CSF VEGF Was Positively Associated with Neurogranin Independent of β-Amyloid Pathology

CSF VEGF Was Positively Associated with Neurogranin Independent of β-Amyloid Pathology

Yangping Huang, Jun Wang, Bihong Zhu, Pan Fu Department of Neurology, Taizhou First People’s Hospital, Taizhou, Zhejiang, People’s Republic of ChinaCorrespondence: Pan Fu Email fp7154515@163.comPurpose: Increasing evidence suggests that both vascular endothelial growth factor (VE...

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Autores principales: Huang Y, Wang J, Zhu B, Fu P
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2020
Materias:
vascular endothelial growth factor
neurogranin
synaptic dysfunction
alzheimer’s disease.
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Acceso en línea:https://doaj.org/article/d72ef07c988845cb9c39aa854244c226
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spelling oai:doaj.org-article:d72ef07c988845cb9c39aa854244c2262021-12-02T10:43:35ZCSF VEGF Was Positively Associated with Neurogranin Independent of β-Amyloid Pathology1178-2021https://doaj.org/article/d72ef07c988845cb9c39aa854244c2262020-07-01T00:00:00Zhttps://www.dovepress.com/csf-vegf-was-positively-associated-with-neurogranin-independent-of-bet-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Yangping Huang, Jun Wang, Bihong Zhu, Pan Fu Department of Neurology, Taizhou First People’s Hospital, Taizhou, Zhejiang, People’s Republic of ChinaCorrespondence: Pan Fu Email fp7154515@163.comPurpose: Increasing evidence suggests that both vascular endothelial growth factor (VEGF) and synaptic failure have been involved in the pathogenesis of Alzheimer’s disease (AD). However, it is not clear whether CSF VEGF levels are associated with synaptic function in living human.Patients and Methods: In the present study, we included a total of 291 older individuals, including 83 individuals with normal cognition (NC), 143 individuals with mild cognitive impairment (MCI) and 65 patients with AD. Several linear regression models were conducted to examine the associations of CSF VEGF with CSF neurogranin levels (NG, reflecting synaptic degeneration) when controlling for other potential confounding factors, including age, gender, years of education, clinical diagnosis, APOE4 genotype and CSF β-amyloid 42 (Aβ 42) levels.Results: There was no significant difference in VEGF levels between the three diagnostic groups. In the pooled sample, females had significantly lower levels of VEGF than males. Aβ-positive (CSF Aβ 42 < 192 pg/mL) individuals had lower levels of VEGF than Aβ-negative individuals. However, the relationships between VEGF and NG levels were not modified by disease stage. Finally, we found that CSF VEGF levels were associated with NG levels with adjustment of age, gender, years of education, clinical diagnosis, APOE4 genotype and CSF Aβ 42 levels.Conclusion: CSF VEGF levels were associated with NG independent of AD pathology and disease stage.Keywords: vascular endothelial growth factor, neurogranin, synaptic dysfunction, Alzheimer’s diseaseHuang YWang JZhu BFu PDove Medical Pressarticlevascular endothelial growth factorneurograninsynaptic dysfunctionalzheimer’s disease.Neurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 16, Pp 1737-1744 (2020)
institution DOAJ
collection DOAJ
language EN
topic vascular endothelial growth factor
neurogranin
synaptic dysfunction
alzheimer’s disease.
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
spellingShingle vascular endothelial growth factor
neurogranin
synaptic dysfunction
alzheimer’s disease.
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Huang Y
Wang J
Zhu B
Fu P
CSF VEGF Was Positively Associated with Neurogranin Independent of β-Amyloid Pathology
description Yangping Huang, Jun Wang, Bihong Zhu, Pan Fu Department of Neurology, Taizhou First People’s Hospital, Taizhou, Zhejiang, People’s Republic of ChinaCorrespondence: Pan Fu Email fp7154515@163.comPurpose: Increasing evidence suggests that both vascular endothelial growth factor (VEGF) and synaptic failure have been involved in the pathogenesis of Alzheimer’s disease (AD). However, it is not clear whether CSF VEGF levels are associated with synaptic function in living human.Patients and Methods: In the present study, we included a total of 291 older individuals, including 83 individuals with normal cognition (NC), 143 individuals with mild cognitive impairment (MCI) and 65 patients with AD. Several linear regression models were conducted to examine the associations of CSF VEGF with CSF neurogranin levels (NG, reflecting synaptic degeneration) when controlling for other potential confounding factors, including age, gender, years of education, clinical diagnosis, APOE4 genotype and CSF β-amyloid 42 (Aβ 42) levels.Results: There was no significant difference in VEGF levels between the three diagnostic groups. In the pooled sample, females had significantly lower levels of VEGF than males. Aβ-positive (CSF Aβ 42 < 192 pg/mL) individuals had lower levels of VEGF than Aβ-negative individuals. However, the relationships between VEGF and NG levels were not modified by disease stage. Finally, we found that CSF VEGF levels were associated with NG levels with adjustment of age, gender, years of education, clinical diagnosis, APOE4 genotype and CSF Aβ 42 levels.Conclusion: CSF VEGF levels were associated with NG independent of AD pathology and disease stage.Keywords: vascular endothelial growth factor, neurogranin, synaptic dysfunction, Alzheimer’s disease
format article
author Huang Y
Wang J
Zhu B
Fu P
author_facet Huang Y
Wang J
Zhu B
Fu P
author_sort Huang Y
title CSF VEGF Was Positively Associated with Neurogranin Independent of β-Amyloid Pathology
title_short CSF VEGF Was Positively Associated with Neurogranin Independent of β-Amyloid Pathology
title_full CSF VEGF Was Positively Associated with Neurogranin Independent of β-Amyloid Pathology
title_fullStr CSF VEGF Was Positively Associated with Neurogranin Independent of β-Amyloid Pathology
title_full_unstemmed CSF VEGF Was Positively Associated with Neurogranin Independent of β-Amyloid Pathology
title_sort csf vegf was positively associated with neurogranin independent of β-amyloid pathology
publisher Dove Medical Press
publishDate 2020
url https://doaj.org/article/d72ef07c988845cb9c39aa854244c226
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AT zhub csfvegfwaspositivelyassociatedwithneurograninindependentofbetaamyloidpathology
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