Origin and age of the causative mutations in KLC2, IMPA1, MED25 and WNT7A unravelled through Brazilian admixed populations

Abstract The mutation age and local ancestry of chromosomal segments harbouring mutations associated with autosomal recessive (AR) disorders in Brazilian admixed populations remain unknown; additionally, inbreeding levels for these affected individuals continue to be estimated based on genealogical...

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Autores principales:	Allysson Allan de Farias, Kelly Nunes, Renan Barbosa Lemes, Ronald Moura, Gustavo Ribeiro Fernandes, Uirá Souto Melo, Mayana Zatz, Fernando Kok, Silvana Santos
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Autosomal Recessive (AR) Most Recent Common Ancestor (MRCA) Local Ancestry Inference (LAI) Locus-specific Ancestry Global Ancestry Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d723e7e4b3614cfe81131cb8fa90adec
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Origin and age of the causative mutations in KLC2, IMPA1, MED25 and WNT7A unravelled through Brazilian admixed populations

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