Higher Triglyceride–Glucose Index Is Associated With Increased Likelihood of Kidney Stones
AimsWe aimed to assess the association between triglyceride–glucose (TyG) index and kidney stones in US adults.MethodsData were obtained from the 2007–2014 National Health and Nutrition Examination Survey (NHANES). Participants aged ≥18 years who were not pregnant and provided complete data about Ty...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:d7282c868b2d433395d2b07e3d4ac11b2021-12-01T13:27:29ZHigher Triglyceride–Glucose Index Is Associated With Increased Likelihood of Kidney Stones1664-239210.3389/fendo.2021.774567https://doaj.org/article/d7282c868b2d433395d2b07e3d4ac11b2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fendo.2021.774567/fullhttps://doaj.org/toc/1664-2392AimsWe aimed to assess the association between triglyceride–glucose (TyG) index and kidney stones in US adults.MethodsData were obtained from the 2007–2014 National Health and Nutrition Examination Survey (NHANES). Participants aged ≥18 years who were not pregnant and provided complete data about TyG index and kidney stones were included in the analysis. Weighted multivariable regression analysis and subgroup analysis were preformed to estimate the independent relationship between TyG index and nephrolithiasis and recurrence.ResultsA total of 20,972 participants were included with the mean TyG index of 8.71 ± 0.72. The prevalence rates of nephrolithiasis and recurrence were 9.30% and 3.17% overall and increased with the higher TyG index tertiles (Nephrolithiasis: Tertile 1, 6.98%; Tertile 2, 9.15%; Tertile 3, 11.98%, p < 0.01; Recurrence: Tertile 1, 1.84%; Tertile 2, 3.27%; Tertile 3, 4.50%, p < 0.01). Each unit increase in TyG index was associated with 12% and 26% higher odds of nephrolithiasis [odds ratio (OR) = 1.12; 95% CI: 1.02–1.22; p = 0.02] and recurrence (OR = 1.26; 95% CI: 1.08–1.46; p < 0.01). Interaction tests indicated no significant effect of gender, age, body mass index, hypertension, and diabetes on this association between TyG index and kidney stones.ConclusionsHigher TyG index was associated with an increased likelihood of nephrolithiasis and recurrence. Considering TyG index is a reliable indicator of insulin resistance (IR). Treatment and management of IR at a younger age may improve or alleviate the occurrence and recurrence of kidney stones.Zheng QinZheng QinZheng QinJunjie ZhaoJiwen GengJiwen GengJiwen GengKaixi ChangKaixi ChangKaixi ChangRuoxi LiaoRuoxi LiaoRuoxi LiaoBaihai SuBaihai SuBaihai SuFrontiers Media S.A.articleinsulin resistancetriglyceride–glucose indexkidney stonesNHANEScross-sectional studyDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENFrontiers in Endocrinology, Vol 12 (2021) |
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DOAJ |
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EN |
| topic |
insulin resistance triglyceride–glucose index kidney stones NHANES cross-sectional study Diseases of the endocrine glands. Clinical endocrinology RC648-665 |
| spellingShingle |
insulin resistance triglyceride–glucose index kidney stones NHANES cross-sectional study Diseases of the endocrine glands. Clinical endocrinology RC648-665 Zheng Qin Zheng Qin Zheng Qin Junjie Zhao Jiwen Geng Jiwen Geng Jiwen Geng Kaixi Chang Kaixi Chang Kaixi Chang Ruoxi Liao Ruoxi Liao Ruoxi Liao Baihai Su Baihai Su Baihai Su Higher Triglyceride–Glucose Index Is Associated With Increased Likelihood of Kidney Stones |
| description |
AimsWe aimed to assess the association between triglyceride–glucose (TyG) index and kidney stones in US adults.MethodsData were obtained from the 2007–2014 National Health and Nutrition Examination Survey (NHANES). Participants aged ≥18 years who were not pregnant and provided complete data about TyG index and kidney stones were included in the analysis. Weighted multivariable regression analysis and subgroup analysis were preformed to estimate the independent relationship between TyG index and nephrolithiasis and recurrence.ResultsA total of 20,972 participants were included with the mean TyG index of 8.71 ± 0.72. The prevalence rates of nephrolithiasis and recurrence were 9.30% and 3.17% overall and increased with the higher TyG index tertiles (Nephrolithiasis: Tertile 1, 6.98%; Tertile 2, 9.15%; Tertile 3, 11.98%, p < 0.01; Recurrence: Tertile 1, 1.84%; Tertile 2, 3.27%; Tertile 3, 4.50%, p < 0.01). Each unit increase in TyG index was associated with 12% and 26% higher odds of nephrolithiasis [odds ratio (OR) = 1.12; 95% CI: 1.02–1.22; p = 0.02] and recurrence (OR = 1.26; 95% CI: 1.08–1.46; p < 0.01). Interaction tests indicated no significant effect of gender, age, body mass index, hypertension, and diabetes on this association between TyG index and kidney stones.ConclusionsHigher TyG index was associated with an increased likelihood of nephrolithiasis and recurrence. Considering TyG index is a reliable indicator of insulin resistance (IR). Treatment and management of IR at a younger age may improve or alleviate the occurrence and recurrence of kidney stones. |
| format |
article |
| author |
Zheng Qin Zheng Qin Zheng Qin Junjie Zhao Jiwen Geng Jiwen Geng Jiwen Geng Kaixi Chang Kaixi Chang Kaixi Chang Ruoxi Liao Ruoxi Liao Ruoxi Liao Baihai Su Baihai Su Baihai Su |
| author_facet |
Zheng Qin Zheng Qin Zheng Qin Junjie Zhao Jiwen Geng Jiwen Geng Jiwen Geng Kaixi Chang Kaixi Chang Kaixi Chang Ruoxi Liao Ruoxi Liao Ruoxi Liao Baihai Su Baihai Su Baihai Su |
| author_sort |
Zheng Qin |
| title |
Higher Triglyceride–Glucose Index Is Associated With Increased Likelihood of Kidney Stones |
| title_short |
Higher Triglyceride–Glucose Index Is Associated With Increased Likelihood of Kidney Stones |
| title_full |
Higher Triglyceride–Glucose Index Is Associated With Increased Likelihood of Kidney Stones |
| title_fullStr |
Higher Triglyceride–Glucose Index Is Associated With Increased Likelihood of Kidney Stones |
| title_full_unstemmed |
Higher Triglyceride–Glucose Index Is Associated With Increased Likelihood of Kidney Stones |
| title_sort |
higher triglyceride–glucose index is associated with increased likelihood of kidney stones |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/d7282c868b2d433395d2b07e3d4ac11b |
| work_keys_str_mv |
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