Heparin and Derivatives for Advanced Cell Therapies

Heparin and its derivatives are saving thousands of human lives annually, by successfully preventing and treating thromboembolic events. Although the mode of action during anticoagulation is well studied, their influence on cell behavior is not fully understood as is the risk of bleeding and other s...

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Autores principales:	Sandra Laner-Plamberger, Michaela Oeller, Eva Rohde, Katharina Schallmoser, Dirk Strunk
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	heparin cell therapy regenerative medicine biomaterials human platelet lysate extracellular vesicles Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/d718155f4c184c03b98c809c399e11cb
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id	oai:doaj.org-article:d718155f4c184c03b98c809c399e11cb
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spelling	oai:doaj.org-article:d718155f4c184c03b98c809c399e11cb2021-11-11T17:26:24ZHeparin and Derivatives for Advanced Cell Therapies10.3390/ijms2221120411422-00671661-6596https://doaj.org/article/d718155f4c184c03b98c809c399e11cb2021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/12041https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Heparin and its derivatives are saving thousands of human lives annually, by successfully preventing and treating thromboembolic events. Although the mode of action during anticoagulation is well studied, their influence on cell behavior is not fully understood as is the risk of bleeding and other side effects. New applications in regenerative medicine have evolved supporting production of cell-based therapeutics or as a substrate for creating functionalized matrices in biotechnology. The currently resurgent interest in heparins is related to the expected combined anti-inflammatory, anti-thrombotic and anti-viral action against COVID-19. Based on a concise summary of key biochemical and clinical data, this review summarizes the impact for manufacturing and application of cell therapeutics and highlights the need for discriminating the different heparins.Sandra Laner-PlambergerMichaela OellerEva RohdeKatharina SchallmoserDirk StrunkMDPI AGarticleheparincell therapyregenerative medicinebiomaterialshuman platelet lysateextracellular vesiclesBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12041, p 12041 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	heparin cell therapy regenerative medicine biomaterials human platelet lysate extracellular vesicles Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	heparin cell therapy regenerative medicine biomaterials human platelet lysate extracellular vesicles Biology (General) QH301-705.5 Chemistry QD1-999 Sandra Laner-Plamberger Michaela Oeller Eva Rohde Katharina Schallmoser Dirk Strunk Heparin and Derivatives for Advanced Cell Therapies
description	Heparin and its derivatives are saving thousands of human lives annually, by successfully preventing and treating thromboembolic events. Although the mode of action during anticoagulation is well studied, their influence on cell behavior is not fully understood as is the risk of bleeding and other side effects. New applications in regenerative medicine have evolved supporting production of cell-based therapeutics or as a substrate for creating functionalized matrices in biotechnology. The currently resurgent interest in heparins is related to the expected combined anti-inflammatory, anti-thrombotic and anti-viral action against COVID-19. Based on a concise summary of key biochemical and clinical data, this review summarizes the impact for manufacturing and application of cell therapeutics and highlights the need for discriminating the different heparins.
format	article
author	Sandra Laner-Plamberger Michaela Oeller Eva Rohde Katharina Schallmoser Dirk Strunk
author_facet	Sandra Laner-Plamberger Michaela Oeller Eva Rohde Katharina Schallmoser Dirk Strunk
author_sort	Sandra Laner-Plamberger
title	Heparin and Derivatives for Advanced Cell Therapies
title_short	Heparin and Derivatives for Advanced Cell Therapies
title_full	Heparin and Derivatives for Advanced Cell Therapies
title_fullStr	Heparin and Derivatives for Advanced Cell Therapies
title_full_unstemmed	Heparin and Derivatives for Advanced Cell Therapies
title_sort	heparin and derivatives for advanced cell therapies
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/d718155f4c184c03b98c809c399e11cb
work_keys_str_mv	AT sandralanerplamberger heparinandderivativesforadvancedcelltherapies AT michaelaoeller heparinandderivativesforadvancedcelltherapies AT evarohde heparinandderivativesforadvancedcelltherapies AT katharinaschallmoser heparinandderivativesforadvancedcelltherapies AT dirkstrunk heparinandderivativesforadvancedcelltherapies
_version_	1718432090903543808

Heparin and Derivatives for Advanced Cell Therapies

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