Berberine-loaded Janus gold mesoporous silica nanocarriers for chemo/radio/photothermal therapy of liver cancer and radiation-induced injury inhibition

Xiao-Dong Li,1–3 Zheng Wang,1,2 Xin-Rui Wang,4 Dan Shao,1 Xi Zhang,5 Li Li,1 Ming-Feng Ge,1 Zhi-Min Chang,1 Wen-Fei Dong11CAS Key Laboratory of Bio-Medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, People’s...

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Autores principales:	Li XD, Wang Z, Wang XR, Shao D, Zhang X, Li L, Ge MF, Chang ZM, Dong WF
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Berberine chemotherapy radio-sensitization Au MSNs Janus photothermal therapy Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/d72b9c2b43294e75839d6fc690adb297
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spelling	oai:doaj.org-article:d72b9c2b43294e75839d6fc690adb2972021-12-02T07:32:59ZBerberine-loaded Janus gold mesoporous silica nanocarriers for chemo/radio/photothermal therapy of liver cancer and radiation-induced injury inhibition1178-2013https://doaj.org/article/d72b9c2b43294e75839d6fc690adb2972019-05-01T00:00:00Zhttps://www.dovepress.com/berberine-loaded-janus-gold-mesoporous-silica-nanocarriers-for-chemora-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Xiao-Dong Li,1–3 Zheng Wang,1,2 Xin-Rui Wang,4 Dan Shao,1 Xi Zhang,5 Li Li,1 Ming-Feng Ge,1 Zhi-Min Chang,1 Wen-Fei Dong11CAS Key Laboratory of Bio-Medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, People’s Republic of China; 2University of Chinese Academy of Sciences, Beijing 100049, People’s Republic of China; 3Department of Echocardiography, The First Hospital of Jilin University, Changchun 130021, People’s Republic of China; 4Department of Hepatology, The First Hospital of Jilin University, Changchun 130021, People’s Republic of China; 5Department of Rheumatology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, People’s Republic of ChinaBackground: The combination of chemotherapy with radiotherapy serves as a common therapeutic strategy in clinics. However, it is unsatisfactory due to its poor therapeutic efficiency and severe side-effects originating from chemotherapy-exerted systemic toxicity as well as radiation-induced injury.Purpose: Hence, Berberine (Ber), an isoquinolin alkaloid with low toxicity and protective effects against radiotherapy, was used as a novel chemotherapeutic agent for chemo-radiotherapy of liver cancer.Patients and methods: We preloaded Ber into folic acid targeting Janus gold mesoporous silica nanocarriers (FA-JGMSNs) for overcoming the poor bioavailability of Ber. Furthermore, FA-JGMSNs were not only employed as radiosensitizers for expanding radiotherapeutic effect, but also used as photothermal agents for supplementing chemo-radiotherapeutic effect by local photothermal therapy.Results: In vitro and in vivo experiemtal results demonstrated the highly efficient anti-tumor effect, good biosafety as well as the effective protection of normal tissue of this nanoplatform.Conclusion: Based on its superb performance, we believe our work provided a feasible strategy for triple-therapies of liver cancer.Keywords: Berberine, chemotherapy, radio-sensitization, Au MSNs, Janus, photothermal therapyLi XDWang ZWang XRShao DZhang XLi LGe MFChang ZMDong WFDove Medical PressarticleBerberinechemotherapyradio-sensitizationAu MSNsJanusphotothermal therapyMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 3967-3982 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Berberine chemotherapy radio-sensitization Au MSNs Janus photothermal therapy Medicine (General) R5-920
spellingShingle	Berberine chemotherapy radio-sensitization Au MSNs Janus photothermal therapy Medicine (General) R5-920 Li XD Wang Z Wang XR Shao D Zhang X Li L Ge MF Chang ZM Dong WF Berberine-loaded Janus gold mesoporous silica nanocarriers for chemo/radio/photothermal therapy of liver cancer and radiation-induced injury inhibition
description	Xiao-Dong Li,1–3 Zheng Wang,1,2 Xin-Rui Wang,4 Dan Shao,1 Xi Zhang,5 Li Li,1 Ming-Feng Ge,1 Zhi-Min Chang,1 Wen-Fei Dong11CAS Key Laboratory of Bio-Medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, People’s Republic of China; 2University of Chinese Academy of Sciences, Beijing 100049, People’s Republic of China; 3Department of Echocardiography, The First Hospital of Jilin University, Changchun 130021, People’s Republic of China; 4Department of Hepatology, The First Hospital of Jilin University, Changchun 130021, People’s Republic of China; 5Department of Rheumatology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, People’s Republic of ChinaBackground: The combination of chemotherapy with radiotherapy serves as a common therapeutic strategy in clinics. However, it is unsatisfactory due to its poor therapeutic efficiency and severe side-effects originating from chemotherapy-exerted systemic toxicity as well as radiation-induced injury.Purpose: Hence, Berberine (Ber), an isoquinolin alkaloid with low toxicity and protective effects against radiotherapy, was used as a novel chemotherapeutic agent for chemo-radiotherapy of liver cancer.Patients and methods: We preloaded Ber into folic acid targeting Janus gold mesoporous silica nanocarriers (FA-JGMSNs) for overcoming the poor bioavailability of Ber. Furthermore, FA-JGMSNs were not only employed as radiosensitizers for expanding radiotherapeutic effect, but also used as photothermal agents for supplementing chemo-radiotherapeutic effect by local photothermal therapy.Results: In vitro and in vivo experiemtal results demonstrated the highly efficient anti-tumor effect, good biosafety as well as the effective protection of normal tissue of this nanoplatform.Conclusion: Based on its superb performance, we believe our work provided a feasible strategy for triple-therapies of liver cancer.Keywords: Berberine, chemotherapy, radio-sensitization, Au MSNs, Janus, photothermal therapy
format	article
author	Li XD Wang Z Wang XR Shao D Zhang X Li L Ge MF Chang ZM Dong WF
author_facet	Li XD Wang Z Wang XR Shao D Zhang X Li L Ge MF Chang ZM Dong WF
author_sort	Li XD
title	Berberine-loaded Janus gold mesoporous silica nanocarriers for chemo/radio/photothermal therapy of liver cancer and radiation-induced injury inhibition
title_short	Berberine-loaded Janus gold mesoporous silica nanocarriers for chemo/radio/photothermal therapy of liver cancer and radiation-induced injury inhibition
title_full	Berberine-loaded Janus gold mesoporous silica nanocarriers for chemo/radio/photothermal therapy of liver cancer and radiation-induced injury inhibition
title_fullStr	Berberine-loaded Janus gold mesoporous silica nanocarriers for chemo/radio/photothermal therapy of liver cancer and radiation-induced injury inhibition
title_full_unstemmed	Berberine-loaded Janus gold mesoporous silica nanocarriers for chemo/radio/photothermal therapy of liver cancer and radiation-induced injury inhibition
title_sort	berberine-loaded janus gold mesoporous silica nanocarriers for chemo/radio/photothermal therapy of liver cancer and radiation-induced injury inhibition
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/d72b9c2b43294e75839d6fc690adb297
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Berberine-loaded Janus gold mesoporous silica nanocarriers for chemo/radio/photothermal therapy of liver cancer and radiation-induced injury inhibition

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