Lipoic Acid Metabolism as a Potential Chemotherapeutic Target Against Plasmodium falciparum and Staphylococcus aureus

Lipoic acid (LA) is an organic compound that plays a key role in cellular metabolism. It participates in a posttranslational modification (PTM) named lipoylation, an event that is highly conserved and that occurs in multimeric metabolic enzymes of very distinct microorganisms such as Plasmodium sp....

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Sun Liu Rei Yan, Felipe Wakasuqui, Xiaochen Du, Matthew R. Groves, Carsten Wrenger
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	Lipoic acid malaria protein lipoylation Plasmodium S. aureus Lipoic acid (LA) Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/d71666ee879c49b0b107c1a5060cd4a1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d71666ee879c49b0b107c1a5060cd4a1
record_format	dspace
spelling	oai:doaj.org-article:d71666ee879c49b0b107c1a5060cd4a12021-11-04T07:43:21ZLipoic Acid Metabolism as a Potential Chemotherapeutic Target Against Plasmodium falciparum and Staphylococcus aureus2296-264610.3389/fchem.2021.742175https://doaj.org/article/d71666ee879c49b0b107c1a5060cd4a12021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fchem.2021.742175/fullhttps://doaj.org/toc/2296-2646Lipoic acid (LA) is an organic compound that plays a key role in cellular metabolism. It participates in a posttranslational modification (PTM) named lipoylation, an event that is highly conserved and that occurs in multimeric metabolic enzymes of very distinct microorganisms such as Plasmodium sp. and Staphylococcus aureus, including pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase (KDH). In this mini review, we revisit the recent literature regarding LA metabolism in Plasmodium sp. and Staphylococcus aureus, by covering the lipoate ligase proteins in both microorganisms, the role of lipoate ligase proteins and insights for possible inhibitors of lipoate ligases.Sun Liu Rei YanFelipe WakasuquiXiaochen DuMatthew R. GrovesCarsten WrengerFrontiers Media S.A.articleLipoic acidmalariaprotein lipoylationPlasmodiumS. aureusLipoic acid (LA)ChemistryQD1-999ENFrontiers in Chemistry, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Lipoic acid malaria protein lipoylation Plasmodium S. aureus Lipoic acid (LA) Chemistry QD1-999
spellingShingle	Lipoic acid malaria protein lipoylation Plasmodium S. aureus Lipoic acid (LA) Chemistry QD1-999 Sun Liu Rei Yan Felipe Wakasuqui Xiaochen Du Matthew R. Groves Carsten Wrenger Lipoic Acid Metabolism as a Potential Chemotherapeutic Target Against Plasmodium falciparum and Staphylococcus aureus
description	Lipoic acid (LA) is an organic compound that plays a key role in cellular metabolism. It participates in a posttranslational modification (PTM) named lipoylation, an event that is highly conserved and that occurs in multimeric metabolic enzymes of very distinct microorganisms such as Plasmodium sp. and Staphylococcus aureus, including pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase (KDH). In this mini review, we revisit the recent literature regarding LA metabolism in Plasmodium sp. and Staphylococcus aureus, by covering the lipoate ligase proteins in both microorganisms, the role of lipoate ligase proteins and insights for possible inhibitors of lipoate ligases.
format	article
author	Sun Liu Rei Yan Felipe Wakasuqui Xiaochen Du Matthew R. Groves Carsten Wrenger
author_facet	Sun Liu Rei Yan Felipe Wakasuqui Xiaochen Du Matthew R. Groves Carsten Wrenger
author_sort	Sun Liu Rei Yan
title	Lipoic Acid Metabolism as a Potential Chemotherapeutic Target Against Plasmodium falciparum and Staphylococcus aureus
title_short	Lipoic Acid Metabolism as a Potential Chemotherapeutic Target Against Plasmodium falciparum and Staphylococcus aureus
title_full	Lipoic Acid Metabolism as a Potential Chemotherapeutic Target Against Plasmodium falciparum and Staphylococcus aureus
title_fullStr	Lipoic Acid Metabolism as a Potential Chemotherapeutic Target Against Plasmodium falciparum and Staphylococcus aureus
title_full_unstemmed	Lipoic Acid Metabolism as a Potential Chemotherapeutic Target Against Plasmodium falciparum and Staphylococcus aureus
title_sort	lipoic acid metabolism as a potential chemotherapeutic target against plasmodium falciparum and staphylococcus aureus
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/d71666ee879c49b0b107c1a5060cd4a1
work_keys_str_mv	AT sunliureiyan lipoicacidmetabolismasapotentialchemotherapeutictargetagainstplasmodiumfalciparumandstaphylococcusaureus AT felipewakasuqui lipoicacidmetabolismasapotentialchemotherapeutictargetagainstplasmodiumfalciparumandstaphylococcusaureus AT xiaochendu lipoicacidmetabolismasapotentialchemotherapeutictargetagainstplasmodiumfalciparumandstaphylococcusaureus AT matthewrgroves lipoicacidmetabolismasapotentialchemotherapeutictargetagainstplasmodiumfalciparumandstaphylococcusaureus AT carstenwrenger lipoicacidmetabolismasapotentialchemotherapeutictargetagainstplasmodiumfalciparumandstaphylococcusaureus
_version_	1718445051699265536

Lipoic Acid Metabolism as a Potential Chemotherapeutic Target Against Plasmodium falciparum and Staphylococcus aureus

Ejemplares similares