CD8+ tissue-resident memory T cells promote liver fibrosis resolution by inducing apoptosis of hepatic stellate cells

The cellular and molecular mechanisms underlying the resolution of non-alcoholic steatohepatitis remain incompletely understood. Here the authors report a single cell-based analysis that identified CD8 + tissue-resident memory T cells, which contribute to resolution of liver fibrosis potentially via...

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Autores principales:	Yuzo Koda, Toshiaki Teratani, Po-Sung Chu, Yuya Hagihara, Yohei Mikami, Yosuke Harada, Hanako Tsujikawa, Kentaro Miyamoto, Takahiro Suzuki, Nobuhito Taniki, Tomohisa Sujino, Michiie Sakamoto, Takanori Kanai, Nobuhiro Nakamoto
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d71c0f9847254bb399f23ec2f314021b
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spelling	oai:doaj.org-article:d71c0f9847254bb399f23ec2f314021b2021-12-02T16:18:00ZCD8+ tissue-resident memory T cells promote liver fibrosis resolution by inducing apoptosis of hepatic stellate cells10.1038/s41467-021-24734-02041-1723https://doaj.org/article/d71c0f9847254bb399f23ec2f314021b2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24734-0https://doaj.org/toc/2041-1723The cellular and molecular mechanisms underlying the resolution of non-alcoholic steatohepatitis remain incompletely understood. Here the authors report a single cell-based analysis that identified CD8 + tissue-resident memory T cells, which contribute to resolution of liver fibrosis potentially via elimination of hepatic stellate cells through Fas-mediated cytotoxicity.Yuzo KodaToshiaki TerataniPo-Sung ChuYuya HagiharaYohei MikamiYosuke HaradaHanako TsujikawaKentaro MiyamotoTakahiro SuzukiNobuhito TanikiTomohisa SujinoMichiie SakamotoTakanori KanaiNobuhiro NakamotoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yuzo Koda Toshiaki Teratani Po-Sung Chu Yuya Hagihara Yohei Mikami Yosuke Harada Hanako Tsujikawa Kentaro Miyamoto Takahiro Suzuki Nobuhito Taniki Tomohisa Sujino Michiie Sakamoto Takanori Kanai Nobuhiro Nakamoto CD8+ tissue-resident memory T cells promote liver fibrosis resolution by inducing apoptosis of hepatic stellate cells
description	The cellular and molecular mechanisms underlying the resolution of non-alcoholic steatohepatitis remain incompletely understood. Here the authors report a single cell-based analysis that identified CD8 + tissue-resident memory T cells, which contribute to resolution of liver fibrosis potentially via elimination of hepatic stellate cells through Fas-mediated cytotoxicity.
format	article
author	Yuzo Koda Toshiaki Teratani Po-Sung Chu Yuya Hagihara Yohei Mikami Yosuke Harada Hanako Tsujikawa Kentaro Miyamoto Takahiro Suzuki Nobuhito Taniki Tomohisa Sujino Michiie Sakamoto Takanori Kanai Nobuhiro Nakamoto
author_facet	Yuzo Koda Toshiaki Teratani Po-Sung Chu Yuya Hagihara Yohei Mikami Yosuke Harada Hanako Tsujikawa Kentaro Miyamoto Takahiro Suzuki Nobuhito Taniki Tomohisa Sujino Michiie Sakamoto Takanori Kanai Nobuhiro Nakamoto
author_sort	Yuzo Koda
title	CD8+ tissue-resident memory T cells promote liver fibrosis resolution by inducing apoptosis of hepatic stellate cells
title_short	CD8+ tissue-resident memory T cells promote liver fibrosis resolution by inducing apoptosis of hepatic stellate cells
title_full	CD8+ tissue-resident memory T cells promote liver fibrosis resolution by inducing apoptosis of hepatic stellate cells
title_fullStr	CD8+ tissue-resident memory T cells promote liver fibrosis resolution by inducing apoptosis of hepatic stellate cells
title_full_unstemmed	CD8+ tissue-resident memory T cells promote liver fibrosis resolution by inducing apoptosis of hepatic stellate cells
title_sort	cd8+ tissue-resident memory t cells promote liver fibrosis resolution by inducing apoptosis of hepatic stellate cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d71c0f9847254bb399f23ec2f314021b
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CD8+ tissue-resident memory T cells promote liver fibrosis resolution by inducing apoptosis of hepatic stellate cells

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