β-arrestin-2 regulates NMDA receptor function in spinal lamina II neurons and duration of persistent pain

β-arrestin-2 regulates NMDA receptor function in spinal lamina II neurons and duration of persistent pain

The cellular mechanisms underlying acute pain transitions to chronic pain are poorly understood. Here the authors show that the scaffolding protein β-arrestin 2 contributes to these processes via desensitization of NMDA receptors in spinal neurons.

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Autores principales: Gang Chen, Rou-Gang Xie, Yong-Jing Gao, Zhen-Zhong Xu, Lin-Xia Zhao, Sangsu Bang, Temugin Berta, Chul-Kyu Park, Mark Lay, Wei Chen, Ru-Rong Ji
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Q
Acceso en línea:https://doaj.org/article/d71d3fc96fe3477b80fc968a12f53cb5
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spelling oai:doaj.org-article:d71d3fc96fe3477b80fc968a12f53cb52021-12-02T14:39:54Zβ-arrestin-2 regulates NMDA receptor function in spinal lamina II neurons and duration of persistent pain10.1038/ncomms125312041-1723https://doaj.org/article/d71d3fc96fe3477b80fc968a12f53cb52016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12531https://doaj.org/toc/2041-1723The cellular mechanisms underlying acute pain transitions to chronic pain are poorly understood. Here the authors show that the scaffolding protein β-arrestin 2 contributes to these processes via desensitization of NMDA receptors in spinal neurons.Gang ChenRou-Gang XieYong-Jing GaoZhen-Zhong XuLin-Xia ZhaoSangsu BangTemugin BertaChul-Kyu ParkMark LayWei ChenRu-Rong JiNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Gang Chen
Rou-Gang Xie
Yong-Jing Gao
Zhen-Zhong Xu
Lin-Xia Zhao
Sangsu Bang
Temugin Berta
Chul-Kyu Park
Mark Lay
Wei Chen
Ru-Rong Ji
β-arrestin-2 regulates NMDA receptor function in spinal lamina II neurons and duration of persistent pain
description The cellular mechanisms underlying acute pain transitions to chronic pain are poorly understood. Here the authors show that the scaffolding protein β-arrestin 2 contributes to these processes via desensitization of NMDA receptors in spinal neurons.
format article
author Gang Chen
Rou-Gang Xie
Yong-Jing Gao
Zhen-Zhong Xu
Lin-Xia Zhao
Sangsu Bang
Temugin Berta
Chul-Kyu Park
Mark Lay
Wei Chen
Ru-Rong Ji
author_facet Gang Chen
Rou-Gang Xie
Yong-Jing Gao
Zhen-Zhong Xu
Lin-Xia Zhao
Sangsu Bang
Temugin Berta
Chul-Kyu Park
Mark Lay
Wei Chen
Ru-Rong Ji
author_sort Gang Chen
title β-arrestin-2 regulates NMDA receptor function in spinal lamina II neurons and duration of persistent pain
title_short β-arrestin-2 regulates NMDA receptor function in spinal lamina II neurons and duration of persistent pain
title_full β-arrestin-2 regulates NMDA receptor function in spinal lamina II neurons and duration of persistent pain
title_fullStr β-arrestin-2 regulates NMDA receptor function in spinal lamina II neurons and duration of persistent pain
title_full_unstemmed β-arrestin-2 regulates NMDA receptor function in spinal lamina II neurons and duration of persistent pain
title_sort β-arrestin-2 regulates nmda receptor function in spinal lamina ii neurons and duration of persistent pain
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/d71d3fc96fe3477b80fc968a12f53cb5
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