Questioning the causal link between maternal smoking during pregnancy and offspring use of psychotropic medication: a sibling design analysis.

A recent population-based, longitudinal study from Finland observed a dose-response association between smoking during pregnancy (SDP) and use of psychotropic medications in exposed children and young adults. However, this association may be confounded by unmeasured familial characteristics related...

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Autores principales:	Lovisa Söderström, Raquel Perez-Vicente, Sol Juárez, Juan Merlo
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d72a763dd4144a9c95aff80fdf0a5945
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spelling	oai:doaj.org-article:d72a763dd4144a9c95aff80fdf0a59452021-11-18T07:46:19ZQuestioning the causal link between maternal smoking during pregnancy and offspring use of psychotropic medication: a sibling design analysis.1932-620310.1371/journal.pone.0063420https://doaj.org/article/d72a763dd4144a9c95aff80fdf0a59452013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23667614/?tool=EBIhttps://doaj.org/toc/1932-6203A recent population-based, longitudinal study from Finland observed a dose-response association between smoking during pregnancy (SDP) and use of psychotropic medications in exposed children and young adults. However, this association may be confounded by unmeasured familial characteristics related to both SDP and offspring mental health. Consequently, we aim to investigate the effect of SDP by means of a sibling design that to some extent allows controlling for unknown environmental and genetic confounders. Using the Swedish Medical Birth Register (1987-1993), which was linked to the Swedish Prescribed Drugs Register (July 2005-December 2008), we investigated 579,543 children and among them 39, 007 were discordant for use of psychotropic medication and 4,021 siblings discordant for both use of psychotropic medication and for smoking exposure. Replicating the Finnish study using traditional logistic regression methods we found an association between exposure to ≥10 cigarettes per day during pregnancy and psychotropic drug use (odds ratio = 1.61, 95% confidence interval 1.56, 1.66). Similar in size to the association reported from Finland (odds ratio = 1.63; 95% confidence interval 1.53, 1.74). However, in the adjusted sibling analysis using conditional logistic regression, the association was considerably reduced (odds ratio 1.22; 95% confidence interval 1.08, 1.38). Preventing smoking is of major public health importance. However, SDP per se appears to have less influence on offspring psychotropic drug use than previously suggested.Lovisa SöderströmRaquel Perez-VicenteSol JuárezJuan MerloPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 5, p e63420 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lovisa Söderström Raquel Perez-Vicente Sol Juárez Juan Merlo Questioning the causal link between maternal smoking during pregnancy and offspring use of psychotropic medication: a sibling design analysis.
description	A recent population-based, longitudinal study from Finland observed a dose-response association between smoking during pregnancy (SDP) and use of psychotropic medications in exposed children and young adults. However, this association may be confounded by unmeasured familial characteristics related to both SDP and offspring mental health. Consequently, we aim to investigate the effect of SDP by means of a sibling design that to some extent allows controlling for unknown environmental and genetic confounders. Using the Swedish Medical Birth Register (1987-1993), which was linked to the Swedish Prescribed Drugs Register (July 2005-December 2008), we investigated 579,543 children and among them 39, 007 were discordant for use of psychotropic medication and 4,021 siblings discordant for both use of psychotropic medication and for smoking exposure. Replicating the Finnish study using traditional logistic regression methods we found an association between exposure to ≥10 cigarettes per day during pregnancy and psychotropic drug use (odds ratio = 1.61, 95% confidence interval 1.56, 1.66). Similar in size to the association reported from Finland (odds ratio = 1.63; 95% confidence interval 1.53, 1.74). However, in the adjusted sibling analysis using conditional logistic regression, the association was considerably reduced (odds ratio 1.22; 95% confidence interval 1.08, 1.38). Preventing smoking is of major public health importance. However, SDP per se appears to have less influence on offspring psychotropic drug use than previously suggested.
format	article
author	Lovisa Söderström Raquel Perez-Vicente Sol Juárez Juan Merlo
author_facet	Lovisa Söderström Raquel Perez-Vicente Sol Juárez Juan Merlo
author_sort	Lovisa Söderström
title	Questioning the causal link between maternal smoking during pregnancy and offspring use of psychotropic medication: a sibling design analysis.
title_short	Questioning the causal link between maternal smoking during pregnancy and offspring use of psychotropic medication: a sibling design analysis.
title_full	Questioning the causal link between maternal smoking during pregnancy and offspring use of psychotropic medication: a sibling design analysis.
title_fullStr	Questioning the causal link between maternal smoking during pregnancy and offspring use of psychotropic medication: a sibling design analysis.
title_full_unstemmed	Questioning the causal link between maternal smoking during pregnancy and offspring use of psychotropic medication: a sibling design analysis.
title_sort	questioning the causal link between maternal smoking during pregnancy and offspring use of psychotropic medication: a sibling design analysis.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/d72a763dd4144a9c95aff80fdf0a5945
work_keys_str_mv	AT lovisasoderstrom questioningthecausallinkbetweenmaternalsmokingduringpregnancyandoffspringuseofpsychotropicmedicationasiblingdesignanalysis AT raquelperezvicente questioningthecausallinkbetweenmaternalsmokingduringpregnancyandoffspringuseofpsychotropicmedicationasiblingdesignanalysis AT soljuarez questioningthecausallinkbetweenmaternalsmokingduringpregnancyandoffspringuseofpsychotropicmedicationasiblingdesignanalysis AT juanmerlo questioningthecausallinkbetweenmaternalsmokingduringpregnancyandoffspringuseofpsychotropicmedicationasiblingdesignanalysis
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Questioning the causal link between maternal smoking during pregnancy and offspring use of psychotropic medication: a sibling design analysis.

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