Membrane type 1 matrix metalloproteinase promotes LDL receptor shedding and accelerates the development of atherosclerosis

Elevated plasma LDL cholesterol levels increase the risk of atherosclerotic cardiovascular disease. Here, the authors show that inhibition of MT1-MMP reduces plasma LDL cholesterol levels and the risk of atherosclerosis, indicating the potential of MT1-MMP inhibition as a lipid-lowering therapy.

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Detalles Bibliográficos
Autores principales:	Adekunle Alabi, Xiao-Dan Xia, Hong-Mei Gu, Faqi Wang, Shi-Jun Deng, Nana Yang, Ayinuer Adijiang, Donna N. Douglas, Norman M. Kneteman, Yazhuo Xue, Li Chen, Shucun Qin, Guiqing Wang, Da-Wei Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d72c4682bad4414eafe52c4f12f492db
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:d72c4682bad4414eafe52c4f12f492db2021-12-02T17:04:30ZMembrane type 1 matrix metalloproteinase promotes LDL receptor shedding and accelerates the development of atherosclerosis10.1038/s41467-021-22167-32041-1723https://doaj.org/article/d72c4682bad4414eafe52c4f12f492db2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22167-3https://doaj.org/toc/2041-1723Elevated plasma LDL cholesterol levels increase the risk of atherosclerotic cardiovascular disease. Here, the authors show that inhibition of MT1-MMP reduces plasma LDL cholesterol levels and the risk of atherosclerosis, indicating the potential of MT1-MMP inhibition as a lipid-lowering therapy.Adekunle AlabiXiao-Dan XiaHong-Mei GuFaqi WangShi-Jun DengNana YangAyinuer AdijiangDonna N. DouglasNorman M. KnetemanYazhuo XueLi ChenShucun QinGuiqing WangDa-Wei ZhangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Adekunle Alabi Xiao-Dan Xia Hong-Mei Gu Faqi Wang Shi-Jun Deng Nana Yang Ayinuer Adijiang Donna N. Douglas Norman M. Kneteman Yazhuo Xue Li Chen Shucun Qin Guiqing Wang Da-Wei Zhang Membrane type 1 matrix metalloproteinase promotes LDL receptor shedding and accelerates the development of atherosclerosis
description	Elevated plasma LDL cholesterol levels increase the risk of atherosclerotic cardiovascular disease. Here, the authors show that inhibition of MT1-MMP reduces plasma LDL cholesterol levels and the risk of atherosclerosis, indicating the potential of MT1-MMP inhibition as a lipid-lowering therapy.
format	article
author	Adekunle Alabi Xiao-Dan Xia Hong-Mei Gu Faqi Wang Shi-Jun Deng Nana Yang Ayinuer Adijiang Donna N. Douglas Norman M. Kneteman Yazhuo Xue Li Chen Shucun Qin Guiqing Wang Da-Wei Zhang
author_facet	Adekunle Alabi Xiao-Dan Xia Hong-Mei Gu Faqi Wang Shi-Jun Deng Nana Yang Ayinuer Adijiang Donna N. Douglas Norman M. Kneteman Yazhuo Xue Li Chen Shucun Qin Guiqing Wang Da-Wei Zhang
author_sort	Adekunle Alabi
title	Membrane type 1 matrix metalloproteinase promotes LDL receptor shedding and accelerates the development of atherosclerosis
title_short	Membrane type 1 matrix metalloproteinase promotes LDL receptor shedding and accelerates the development of atherosclerosis
title_full	Membrane type 1 matrix metalloproteinase promotes LDL receptor shedding and accelerates the development of atherosclerosis
title_fullStr	Membrane type 1 matrix metalloproteinase promotes LDL receptor shedding and accelerates the development of atherosclerosis
title_full_unstemmed	Membrane type 1 matrix metalloproteinase promotes LDL receptor shedding and accelerates the development of atherosclerosis
title_sort	membrane type 1 matrix metalloproteinase promotes ldl receptor shedding and accelerates the development of atherosclerosis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d72c4682bad4414eafe52c4f12f492db
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Membrane type 1 matrix metalloproteinase promotes LDL receptor shedding and accelerates the development of atherosclerosis

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