Polymeric mechanical amplifiers of immune cytokine-mediated apoptosis

Fluid shear stress plays a critical role in receptor-mediated signalling and has been shown to sensitize cancer cells to apoptosis. Here, Mitchellet al. introduce polymer micro- and nanoparticles tethered to tumour cells to amplify fluid shear stress effects, and find that they can enhance immune cy...

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Autores principales:	Michael J. Mitchell, Jamie Webster, Amanda Chung, Pedro P. G. Guimarães, Omar F. Khan, Robert Langer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d730205456884197a323e8fe7afb2487
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spelling	oai:doaj.org-article:d730205456884197a323e8fe7afb24872021-12-02T14:42:05ZPolymeric mechanical amplifiers of immune cytokine-mediated apoptosis10.1038/ncomms141792041-1723https://doaj.org/article/d730205456884197a323e8fe7afb24872017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14179https://doaj.org/toc/2041-1723Fluid shear stress plays a critical role in receptor-mediated signalling and has been shown to sensitize cancer cells to apoptosis. Here, Mitchellet al. introduce polymer micro- and nanoparticles tethered to tumour cells to amplify fluid shear stress effects, and find that they can enhance immune cytokine-mediated apoptosis of tumour cells in vitro and in vivo.Michael J. MitchellJamie WebsterAmanda ChungPedro P. G. GuimarãesOmar F. KhanRobert LangerNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Michael J. Mitchell Jamie Webster Amanda Chung Pedro P. G. Guimarães Omar F. Khan Robert Langer Polymeric mechanical amplifiers of immune cytokine-mediated apoptosis
description	Fluid shear stress plays a critical role in receptor-mediated signalling and has been shown to sensitize cancer cells to apoptosis. Here, Mitchellet al. introduce polymer micro- and nanoparticles tethered to tumour cells to amplify fluid shear stress effects, and find that they can enhance immune cytokine-mediated apoptosis of tumour cells in vitro and in vivo.
format	article
author	Michael J. Mitchell Jamie Webster Amanda Chung Pedro P. G. Guimarães Omar F. Khan Robert Langer
author_facet	Michael J. Mitchell Jamie Webster Amanda Chung Pedro P. G. Guimarães Omar F. Khan Robert Langer
author_sort	Michael J. Mitchell
title	Polymeric mechanical amplifiers of immune cytokine-mediated apoptosis
title_short	Polymeric mechanical amplifiers of immune cytokine-mediated apoptosis
title_full	Polymeric mechanical amplifiers of immune cytokine-mediated apoptosis
title_fullStr	Polymeric mechanical amplifiers of immune cytokine-mediated apoptosis
title_full_unstemmed	Polymeric mechanical amplifiers of immune cytokine-mediated apoptosis
title_sort	polymeric mechanical amplifiers of immune cytokine-mediated apoptosis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/d730205456884197a323e8fe7afb2487
work_keys_str_mv	AT michaeljmitchell polymericmechanicalamplifiersofimmunecytokinemediatedapoptosis AT jamiewebster polymericmechanicalamplifiersofimmunecytokinemediatedapoptosis AT amandachung polymericmechanicalamplifiersofimmunecytokinemediatedapoptosis AT pedropgguimaraes polymericmechanicalamplifiersofimmunecytokinemediatedapoptosis AT omarfkhan polymericmechanicalamplifiersofimmunecytokinemediatedapoptosis AT robertlanger polymericmechanicalamplifiersofimmunecytokinemediatedapoptosis
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Polymeric mechanical amplifiers of immune cytokine-mediated apoptosis

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