Bactericidal metabolites from Phellinus noxius HN-1 against Microcystis aeruginosa

Abstract Harmful algal blooms cause serious problems worldwide due to large quantities of cyanotoxins produced by cyanobacteria in eutrophic water. In this study, a new compound named 2-(3, 4-dihydroxy-2-methoxyphenyl)-1, 3-benzodioxole-5-carbaldehyde (Compound 1), together with one known compound,...

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Autores principales:	Pengfei Jin, Haonan Wang, Wenbo Liu, Shujian Zhang, Chunhua Lin, Fucong Zheng, Weiguo Miao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d737c3e057544bdc957c86595f7d5da5
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spelling	oai:doaj.org-article:d737c3e057544bdc957c86595f7d5da52021-12-02T15:05:51ZBactericidal metabolites from Phellinus noxius HN-1 against Microcystis aeruginosa10.1038/s41598-017-03440-22045-2322https://doaj.org/article/d737c3e057544bdc957c86595f7d5da52017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03440-2https://doaj.org/toc/2045-2322Abstract Harmful algal blooms cause serious problems worldwide due to large quantities of cyanotoxins produced by cyanobacteria in eutrophic water. In this study, a new compound named 2-(3, 4-dihydroxy-2-methoxyphenyl)-1, 3-benzodioxole-5-carbaldehyde (Compound 1), together with one known compound, 3, 4-dihydroxybenzalacetone (DBL), was purified from Phellinus noxius HN-1 (CCTCC M 2016242). Compound 1 and DBL displayed activity against the cyanobacteria Microcystis aeruginosa with a half maximal effective concentration of 21 and 5 μg/mL, respectively. Scanning electron and transmission electron microscopic observations showed that the compounds caused serious damage and significant lysis to M. aeruginosa cells. qRT-PCR assay indicated that compound 1 and DBL exposure up-regulated the expression of gene mcyB and down-regulated the expression of genes ftsZ, psbA1, and glmS in M. aeruginosa. This study provides the first evidence of bactericidal activity of a new compound and DBL. In summary, our results suggest that compound 1 and DBL might be developed as naturally-based biocontrol agents.Pengfei JinHaonan WangWenbo LiuShujian ZhangChunhua LinFucong ZhengWeiguo MiaoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Pengfei Jin Haonan Wang Wenbo Liu Shujian Zhang Chunhua Lin Fucong Zheng Weiguo Miao Bactericidal metabolites from Phellinus noxius HN-1 against Microcystis aeruginosa
description	Abstract Harmful algal blooms cause serious problems worldwide due to large quantities of cyanotoxins produced by cyanobacteria in eutrophic water. In this study, a new compound named 2-(3, 4-dihydroxy-2-methoxyphenyl)-1, 3-benzodioxole-5-carbaldehyde (Compound 1), together with one known compound, 3, 4-dihydroxybenzalacetone (DBL), was purified from Phellinus noxius HN-1 (CCTCC M 2016242). Compound 1 and DBL displayed activity against the cyanobacteria Microcystis aeruginosa with a half maximal effective concentration of 21 and 5 μg/mL, respectively. Scanning electron and transmission electron microscopic observations showed that the compounds caused serious damage and significant lysis to M. aeruginosa cells. qRT-PCR assay indicated that compound 1 and DBL exposure up-regulated the expression of gene mcyB and down-regulated the expression of genes ftsZ, psbA1, and glmS in M. aeruginosa. This study provides the first evidence of bactericidal activity of a new compound and DBL. In summary, our results suggest that compound 1 and DBL might be developed as naturally-based biocontrol agents.
format	article
author	Pengfei Jin Haonan Wang Wenbo Liu Shujian Zhang Chunhua Lin Fucong Zheng Weiguo Miao
author_facet	Pengfei Jin Haonan Wang Wenbo Liu Shujian Zhang Chunhua Lin Fucong Zheng Weiguo Miao
author_sort	Pengfei Jin
title	Bactericidal metabolites from Phellinus noxius HN-1 against Microcystis aeruginosa
title_short	Bactericidal metabolites from Phellinus noxius HN-1 against Microcystis aeruginosa
title_full	Bactericidal metabolites from Phellinus noxius HN-1 against Microcystis aeruginosa
title_fullStr	Bactericidal metabolites from Phellinus noxius HN-1 against Microcystis aeruginosa
title_full_unstemmed	Bactericidal metabolites from Phellinus noxius HN-1 against Microcystis aeruginosa
title_sort	bactericidal metabolites from phellinus noxius hn-1 against microcystis aeruginosa
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/d737c3e057544bdc957c86595f7d5da5
work_keys_str_mv	AT pengfeijin bactericidalmetabolitesfromphellinusnoxiushn1againstmicrocystisaeruginosa AT haonanwang bactericidalmetabolitesfromphellinusnoxiushn1againstmicrocystisaeruginosa AT wenboliu bactericidalmetabolitesfromphellinusnoxiushn1againstmicrocystisaeruginosa AT shujianzhang bactericidalmetabolitesfromphellinusnoxiushn1againstmicrocystisaeruginosa AT chunhualin bactericidalmetabolitesfromphellinusnoxiushn1againstmicrocystisaeruginosa AT fucongzheng bactericidalmetabolitesfromphellinusnoxiushn1againstmicrocystisaeruginosa AT weiguomiao bactericidalmetabolitesfromphellinusnoxiushn1againstmicrocystisaeruginosa
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Bactericidal metabolites from Phellinus noxius HN-1 against Microcystis aeruginosa

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