SOME FEATURES OF IMMUNE REGULATION IN PATIENTS WITH FIBROUS/CAVERNOUS PULMONARY TUBERCULOSIS

Abstract. The study dealt with subpopulation analysis of peripheral blood T-regulatory cells (Treg), and in  vitro  testing  of  immunosuppressive  cytokine  (IL-10,  TGF-β)  production  in  the  patients  with  fibrous/cavernous pulmonary tuberculosis, depending on results of intracutaneous tubercu...

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Autores principales: E. G. Churina, V. V. Novitskiy, O. I. Urazova, A. E. Kolosova, O. V. Voronkova, O. V. Filinjuk, E. V. Nekrasov, I. E. Yesimova, R. R. Khasanova
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Publicado: SPb RAACI 2014
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spelling oai:doaj.org-article:d72fd073b8484071b00ed9ab7f2ae7e52021-11-18T08:03:42ZSOME FEATURES OF IMMUNE REGULATION IN PATIENTS WITH FIBROUS/CAVERNOUS PULMONARY TUBERCULOSIS1563-06252313-741X10.15789/1563-0625-2011-2-3-267-272https://doaj.org/article/d72fd073b8484071b00ed9ab7f2ae7e52014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/526https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. The study dealt with subpopulation analysis of peripheral blood T-regulatory cells (Treg), and in  vitro  testing  of  immunosuppressive  cytokine  (IL-10,  TGF-β)  production  in  the  patients  with  fibrous/cavernous pulmonary tuberculosis, depending on results of intracutaneous tuberculin tests (Mantoux test). We  have  shown  that  Trn,  natural  T-regulatory  lymphocytes  (CD4+CD25+FoxP3+),  and  TGF-β  cytokine, produced by these cells, play a leading role for immune suppression developing in fibrosis-cavernous pulmonary tuberculosis. Moreover, an imbalance of Treg cell subsets has been revealed in patients with fibrous/ cavernous pulmonary tuberculosis, with either positive, or negative Mantoux reaction, as shown by increased content of Treg cells with CD4+CD25+FoxP3+ phenotype, along with higher amounts of CD4+CD25-FoxP3+ subpopulations, and deficiency of CD4+CD25+FoxP3- Treg lymphocytes in blood samples (in cases of positive Mantoux tests). Increased amounts of CD4+CD25+FoxP3+ Treg cells in peripheral blood of patients with fibrous/cavernous pulmonary  tuberculosis  is  associated  with  increase  in  basal  and  BCG-induced  TGF-β  production,  and decreased in vitro IL-10 secretory potential. (Med. Immunol., 2011, vol. 13, N 2-3, pp 267-272)E. G. ChurinaV. V. NovitskiyO. I. UrazovaA. E. KolosovaO. V. VoronkovaO. V. FilinjukE. V. NekrasovI. E. YesimovaR. R. KhasanovaSPb RAACIarticletreg lymphocytesimmunosuppressive cytokinestuberculosis.Immunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 13, Iss 2-3, Pp 267-272 (2014)
institution DOAJ
collection DOAJ
language RU
topic treg lymphocytes
immunosuppressive cytokines
tuberculosis.
Immunologic diseases. Allergy
RC581-607
spellingShingle treg lymphocytes
immunosuppressive cytokines
tuberculosis.
Immunologic diseases. Allergy
RC581-607
E. G. Churina
V. V. Novitskiy
O. I. Urazova
A. E. Kolosova
O. V. Voronkova
O. V. Filinjuk
E. V. Nekrasov
I. E. Yesimova
R. R. Khasanova
SOME FEATURES OF IMMUNE REGULATION IN PATIENTS WITH FIBROUS/CAVERNOUS PULMONARY TUBERCULOSIS
description Abstract. The study dealt with subpopulation analysis of peripheral blood T-regulatory cells (Treg), and in  vitro  testing  of  immunosuppressive  cytokine  (IL-10,  TGF-β)  production  in  the  patients  with  fibrous/cavernous pulmonary tuberculosis, depending on results of intracutaneous tuberculin tests (Mantoux test). We  have  shown  that  Trn,  natural  T-regulatory  lymphocytes  (CD4+CD25+FoxP3+),  and  TGF-β  cytokine, produced by these cells, play a leading role for immune suppression developing in fibrosis-cavernous pulmonary tuberculosis. Moreover, an imbalance of Treg cell subsets has been revealed in patients with fibrous/ cavernous pulmonary tuberculosis, with either positive, or negative Mantoux reaction, as shown by increased content of Treg cells with CD4+CD25+FoxP3+ phenotype, along with higher amounts of CD4+CD25-FoxP3+ subpopulations, and deficiency of CD4+CD25+FoxP3- Treg lymphocytes in blood samples (in cases of positive Mantoux tests). Increased amounts of CD4+CD25+FoxP3+ Treg cells in peripheral blood of patients with fibrous/cavernous pulmonary  tuberculosis  is  associated  with  increase  in  basal  and  BCG-induced  TGF-β  production,  and decreased in vitro IL-10 secretory potential. (Med. Immunol., 2011, vol. 13, N 2-3, pp 267-272)
format article
author E. G. Churina
V. V. Novitskiy
O. I. Urazova
A. E. Kolosova
O. V. Voronkova
O. V. Filinjuk
E. V. Nekrasov
I. E. Yesimova
R. R. Khasanova
author_facet E. G. Churina
V. V. Novitskiy
O. I. Urazova
A. E. Kolosova
O. V. Voronkova
O. V. Filinjuk
E. V. Nekrasov
I. E. Yesimova
R. R. Khasanova
author_sort E. G. Churina
title SOME FEATURES OF IMMUNE REGULATION IN PATIENTS WITH FIBROUS/CAVERNOUS PULMONARY TUBERCULOSIS
title_short SOME FEATURES OF IMMUNE REGULATION IN PATIENTS WITH FIBROUS/CAVERNOUS PULMONARY TUBERCULOSIS
title_full SOME FEATURES OF IMMUNE REGULATION IN PATIENTS WITH FIBROUS/CAVERNOUS PULMONARY TUBERCULOSIS
title_fullStr SOME FEATURES OF IMMUNE REGULATION IN PATIENTS WITH FIBROUS/CAVERNOUS PULMONARY TUBERCULOSIS
title_full_unstemmed SOME FEATURES OF IMMUNE REGULATION IN PATIENTS WITH FIBROUS/CAVERNOUS PULMONARY TUBERCULOSIS
title_sort some features of immune regulation in patients with fibrous/cavernous pulmonary tuberculosis
publisher SPb RAACI
publishDate 2014
url https://doaj.org/article/d72fd073b8484071b00ed9ab7f2ae7e5
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