Impact of bleeding during dual antiplatelet therapy in patients with coronary artery disease

Abstract This nationwide retrospective cohort study used the National Health Insurance Research Database of Taiwan to compare the impact of bleeding on clinical outcomes in patients with acute myocardial infarction (AMI) versus chronic coronary syndrome (CCS). Between July 2007 and December 2010, pa...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ying-Chang Tung, Lai-Chu See, Shu-Hao Chang, Jia-Rou Liu, Chi-Tai Kuo, Chi-Jen Chang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d712270185d34c808b41d127b098eaf3
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d712270185d34c808b41d127b098eaf3
record_format	dspace
spelling	oai:doaj.org-article:d712270185d34c808b41d127b098eaf32021-12-02T12:33:53ZImpact of bleeding during dual antiplatelet therapy in patients with coronary artery disease10.1038/s41598-020-78400-42045-2322https://doaj.org/article/d712270185d34c808b41d127b098eaf32020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78400-4https://doaj.org/toc/2045-2322Abstract This nationwide retrospective cohort study used the National Health Insurance Research Database of Taiwan to compare the impact of bleeding on clinical outcomes in patients with acute myocardial infarction (AMI) versus chronic coronary syndrome (CCS). Between July 2007 and December 2010, patients with AMI (n = 15,391) and CCS (n = 19,724) who received dual antiplatelet therapy after coronary stenting were identified from the database. AMI was associated with increased risks of MI (AMI vs. CCS: 0.38 vs. 0.16 per 100 patient-months; p < 0.01), all-cause death (0.49 vs. 0.32 per 100 patient-months; p < 0.01), and BARC type 3 bleeding (0.22 vs. 0.13 per 100 patient-months; p < 0.01) at 1 year compared with CCS, while the risk of BARC type 2 bleeding was marginally higher in the CCS patients than in the AMI patients (1.32 vs. 1.4 per 100 person-months; p = 0.06). Bleeding was an independent predictor of MI, stroke, and all-cause death in this East Asian population, regardless of the initial presentation. Among the patients with bleeding, AMI was associated with a higher risk of ischemic events at 1 year after bleeding compared with CCS (MI: 0.34 vs. 0.25 per 100 patient-months; p = 0.06; ischemic stroke: 0.22 vs. 0.13 per 100 patient-months; p = 0.02). The 1-year mortality after bleeding was comparable between the two groups after propensity score weighting. In conclusion, bleeding conferred an increased risk of adverse outcomes in East Asian patients with AMI and CCS.Ying-Chang TungLai-Chu SeeShu-Hao ChangJia-Rou LiuChi-Tai KuoChi-Jen ChangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ying-Chang Tung Lai-Chu See Shu-Hao Chang Jia-Rou Liu Chi-Tai Kuo Chi-Jen Chang Impact of bleeding during dual antiplatelet therapy in patients with coronary artery disease
description	Abstract This nationwide retrospective cohort study used the National Health Insurance Research Database of Taiwan to compare the impact of bleeding on clinical outcomes in patients with acute myocardial infarction (AMI) versus chronic coronary syndrome (CCS). Between July 2007 and December 2010, patients with AMI (n = 15,391) and CCS (n = 19,724) who received dual antiplatelet therapy after coronary stenting were identified from the database. AMI was associated with increased risks of MI (AMI vs. CCS: 0.38 vs. 0.16 per 100 patient-months; p < 0.01), all-cause death (0.49 vs. 0.32 per 100 patient-months; p < 0.01), and BARC type 3 bleeding (0.22 vs. 0.13 per 100 patient-months; p < 0.01) at 1 year compared with CCS, while the risk of BARC type 2 bleeding was marginally higher in the CCS patients than in the AMI patients (1.32 vs. 1.4 per 100 person-months; p = 0.06). Bleeding was an independent predictor of MI, stroke, and all-cause death in this East Asian population, regardless of the initial presentation. Among the patients with bleeding, AMI was associated with a higher risk of ischemic events at 1 year after bleeding compared with CCS (MI: 0.34 vs. 0.25 per 100 patient-months; p = 0.06; ischemic stroke: 0.22 vs. 0.13 per 100 patient-months; p = 0.02). The 1-year mortality after bleeding was comparable between the two groups after propensity score weighting. In conclusion, bleeding conferred an increased risk of adverse outcomes in East Asian patients with AMI and CCS.
format	article
author	Ying-Chang Tung Lai-Chu See Shu-Hao Chang Jia-Rou Liu Chi-Tai Kuo Chi-Jen Chang
author_facet	Ying-Chang Tung Lai-Chu See Shu-Hao Chang Jia-Rou Liu Chi-Tai Kuo Chi-Jen Chang
author_sort	Ying-Chang Tung
title	Impact of bleeding during dual antiplatelet therapy in patients with coronary artery disease
title_short	Impact of bleeding during dual antiplatelet therapy in patients with coronary artery disease
title_full	Impact of bleeding during dual antiplatelet therapy in patients with coronary artery disease
title_fullStr	Impact of bleeding during dual antiplatelet therapy in patients with coronary artery disease
title_full_unstemmed	Impact of bleeding during dual antiplatelet therapy in patients with coronary artery disease
title_sort	impact of bleeding during dual antiplatelet therapy in patients with coronary artery disease
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/d712270185d34c808b41d127b098eaf3
work_keys_str_mv	AT yingchangtung impactofbleedingduringdualantiplatelettherapyinpatientswithcoronaryarterydisease AT laichusee impactofbleedingduringdualantiplatelettherapyinpatientswithcoronaryarterydisease AT shuhaochang impactofbleedingduringdualantiplatelettherapyinpatientswithcoronaryarterydisease AT jiarouliu impactofbleedingduringdualantiplatelettherapyinpatientswithcoronaryarterydisease AT chitaikuo impactofbleedingduringdualantiplatelettherapyinpatientswithcoronaryarterydisease AT chijenchang impactofbleedingduringdualantiplatelettherapyinpatientswithcoronaryarterydisease
_version_	1718393888220119040

Impact of bleeding during dual antiplatelet therapy in patients with coronary artery disease

Ejemplares similares