Matrix stiffness controls lymphatic vessel formation through regulation of a GATA2-dependent transcriptional program

Mechanical cues are known to influence endothelial cell behavior. Here Frye et al. show that lymphatic endothelial cell progenitors experience varying degrees of matrix stiffness during development, and that matrix stiffness regulates GATA2 expression to drive lymphatic vessel formation.

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Autores principales:	Maike Frye, Andrea Taddei, Cathrin Dierkes, Ines Martinez-Corral, Matthew Fielden, Henrik Ortsäter, Jan Kazenwadel, Dinis P. Calado, Pia Ostergaard, Marjo Salminen, Liqun He, Natasha L. Harvey, Friedemann Kiefer, Taija Mäkinen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d7157b72d40e47f885661cb7f76b2542
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spelling	oai:doaj.org-article:d7157b72d40e47f885661cb7f76b25422021-12-02T14:40:44ZMatrix stiffness controls lymphatic vessel formation through regulation of a GATA2-dependent transcriptional program10.1038/s41467-018-03959-62041-1723https://doaj.org/article/d7157b72d40e47f885661cb7f76b25422018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03959-6https://doaj.org/toc/2041-1723Mechanical cues are known to influence endothelial cell behavior. Here Frye et al. show that lymphatic endothelial cell progenitors experience varying degrees of matrix stiffness during development, and that matrix stiffness regulates GATA2 expression to drive lymphatic vessel formation.Maike FryeAndrea TaddeiCathrin DierkesInes Martinez-CorralMatthew FieldenHenrik OrtsäterJan KazenwadelDinis P. CaladoPia OstergaardMarjo SalminenLiqun HeNatasha L. HarveyFriedemann KieferTaija MäkinenNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Maike Frye Andrea Taddei Cathrin Dierkes Ines Martinez-Corral Matthew Fielden Henrik Ortsäter Jan Kazenwadel Dinis P. Calado Pia Ostergaard Marjo Salminen Liqun He Natasha L. Harvey Friedemann Kiefer Taija Mäkinen Matrix stiffness controls lymphatic vessel formation through regulation of a GATA2-dependent transcriptional program
description	Mechanical cues are known to influence endothelial cell behavior. Here Frye et al. show that lymphatic endothelial cell progenitors experience varying degrees of matrix stiffness during development, and that matrix stiffness regulates GATA2 expression to drive lymphatic vessel formation.
format	article
author	Maike Frye Andrea Taddei Cathrin Dierkes Ines Martinez-Corral Matthew Fielden Henrik Ortsäter Jan Kazenwadel Dinis P. Calado Pia Ostergaard Marjo Salminen Liqun He Natasha L. Harvey Friedemann Kiefer Taija Mäkinen
author_facet	Maike Frye Andrea Taddei Cathrin Dierkes Ines Martinez-Corral Matthew Fielden Henrik Ortsäter Jan Kazenwadel Dinis P. Calado Pia Ostergaard Marjo Salminen Liqun He Natasha L. Harvey Friedemann Kiefer Taija Mäkinen
author_sort	Maike Frye
title	Matrix stiffness controls lymphatic vessel formation through regulation of a GATA2-dependent transcriptional program
title_short	Matrix stiffness controls lymphatic vessel formation through regulation of a GATA2-dependent transcriptional program
title_full	Matrix stiffness controls lymphatic vessel formation through regulation of a GATA2-dependent transcriptional program
title_fullStr	Matrix stiffness controls lymphatic vessel formation through regulation of a GATA2-dependent transcriptional program
title_full_unstemmed	Matrix stiffness controls lymphatic vessel formation through regulation of a GATA2-dependent transcriptional program
title_sort	matrix stiffness controls lymphatic vessel formation through regulation of a gata2-dependent transcriptional program
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/d7157b72d40e47f885661cb7f76b2542
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Matrix stiffness controls lymphatic vessel formation through regulation of a GATA2-dependent transcriptional program

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