The detection of novelty relies on dopaminergic signaling: evidence from apomorphine's impact on the novelty N2.
Despite much research, it remains unclear if dopamine is directly involved in novelty detection or plays a role in orchestrating the subsequent cognitive response. This ambiguity stems in part from a reliance on experimental designs where novelty is manipulated and dopaminergic activity is subsequen...
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Public Library of Science (PLoS)
2013
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oai:doaj.org-article:d73455b954dd4df99ca9d238f68b1eb52021-11-18T07:40:47ZThe detection of novelty relies on dopaminergic signaling: evidence from apomorphine's impact on the novelty N2.1932-620310.1371/journal.pone.0066469https://doaj.org/article/d73455b954dd4df99ca9d238f68b1eb52013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23840482/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Despite much research, it remains unclear if dopamine is directly involved in novelty detection or plays a role in orchestrating the subsequent cognitive response. This ambiguity stems in part from a reliance on experimental designs where novelty is manipulated and dopaminergic activity is subsequently observed. Here we adopt the alternative approach: we manipulate dopamine activity using apomorphine (D1/D2 agonist) and measure the change in neurological indices of novelty processing. In separate drug and placebo sessions, participants completed a von Restorff task. Apomorphine speeded and potentiated the novelty-elicited N2, an Event-Related Potential (ERP) component thought to index early aspects of novelty detection, and caused novel-font words to be better recalled. Apomorphine also decreased the amplitude of the novelty-P3a. An increase in D1/D2 receptor activation thus appears to potentiate neural sensitivity to novel stimuli, causing this content to be better encoded.Mauricio Rangel-GomezClayton HickeyTherese van AmelsvoortPierre BetMartijn MeeterPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 6, p e66469 (2013) |
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Medicine R Science Q |
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Medicine R Science Q Mauricio Rangel-Gomez Clayton Hickey Therese van Amelsvoort Pierre Bet Martijn Meeter The detection of novelty relies on dopaminergic signaling: evidence from apomorphine's impact on the novelty N2. |
| description |
Despite much research, it remains unclear if dopamine is directly involved in novelty detection or plays a role in orchestrating the subsequent cognitive response. This ambiguity stems in part from a reliance on experimental designs where novelty is manipulated and dopaminergic activity is subsequently observed. Here we adopt the alternative approach: we manipulate dopamine activity using apomorphine (D1/D2 agonist) and measure the change in neurological indices of novelty processing. In separate drug and placebo sessions, participants completed a von Restorff task. Apomorphine speeded and potentiated the novelty-elicited N2, an Event-Related Potential (ERP) component thought to index early aspects of novelty detection, and caused novel-font words to be better recalled. Apomorphine also decreased the amplitude of the novelty-P3a. An increase in D1/D2 receptor activation thus appears to potentiate neural sensitivity to novel stimuli, causing this content to be better encoded. |
| format |
article |
| author |
Mauricio Rangel-Gomez Clayton Hickey Therese van Amelsvoort Pierre Bet Martijn Meeter |
| author_facet |
Mauricio Rangel-Gomez Clayton Hickey Therese van Amelsvoort Pierre Bet Martijn Meeter |
| author_sort |
Mauricio Rangel-Gomez |
| title |
The detection of novelty relies on dopaminergic signaling: evidence from apomorphine's impact on the novelty N2. |
| title_short |
The detection of novelty relies on dopaminergic signaling: evidence from apomorphine's impact on the novelty N2. |
| title_full |
The detection of novelty relies on dopaminergic signaling: evidence from apomorphine's impact on the novelty N2. |
| title_fullStr |
The detection of novelty relies on dopaminergic signaling: evidence from apomorphine's impact on the novelty N2. |
| title_full_unstemmed |
The detection of novelty relies on dopaminergic signaling: evidence from apomorphine's impact on the novelty N2. |
| title_sort |
detection of novelty relies on dopaminergic signaling: evidence from apomorphine's impact on the novelty n2. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2013 |
| url |
https://doaj.org/article/d73455b954dd4df99ca9d238f68b1eb5 |
| work_keys_str_mv |
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