Matrix stiffness controls lymphatic vessel formation through regulation of a GATA2-dependent transcriptional program

Matrix stiffness controls lymphatic vessel formation through regulation of a GATA2-dependent transcriptional program

Mechanical cues are known to influence endothelial cell behavior. Here Frye et al. show that lymphatic endothelial cell progenitors experience varying degrees of matrix stiffness during development, and that matrix stiffness regulates GATA2 expression to drive lymphatic vessel formation.

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Detalles Bibliográficos
Autores principales: Maike Frye, Andrea Taddei, Cathrin Dierkes, Ines Martinez-Corral, Matthew Fielden, Henrik Ortsäter, Jan Kazenwadel, Dinis P. Calado, Pia Ostergaard, Marjo Salminen, Liqun He, Natasha L. Harvey, Friedemann Kiefer, Taija Mäkinen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/d7157b72d40e47f885661cb7f76b2542
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