaki Itoh Atmika Paudel Suresh Panthee Hiroshi Hamamoto Kazuhisa Sekimizu Masayuki Inoue
author_sort	Yuri Takada
title	Discovery of gramicidin A analogues with altered activities by multidimensional screening of a one-bead-one-compound library
title_short	Discovery of gramicidin A analogues with altered activities by multidimensional screening of a one-bead-one-compound library
title_full	Discovery of gramicidin A analogues with altered activities by multidimensional screening of a one-bead-one-compound library
title_fullStr	Discovery of gramicidin A analogues with altered activities by multidimensional screening of a one-bead-one-compound library
title_full_unstemmed	Discovery of gramicidin A analogues with altered activities by multidimensional screening of a one-bead-one-compound library
title_sort	discovery of gramicidin a analogues with altered activities by multidimensional screening of a one-bead-one-compound library
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/d70f64d57774438f93c1663567f9fba6
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Discovery of gramicidin A analogues with altered activities by multidimensional screening of a one-bead-one-compound library

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