β-arrestin-2 regulates NMDA receptor function in spinal lamina II neurons and duration of persistent pain

β-arrestin-2 regulates NMDA receptor function in spinal lamina II neurons and duration of persistent pain

The cellular mechanisms underlying acute pain transitions to chronic pain are poorly understood. Here the authors show that the scaffolding protein β-arrestin 2 contributes to these processes via desensitization of NMDA receptors in spinal neurons.

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Autores principales: Gang Chen, Rou-Gang Xie, Yong-Jing Gao, Zhen-Zhong Xu, Lin-Xia Zhao, Sangsu Bang, Temugin Berta, Chul-Kyu Park, Mark Lay, Wei Chen, Ru-Rong Ji
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
Materias:
Science
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Acceso en línea:https://doaj.org/article/d71d3fc96fe3477b80fc968a12f53cb5
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