Polymeric mechanical amplifiers of immune cytokine-mediated apoptosis
Fluid shear stress plays a critical role in receptor-mediated signalling and has been shown to sensitize cancer cells to apoptosis. Here, Mitchellet al. introduce polymer micro- and nanoparticles tethered to tumour cells to amplify fluid shear stress effects, and find that they can enhance immune cy...
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Autores principales: | Michael J. Mitchell, Jamie Webster, Amanda Chung, Pedro P. G. Guimarães, Omar F. Khan, Robert Langer |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2017
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Materias: | |
Acceso en línea: | https://doaj.org/article/d730205456884197a323e8fe7afb2487 |
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