SOME FEATURES OF IMMUNE REGULATION IN PATIENTS WITH FIBROUS/CAVERNOUS PULMONARY TUBERCULOSIS
Abstract. The study dealt with subpopulation analysis of peripheral blood T-regulatory cells (Treg), and in vitro testing of immunosuppressive cytokine (IL-10, TGF-β) production in the patients with fibrous/cavernous pulmonary tuberculosis, depending on results of intracutaneous tubercu...
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oai:doaj.org-article:d72fd073b8484071b00ed9ab7f2ae7e52021-11-18T08:03:42ZSOME FEATURES OF IMMUNE REGULATION IN PATIENTS WITH FIBROUS/CAVERNOUS PULMONARY TUBERCULOSIS1563-06252313-741X10.15789/1563-0625-2011-2-3-267-272https://doaj.org/article/d72fd073b8484071b00ed9ab7f2ae7e52014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/526https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. The study dealt with subpopulation analysis of peripheral blood T-regulatory cells (Treg), and in vitro testing of immunosuppressive cytokine (IL-10, TGF-β) production in the patients with fibrous/cavernous pulmonary tuberculosis, depending on results of intracutaneous tuberculin tests (Mantoux test). We have shown that Trn, natural T-regulatory lymphocytes (CD4+CD25+FoxP3+), and TGF-β cytokine, produced by these cells, play a leading role for immune suppression developing in fibrosis-cavernous pulmonary tuberculosis. Moreover, an imbalance of Treg cell subsets has been revealed in patients with fibrous/ cavernous pulmonary tuberculosis, with either positive, or negative Mantoux reaction, as shown by increased content of Treg cells with CD4+CD25+FoxP3+ phenotype, along with higher amounts of CD4+CD25-FoxP3+ subpopulations, and deficiency of CD4+CD25+FoxP3- Treg lymphocytes in blood samples (in cases of positive Mantoux tests). Increased amounts of CD4+CD25+FoxP3+ Treg cells in peripheral blood of patients with fibrous/cavernous pulmonary tuberculosis is associated with increase in basal and BCG-induced TGF-β production, and decreased in vitro IL-10 secretory potential. (Med. Immunol., 2011, vol. 13, N 2-3, pp 267-272)E. G. ChurinaV. V. NovitskiyO. I. UrazovaA. E. KolosovaO. V. VoronkovaO. V. FilinjukE. V. NekrasovI. E. YesimovaR. R. KhasanovaSPb RAACIarticletreg lymphocytesimmunosuppressive cytokinestuberculosis.Immunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 13, Iss 2-3, Pp 267-272 (2014) |
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treg lymphocytes immunosuppressive cytokines tuberculosis. Immunologic diseases. Allergy RC581-607 |
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treg lymphocytes immunosuppressive cytokines tuberculosis. Immunologic diseases. Allergy RC581-607 E. G. Churina V. V. Novitskiy O. I. Urazova A. E. Kolosova O. V. Voronkova O. V. Filinjuk E. V. Nekrasov I. E. Yesimova R. R. Khasanova SOME FEATURES OF IMMUNE REGULATION IN PATIENTS WITH FIBROUS/CAVERNOUS PULMONARY TUBERCULOSIS |
description |
Abstract. The study dealt with subpopulation analysis of peripheral blood T-regulatory cells (Treg), and in vitro testing of immunosuppressive cytokine (IL-10, TGF-β) production in the patients with fibrous/cavernous pulmonary tuberculosis, depending on results of intracutaneous tuberculin tests (Mantoux test). We have shown that Trn, natural T-regulatory lymphocytes (CD4+CD25+FoxP3+), and TGF-β cytokine, produced by these cells, play a leading role for immune suppression developing in fibrosis-cavernous pulmonary tuberculosis. Moreover, an imbalance of Treg cell subsets has been revealed in patients with fibrous/ cavernous pulmonary tuberculosis, with either positive, or negative Mantoux reaction, as shown by increased content of Treg cells with CD4+CD25+FoxP3+ phenotype, along with higher amounts of CD4+CD25-FoxP3+ subpopulations, and deficiency of CD4+CD25+FoxP3- Treg lymphocytes in blood samples (in cases of positive Mantoux tests). Increased amounts of CD4+CD25+FoxP3+ Treg cells in peripheral blood of patients with fibrous/cavernous pulmonary tuberculosis is associated with increase in basal and BCG-induced TGF-β production, and decreased in vitro IL-10 secretory potential. (Med. Immunol., 2011, vol. 13, N 2-3, pp 267-272) |
format |
article |
author |
E. G. Churina V. V. Novitskiy O. I. Urazova A. E. Kolosova O. V. Voronkova O. V. Filinjuk E. V. Nekrasov I. E. Yesimova R. R. Khasanova |
author_facet |
E. G. Churina V. V. Novitskiy O. I. Urazova A. E. Kolosova O. V. Voronkova O. V. Filinjuk E. V. Nekrasov I. E. Yesimova R. R. Khasanova |
author_sort |
E. G. Churina |
title |
SOME FEATURES OF IMMUNE REGULATION IN PATIENTS WITH FIBROUS/CAVERNOUS PULMONARY TUBERCULOSIS |
title_short |
SOME FEATURES OF IMMUNE REGULATION IN PATIENTS WITH FIBROUS/CAVERNOUS PULMONARY TUBERCULOSIS |
title_full |
SOME FEATURES OF IMMUNE REGULATION IN PATIENTS WITH FIBROUS/CAVERNOUS PULMONARY TUBERCULOSIS |
title_fullStr |
SOME FEATURES OF IMMUNE REGULATION IN PATIENTS WITH FIBROUS/CAVERNOUS PULMONARY TUBERCULOSIS |
title_full_unstemmed |
SOME FEATURES OF IMMUNE REGULATION IN PATIENTS WITH FIBROUS/CAVERNOUS PULMONARY TUBERCULOSIS |
title_sort |
some features of immune regulation in patients with fibrous/cavernous pulmonary tuberculosis |
publisher |
SPb RAACI |
publishDate |
2014 |
url |
https://doaj.org/article/d72fd073b8484071b00ed9ab7f2ae7e5 |
work_keys_str_mv |
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