Plasma membrane coenzyme Q: evidence for a role in autism

Frederick L Crane,1 Hans Löw,2 Iris Sun,1 Placido Navas,3 Anna Gvozdjáková41Department of Biological Sciences, Purdue University, West Lafayette, IN, USA; 2Department of Molecular Medicine, Karolinska Institute, Stockholm, Sweden; 3Centro Andaluz de Biologí...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Crane FL, Löw H, Sun I, Navas P, Gvozdjáková A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/d72e4adb59264f4fa956c9bd5cad846e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d72e4adb59264f4fa956c9bd5cad846e
record_format	dspace
spelling	oai:doaj.org-article:d72e4adb59264f4fa956c9bd5cad846e2021-12-02T08:44:21ZPlasma membrane coenzyme Q: evidence for a role in autism1177-5475https://doaj.org/article/d72e4adb59264f4fa956c9bd5cad846e2014-05-01T00:00:00Zhttp://www.dovepress.com/plasma-membrane-coenzyme-q-evidence-for-a-role-in-autism-a17046https://doaj.org/toc/1177-5475 Frederick L Crane,1 Hans Löw,2 Iris Sun,1 Placido Navas,3 Anna Gvozdjáková41Department of Biological Sciences, Purdue University, West Lafayette, IN, USA; 2Department of Molecular Medicine, Karolinska Institute, Stockholm, Sweden; 3Centro Andaluz de Biología del Desarrollo, Universidad Pablo de Olavide, Sevilla, Spain; 4Pharmacobiochemical Laboratory of Third Medical Department, Medical Faculty, Comenius University in Bratislava, Bratislava, SlovakiaBackground: The Voltage Dependent Anion Channel (VDAC) is involved in control of autism. Treatments, including coenzyme Q, have had some success on autism control.Data sources: Correlation of porin redox activity and expression of autism is based on extensive literature, especially studies of antibodies, identification of cytosolic nicotinamide adenine dinucleotide reduced (NADH) dehydrogenase activity in the VDAC, and evidence for extreme sensitivity of the dehydrogenase to a mercurial. Evidence for a coenzyme Q requirement came from extraction and analog inhibition of NADH ferricyanide reductase in the erythrocyte plasma membrane, done in 1994, and reinterpreted when it was identified in VDAC in 2004. The effects of ubiquinol (the QH2 – reduced form of coenzyme Q) in children with autism were studied.Results: A new role for coenzyme Q in the porin channels has implications on autism. Ubiquinol, the more active form of coenzyme Q, produces favorable response in children with autism. Agents which affected electron transport in porin show parallel effects in autism.Conclusion: We propose a hypothesis that autism is controlled by a coenzyme Q-dependent redox system in the porin channels; this conclusion is based on the effects of agents that positively or negatively affect electron transport and the symptoms of autism. The full understanding of the mechanism of their control needs to be established.Keywords: porin, channel, oxidation, reduction, autismCrane FLLöw HSun INavas PGvozdjáková ADove Medical PressarticleMedicine (General)R5-920ENBiologics: Targets & Therapy, Vol 2014, Iss default, Pp 199-205 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Crane FL Löw H Sun I Navas P Gvozdjáková A Plasma membrane coenzyme Q: evidence for a role in autism
description	Frederick L Crane,1 Hans Löw,2 Iris Sun,1 Placido Navas,3 Anna Gvozdjáková41Department of Biological Sciences, Purdue University, West Lafayette, IN, USA; 2Department of Molecular Medicine, Karolinska Institute, Stockholm, Sweden; 3Centro Andaluz de Biología del Desarrollo, Universidad Pablo de Olavide, Sevilla, Spain; 4Pharmacobiochemical Laboratory of Third Medical Department, Medical Faculty, Comenius University in Bratislava, Bratislava, SlovakiaBackground: The Voltage Dependent Anion Channel (VDAC) is involved in control of autism. Treatments, including coenzyme Q, have had some success on autism control.Data sources: Correlation of porin redox activity and expression of autism is based on extensive literature, especially studies of antibodies, identification of cytosolic nicotinamide adenine dinucleotide reduced (NADH) dehydrogenase activity in the VDAC, and evidence for extreme sensitivity of the dehydrogenase to a mercurial. Evidence for a coenzyme Q requirement came from extraction and analog inhibition of NADH ferricyanide reductase in the erythrocyte plasma membrane, done in 1994, and reinterpreted when it was identified in VDAC in 2004. The effects of ubiquinol (the QH2 – reduced form of coenzyme Q) in children with autism were studied.Results: A new role for coenzyme Q in the porin channels has implications on autism. Ubiquinol, the more active form of coenzyme Q, produces favorable response in children with autism. Agents which affected electron transport in porin show parallel effects in autism.Conclusion: We propose a hypothesis that autism is controlled by a coenzyme Q-dependent redox system in the porin channels; this conclusion is based on the effects of agents that positively or negatively affect electron transport and the symptoms of autism. The full understanding of the mechanism of their control needs to be established.Keywords: porin, channel, oxidation, reduction, autism
format	article
author	Crane FL Löw H Sun I Navas P Gvozdjáková A
author_facet	Crane FL Löw H Sun I Navas P Gvozdjáková A
author_sort	Crane FL
title	Plasma membrane coenzyme Q: evidence for a role in autism
title_short	Plasma membrane coenzyme Q: evidence for a role in autism
title_full	Plasma membrane coenzyme Q: evidence for a role in autism
title_fullStr	Plasma membrane coenzyme Q: evidence for a role in autism
title_full_unstemmed	Plasma membrane coenzyme Q: evidence for a role in autism
title_sort	plasma membrane coenzyme q: evidence for a role in autism
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/d72e4adb59264f4fa956c9bd5cad846e
work_keys_str_mv	AT cranefl plasmamembranecoenzymeqevidenceforaroleinautism AT loumlwh plasmamembranecoenzymeqevidenceforaroleinautism AT suni plasmamembranecoenzymeqevidenceforaroleinautism AT navasp plasmamembranecoenzymeqevidenceforaroleinautism AT gvozdjaacutekovaacutea plasmamembranecoenzymeqevidenceforaroleinautism
_version_	1718398436470947840

Plasma membrane coenzyme Q: evidence for a role in autism

Ejemplares similares