Histone variant H2A.J accumulates in senescent cells and promotes inflammatory gene expression

Senescence of mammalian cells is characterized by proliferative arrest and expression of an inflammatory phenotype. Here the authors show the H2A variant H2A.J, found only in mammals, accumulates following persistent DNA damage or natural aging.

Guardado en:

Detalles Bibliográficos
Autores principales:	Kévin Contrepois, Clément Coudereau, Bérénice A. Benayoun, Nadine Schuler, Pierre-François Roux, Oliver Bischof, Régis Courbeyrette, Cyril Carvalho, Jean-Yves Thuret, Zhihai Ma, Céline Derbois, Marie-Claire Nevers, Hervé Volland, Christophe E. Redon, William M. Bonner, Jean-François Deleuze, Clotilde Wiel, David Bernard, Michael P. Snyder, Claudia E. Rübe, Robert Olaso, François Fenaille, Carl Mann
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d72fdc8a41414edbbb502f55ed36f498
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d72fdc8a41414edbbb502f55ed36f498
record_format	dspace
spelling	oai:doaj.org-article:d72fdc8a41414edbbb502f55ed36f4982021-12-02T15:38:56ZHistone variant H2A.J accumulates in senescent cells and promotes inflammatory gene expression10.1038/ncomms149952041-1723https://doaj.org/article/d72fdc8a41414edbbb502f55ed36f4982017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms14995https://doaj.org/toc/2041-1723Senescence of mammalian cells is characterized by proliferative arrest and expression of an inflammatory phenotype. Here the authors show the H2A variant H2A.J, found only in mammals, accumulates following persistent DNA damage or natural aging.Kévin ContrepoisClément CoudereauBérénice A. BenayounNadine SchulerPierre-François RouxOliver BischofRégis CourbeyretteCyril CarvalhoJean-Yves ThuretZhihai MaCéline DerboisMarie-Claire NeversHervé VollandChristophe E. RedonWilliam M. BonnerJean-François DeleuzeClotilde WielDavid BernardMichael P. SnyderClaudia E. RübeRobert OlasoFrançois FenailleCarl MannNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-18 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kévin Contrepois Clément Coudereau Bérénice A. Benayoun Nadine Schuler Pierre-François Roux Oliver Bischof Régis Courbeyrette Cyril Carvalho Jean-Yves Thuret Zhihai Ma Céline Derbois Marie-Claire Nevers Hervé Volland Christophe E. Redon William M. Bonner Jean-François Deleuze Clotilde Wiel David Bernard Michael P. Snyder Claudia E. Rübe Robert Olaso François Fenaille Carl Mann Histone variant H2A.J accumulates in senescent cells and promotes inflammatory gene expression
description	Senescence of mammalian cells is characterized by proliferative arrest and expression of an inflammatory phenotype. Here the authors show the H2A variant H2A.J, found only in mammals, accumulates following persistent DNA damage or natural aging.
format	article
author	Kévin Contrepois Clément Coudereau Bérénice A. Benayoun Nadine Schuler Pierre-François Roux Oliver Bischof Régis Courbeyrette Cyril Carvalho Jean-Yves Thuret Zhihai Ma Céline Derbois Marie-Claire Nevers Hervé Volland Christophe E. Redon William M. Bonner Jean-François Deleuze Clotilde Wiel David Bernard Michael P. Snyder Claudia E. Rübe Robert Olaso François Fenaille Carl Mann
author_facet	Kévin Contrepois Clément Coudereau Bérénice A. Benayoun Nadine Schuler Pierre-François Roux Oliver Bischof Régis Courbeyrette Cyril Carvalho Jean-Yves Thuret Zhihai Ma Céline Derbois Marie-Claire Nevers Hervé Volland Christophe E. Redon William M. Bonner Jean-François Deleuze Clotilde Wiel David Bernard Michael P. Snyder Claudia E. Rübe Robert Olaso François Fenaille Carl Mann
author_sort	Kévin Contrepois
title	Histone variant H2A.J accumulates in senescent cells and promotes inflammatory gene expression
title_short	Histone variant H2A.J accumulates in senescent cells and promotes inflammatory gene expression
title_full	Histone variant H2A.J accumulates in senescent cells and promotes inflammatory gene expression
title_fullStr	Histone variant H2A.J accumulates in senescent cells and promotes inflammatory gene expression
title_full_unstemmed	Histone variant H2A.J accumulates in senescent cells and promotes inflammatory gene expression
title_sort	histone variant h2a.j accumulates in senescent cells and promotes inflammatory gene expression
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/d72fdc8a41414edbbb502f55ed36f498
work_keys_str_mv	AT kevincontrepois histonevarianth2ajaccumulatesinsenescentcellsandpromotesinflammatorygeneexpression AT clementcoudereau histonevarianth2ajaccumulatesinsenescentcellsandpromotesinflammatorygeneexpression AT bereniceabenayoun histonevarianth2ajaccumulatesinsenescentcellsandpromotesinflammatorygeneexpression AT nadineschuler histonevarianth2ajaccumulatesinsenescentcellsandpromotesinflammatorygeneexpression AT pierrefrancoisroux histonevarianth2ajaccumulatesinsenescentcellsandpromotesinflammatorygeneexpression AT oliverbischof histonevarianth2ajaccumulatesinsenescentcellsandpromotesinflammatorygeneexpression AT regiscourbeyrette histonevarianth2ajaccumulatesinsenescentcellsandpromotesinflammatorygeneexpression AT cyrilcarvalho histonevarianth2ajaccumulatesinsenescentcellsandpromotesinflammatorygeneexpression AT jeanyvesthuret histonevarianth2ajaccumulatesinsenescentcellsandpromotesinflammatorygeneexpression AT zhihaima histonevarianth2ajaccumulatesinsenescentcellsandpromotesinflammatorygeneexpression AT celinederbois histonevarianth2ajaccumulatesinsenescentcellsandpromotesinflammatorygeneexpression AT marieclairenevers histonevarianth2ajaccumulatesinsenescentcellsandpromotesinflammatorygeneexpression AT hervevolland histonevarianth2ajaccumulatesinsenescentcellsandpromotesinflammatorygeneexpression AT christopheeredon histonevarianth2ajaccumulatesinsenescentcellsandpromotesinflammatorygeneexpression AT williammbonner histonevarianth2ajaccumulatesinsenescentcellsandpromotesinflammatorygeneexpression AT jeanfrancoisdeleuze histonevarianth2ajaccumulatesinsenescentcellsandpromotesinflammatorygeneexpression AT clotildewiel histonevarianth2ajaccumulatesinsenescentcellsandpromotesinflammatorygeneexpression AT davidbernard histonevarianth2ajaccumulatesinsenescentcellsandpromotesinflammatorygeneexpression AT michaelpsnyder histonevarianth2ajaccumulatesinsenescentcellsandpromotesinflammatorygeneexpression AT claudiaerube histonevarianth2ajaccumulatesinsenescentcellsandpromotesinflammatorygeneexpression AT robertolaso histonevarianth2ajaccumulatesinsenescentcellsandpromotesinflammatorygeneexpression AT francoisfenaille histonevarianth2ajaccumulatesinsenescentcellsandpromotesinflammatorygeneexpression AT carlmann histonevarianth2ajaccumulatesinsenescentcellsandpromotesinflammatorygeneexpression
_version_	1718386077512761344

Histone variant H2A.J accumulates in senescent cells and promotes inflammatory gene expression

Ejemplares similares