Defective viral genomes as therapeutic interfering particles against flavivirus infection in mammalian and mosquito hosts

Defective viral genomes as therapeutic interfering particles against flavivirus infection in mammalian and mosquito hosts

Defective viral genomes (DVGs) can interfere with virus replication and provide a potential approach to control infection. Here, Rezelj et al. use a combined experimental evolution and computational approach to identify DVG sequences that optimally interfere with Zika virus infection and show antivi...

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Autores principales: Veronica V. Rezelj, Lucía Carrau, Fernando Merwaiss, Laura I. Levi, Diana Erazo, Quang Dinh Tran, Annabelle Henrion-Lacritick, Valérie Gausson, Yasutsugu Suzuki, Djoshkun Shengjuler, Bjoern Meyer, Thomas Vallet, James Weger-Lucarelli, Veronika Bernhauerová, Avi Titievsky, Vadim Sharov, Stefano Pietropaoli, Marco A. Diaz-Salinas, Vincent Legros, Nathalie Pardigon, Giovanna Barba-Spaeth, Leonid Brodsky, Maria-Carla Saleh, Marco Vignuzzi
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/d70fcdc44d394752b4d2a35629bb2bcf
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spelling oai:doaj.org-article:d70fcdc44d394752b4d2a35629bb2bcf2021-12-02T14:30:27ZDefective viral genomes as therapeutic interfering particles against flavivirus infection in mammalian and mosquito hosts10.1038/s41467-021-22341-72041-1723https://doaj.org/article/d70fcdc44d394752b4d2a35629bb2bcf2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22341-7https://doaj.org/toc/2041-1723Defective viral genomes (DVGs) can interfere with virus replication and provide a potential approach to control infection. Here, Rezelj et al. use a combined experimental evolution and computational approach to identify DVG sequences that optimally interfere with Zika virus infection and show antiviral activity in mice and mosquitoes.Veronica V. RezeljLucía CarrauFernando MerwaissLaura I. LeviDiana ErazoQuang Dinh TranAnnabelle Henrion-LacritickValérie GaussonYasutsugu SuzukiDjoshkun ShengjulerBjoern MeyerThomas ValletJames Weger-LucarelliVeronika BernhauerováAvi TitievskyVadim SharovStefano PietropaoliMarco A. Diaz-SalinasVincent LegrosNathalie PardigonGiovanna Barba-SpaethLeonid BrodskyMaria-Carla SalehMarco VignuzziNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Veronica V. Rezelj
Lucía Carrau
Fernando Merwaiss
Laura I. Levi
Diana Erazo
Quang Dinh Tran
Annabelle Henrion-Lacritick
Valérie Gausson
Yasutsugu Suzuki
Djoshkun Shengjuler
Bjoern Meyer
Thomas Vallet
James Weger-Lucarelli
Veronika Bernhauerová
Avi Titievsky
Vadim Sharov
Stefano Pietropaoli
Marco A. Diaz-Salinas
Vincent Legros
Nathalie Pardigon
Giovanna Barba-Spaeth
Leonid Brodsky
Maria-Carla Saleh
Marco Vignuzzi
Defective viral genomes as therapeutic interfering particles against flavivirus infection in mammalian and mosquito hosts
description Defective viral genomes (DVGs) can interfere with virus replication and provide a potential approach to control infection. Here, Rezelj et al. use a combined experimental evolution and computational approach to identify DVG sequences that optimally interfere with Zika virus infection and show antiviral activity in mice and mosquitoes.
format article
author Veronica V. Rezelj
Lucía Carrau
Fernando Merwaiss
Laura I. Levi
Diana Erazo
Quang Dinh Tran
Annabelle Henrion-Lacritick
Valérie Gausson
Yasutsugu Suzuki
Djoshkun Shengjuler
Bjoern Meyer
Thomas Vallet
James Weger-Lucarelli
Veronika Bernhauerová
Avi Titievsky
Vadim Sharov
Stefano Pietropaoli
Marco A. Diaz-Salinas
Vincent Legros
Nathalie Pardigon
Giovanna Barba-Spaeth
Leonid Brodsky
Maria-Carla Saleh
Marco Vignuzzi
author_facet Veronica V. Rezelj
Lucía Carrau
Fernando Merwaiss
Laura I. Levi
Diana Erazo
Quang Dinh Tran
Annabelle Henrion-Lacritick
Valérie Gausson
Yasutsugu Suzuki
Djoshkun Shengjuler
Bjoern Meyer
Thomas Vallet
James Weger-Lucarelli
Veronika Bernhauerová
Avi Titievsky
Vadim Sharov
Stefano Pietropaoli
Marco A. Diaz-Salinas
Vincent Legros
Nathalie Pardigon
Giovanna Barba-Spaeth
Leonid Brodsky
Maria-Carla Saleh
Marco Vignuzzi
author_sort Veronica V. Rezelj
title Defective viral genomes as therapeutic interfering particles against flavivirus infection in mammalian and mosquito hosts
title_short Defective viral genomes as therapeutic interfering particles against flavivirus infection in mammalian and mosquito hosts
title_full Defective viral genomes as therapeutic interfering particles against flavivirus infection in mammalian and mosquito hosts
title_fullStr Defective viral genomes as therapeutic interfering particles against flavivirus infection in mammalian and mosquito hosts
title_full_unstemmed Defective viral genomes as therapeutic interfering particles against flavivirus infection in mammalian and mosquito hosts
title_sort defective viral genomes as therapeutic interfering particles against flavivirus infection in mammalian and mosquito hosts
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/d70fcdc44d394752b4d2a35629bb2bcf
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