Recent Advances in Developmental Hematopoiesis: Diving Deeper With New Technologies

The journey of a hematopoietic stem cell (HSC) involves the passage through successive anatomical sites where HSCs are in direct contact with their surrounding microenvironment, also known as niche. These spatial and temporal cellular interactions throughout development are required for the acquisit...

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Autores principales:	Bart Weijts, Laurent Yvernogeau, Catherine Robin
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	hematopoietic stem cells aorta-gonad-mesonephros microenvironment niche single cell RNA sequencing tomography sequencing Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/d7320bf7021448179df1c7b8ec24911e
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spelling	oai:doaj.org-article:d7320bf7021448179df1c7b8ec24911e2021-11-30T18:16:27ZRecent Advances in Developmental Hematopoiesis: Diving Deeper With New Technologies1664-322410.3389/fimmu.2021.790379https://doaj.org/article/d7320bf7021448179df1c7b8ec24911e2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.790379/fullhttps://doaj.org/toc/1664-3224The journey of a hematopoietic stem cell (HSC) involves the passage through successive anatomical sites where HSCs are in direct contact with their surrounding microenvironment, also known as niche. These spatial and temporal cellular interactions throughout development are required for the acquisition of stem cell properties, and for maintaining the HSC pool through balancing self-renewal, quiescence and lineage commitment. Understanding the context and consequences of these interactions will be imperative for our understanding of HSC biology and will lead to the improvement of in vitro production of HSCs for clinical purposes. The aorta-gonad-mesonephros (AGM) region is in this light of particular interest since this is the cradle of HSC emergence during the embryonic development of all vertebrate species. In this review, we will focus on the developmental origin of HSCs and will discuss the novel technological approaches and recent progress made to identify the cellular composition of the HSC supportive niche and the underlying molecular events occurring in the AGM region.Bart WeijtsLaurent YvernogeauCatherine RobinCatherine RobinFrontiers Media S.A.articlehematopoietic stem cellsaorta-gonad-mesonephrosmicroenvironmentnichesingle cell RNA sequencingtomography sequencingImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hematopoietic stem cells aorta-gonad-mesonephros microenvironment niche single cell RNA sequencing tomography sequencing Immunologic diseases. Allergy RC581-607
spellingShingle	hematopoietic stem cells aorta-gonad-mesonephros microenvironment niche single cell RNA sequencing tomography sequencing Immunologic diseases. Allergy RC581-607 Bart Weijts Laurent Yvernogeau Catherine Robin Catherine Robin Recent Advances in Developmental Hematopoiesis: Diving Deeper With New Technologies
description	The journey of a hematopoietic stem cell (HSC) involves the passage through successive anatomical sites where HSCs are in direct contact with their surrounding microenvironment, also known as niche. These spatial and temporal cellular interactions throughout development are required for the acquisition of stem cell properties, and for maintaining the HSC pool through balancing self-renewal, quiescence and lineage commitment. Understanding the context and consequences of these interactions will be imperative for our understanding of HSC biology and will lead to the improvement of in vitro production of HSCs for clinical purposes. The aorta-gonad-mesonephros (AGM) region is in this light of particular interest since this is the cradle of HSC emergence during the embryonic development of all vertebrate species. In this review, we will focus on the developmental origin of HSCs and will discuss the novel technological approaches and recent progress made to identify the cellular composition of the HSC supportive niche and the underlying molecular events occurring in the AGM region.
format	article
author	Bart Weijts Laurent Yvernogeau Catherine Robin Catherine Robin
author_facet	Bart Weijts Laurent Yvernogeau Catherine Robin Catherine Robin
author_sort	Bart Weijts
title	Recent Advances in Developmental Hematopoiesis: Diving Deeper With New Technologies
title_short	Recent Advances in Developmental Hematopoiesis: Diving Deeper With New Technologies
title_full	Recent Advances in Developmental Hematopoiesis: Diving Deeper With New Technologies
title_fullStr	Recent Advances in Developmental Hematopoiesis: Diving Deeper With New Technologies
title_full_unstemmed	Recent Advances in Developmental Hematopoiesis: Diving Deeper With New Technologies
title_sort	recent advances in developmental hematopoiesis: diving deeper with new technologies
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/d7320bf7021448179df1c7b8ec24911e
work_keys_str_mv	AT bartweijts recentadvancesindevelopmentalhematopoiesisdivingdeeperwithnewtechnologies AT laurentyvernogeau recentadvancesindevelopmentalhematopoiesisdivingdeeperwithnewtechnologies AT catherinerobin recentadvancesindevelopmentalhematopoiesisdivingdeeperwithnewtechnologies AT catherinerobin recentadvancesindevelopmentalhematopoiesisdivingdeeperwithnewtechnologies
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Recent Advances in Developmental Hematopoiesis: Diving Deeper With New Technologies

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