A genome-scale map of DNA methylation turnover identifies site-specific dependencies of DNMT and TET activity

A genome-scale map of DNA methylation turnover identifies site-specific dependencies of DNMT and TET activity

Local activity of the DNA methylation machinery remains poorly understood. Here, the authors present a theoretical and experimental framework to infer methylation and demethylation rates at genome scale in mouse embryonic stem cells, finding that maintenance methylation activity is reduced at transc...

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Autores principales: Paul Adrian Ginno, Dimos Gaidatzis, Angelika Feldmann, Leslie Hoerner, Dilek Imanci, Lukas Burger, Frederic Zilbermann, Antoine H. F. M. Peters, Frank Edenhofer, Sébastien A. Smallwood, Arnaud R. Krebs, Dirk Schübeler
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
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Acceso en línea:https://doaj.org/article/d71bbc029bb84f98b2659275c30cb32d
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