Efficacy and safety of a switch to latanoprost 0.005% + timolol maleate 0.5% fixed combination eyedrops from latanoprost 0.005% monotherapy

Efficacy and safety of a switch to latanoprost 0.005% + timolol maleate 0.5% fixed combination eyedrops from latanoprost 0.005% monotherapy

Kenji Inoue,1 Takayuki Fujimoto,1 Risako Higa,1 Ryo Moriyama,1 Hiromi Kohmoto,1 Haruka Nagumo,1 Masato Wakakura,1 Goji Tomita21Inouye Eye Hospital, Chiyoda-ku, Tokyo, 2Second Department of Ophthalmology, Toho University School of Medicine, Meguro-ku, Tokyo, JapanBackground: The purpose of this prosp...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Inoue K, Fujimoto T, Higa R, Moriyama R, Kohmoto H, Nagumo H, Wakakura M, Tomita G
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2012
Materias:
Ophthalmology
RE1-994
Acceso en línea:https://doaj.org/article/d7396394d4dd4da983c6459d4d346c67
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:d7396394d4dd4da983c6459d4d346c67
record_format dspace
spelling oai:doaj.org-article:d7396394d4dd4da983c6459d4d346c672021-12-02T04:25:23ZEfficacy and safety of a switch to latanoprost 0.005% + timolol maleate 0.5% fixed combination eyedrops from latanoprost 0.005% monotherapy1177-54671177-5483https://doaj.org/article/d7396394d4dd4da983c6459d4d346c672012-05-01T00:00:00Zhttp://www.dovepress.com/efficacy-and-safety-of-a-switch-to-latanoprost-0005--timolol-maleate-0-a9933https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Kenji Inoue,1 Takayuki Fujimoto,1 Risako Higa,1 Ryo Moriyama,1 Hiromi Kohmoto,1 Haruka Nagumo,1 Masato Wakakura,1 Goji Tomita21Inouye Eye Hospital, Chiyoda-ku, Tokyo, 2Second Department of Ophthalmology, Toho University School of Medicine, Meguro-ku, Tokyo, JapanBackground: The purpose of this prospective study was to investigate the intraocular pressure (IOP)-lowering effect and safety of latanoprost 0.005% + timolol maleate 0.5% fixed combination eyedrops, now available in Japan.Materials and methods: Thirty-one patients diagnosed with primary open-angle glaucoma who had an insufficient intraocular pressure (IOP) decrease with latanoprost 0.005% eyedrop monotherapy were enrolled. The latanoprost 0.005% eyedrops were discontinued, and administration of latanoprost 0.005%/timolol maleate 0.5% fixed combination eyedrops was initiated without any washout period. IOP was compared before and at months 1, 3, and 6 after the switch. The incidence of adverse reactions was investigated at every follow-up visit.Results: Mean IOP was 17.3 ± 2.7 mmHg before the switch, 15.5 ± 2.6 mmHg one month after the switch, 14.9 ± 2.4 mmHg 3 months after the switch, and 15.1 ± 2.2 mmHg 6 months after the switch, indicating that IOP decreased significantly after the change. The IOP reduction rate was 9.9% ± 11.5% after one month, 13.1% ± 10.9% after 3 months, and 11.2% ± 11.8% after 6 months. Two patients (6.5%) discontinued therapy due to adverse reactions (one case each of itchiness and bradycardia).Conclusion: When latanoprost 0.005% eyedrop monotherapy was replaced by latanoprost 0.005% + timolol maleate 0.5% fixed combination eyedrops, IOP decreased significantly without increasing the frequency of administration, and safety was satisfactory.Keywords: latanoprost 0.005%, timolol maleate 0.5%, fixed combination, eyedrops, intraocular pressure, switchInoue KFujimoto THiga RMoriyama RKohmoto HNagumo HWakakura MTomita GDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2012, Iss default, Pp 771-775 (2012)
institution DOAJ
collection DOAJ
language EN
topic Ophthalmology
RE1-994
spellingShingle Ophthalmology
RE1-994
Inoue K
Fujimoto T
Higa R
Moriyama R
Kohmoto H
Nagumo H
Wakakura M
Tomita G
Efficacy and safety of a switch to latanoprost 0.005% + timolol maleate 0.5% fixed combination eyedrops from latanoprost 0.005% monotherapy
description Kenji Inoue,1 Takayuki Fujimoto,1 Risako Higa,1 Ryo Moriyama,1 Hiromi Kohmoto,1 Haruka Nagumo,1 Masato Wakakura,1 Goji Tomita21Inouye Eye Hospital, Chiyoda-ku, Tokyo, 2Second Department of Ophthalmology, Toho University School of Medicine, Meguro-ku, Tokyo, JapanBackground: The purpose of this prospective study was to investigate the intraocular pressure (IOP)-lowering effect and safety of latanoprost 0.005% + timolol maleate 0.5% fixed combination eyedrops, now available in Japan.Materials and methods: Thirty-one patients diagnosed with primary open-angle glaucoma who had an insufficient intraocular pressure (IOP) decrease with latanoprost 0.005% eyedrop monotherapy were enrolled. The latanoprost 0.005% eyedrops were discontinued, and administration of latanoprost 0.005%/timolol maleate 0.5% fixed combination eyedrops was initiated without any washout period. IOP was compared before and at months 1, 3, and 6 after the switch. The incidence of adverse reactions was investigated at every follow-up visit.Results: Mean IOP was 17.3 ± 2.7 mmHg before the switch, 15.5 ± 2.6 mmHg one month after the switch, 14.9 ± 2.4 mmHg 3 months after the switch, and 15.1 ± 2.2 mmHg 6 months after the switch, indicating that IOP decreased significantly after the change. The IOP reduction rate was 9.9% ± 11.5% after one month, 13.1% ± 10.9% after 3 months, and 11.2% ± 11.8% after 6 months. Two patients (6.5%) discontinued therapy due to adverse reactions (one case each of itchiness and bradycardia).Conclusion: When latanoprost 0.005% eyedrop monotherapy was replaced by latanoprost 0.005% + timolol maleate 0.5% fixed combination eyedrops, IOP decreased significantly without increasing the frequency of administration, and safety was satisfactory.Keywords: latanoprost 0.005%, timolol maleate 0.5%, fixed combination, eyedrops, intraocular pressure, switch
format article
author Inoue K
Fujimoto T
Higa R
Moriyama R
Kohmoto H
Nagumo H
Wakakura M
Tomita G
author_facet Inoue K
Fujimoto T
Higa R
Moriyama R
Kohmoto H
Nagumo H
Wakakura M
Tomita G
author_sort Inoue K
title Efficacy and safety of a switch to latanoprost 0.005% + timolol maleate 0.5% fixed combination eyedrops from latanoprost 0.005% monotherapy
title_short Efficacy and safety of a switch to latanoprost 0.005% + timolol maleate 0.5% fixed combination eyedrops from latanoprost 0.005% monotherapy
title_full Efficacy and safety of a switch to latanoprost 0.005% + timolol maleate 0.5% fixed combination eyedrops from latanoprost 0.005% monotherapy
title_fullStr Efficacy and safety of a switch to latanoprost 0.005% + timolol maleate 0.5% fixed combination eyedrops from latanoprost 0.005% monotherapy
title_full_unstemmed Efficacy and safety of a switch to latanoprost 0.005% + timolol maleate 0.5% fixed combination eyedrops from latanoprost 0.005% monotherapy
title_sort efficacy and safety of a switch to latanoprost 0.005% + timolol maleate 0.5% fixed combination eyedrops from latanoprost 0.005% monotherapy
publisher Dove Medical Press
publishDate 2012
url https://doaj.org/article/d7396394d4dd4da983c6459d4d346c67
work_keys_str_mv AT inouek efficacyandsafetyofaswitchtolatanoprost0005timololmaleate05fixedcombinationeyedropsfromlatanoprost0005monotherapy
AT fujimotot efficacyandsafetyofaswitchtolatanoprost0005timololmaleate05fixedcombinationeyedropsfromlatanoprost0005monotherapy
AT higar efficacyandsafetyofaswitchtolatanoprost0005timololmaleate05fixedcombinationeyedropsfromlatanoprost0005monotherapy
AT moriyamar efficacyandsafetyofaswitchtolatanoprost0005timololmaleate05fixedcombinationeyedropsfromlatanoprost0005monotherapy
AT kohmotoh efficacyandsafetyofaswitchtolatanoprost0005timololmaleate05fixedcombinationeyedropsfromlatanoprost0005monotherapy
AT nagumoh efficacyandsafetyofaswitchtolatanoprost0005timololmaleate05fixedcombinationeyedropsfromlatanoprost0005monotherapy
AT wakakuram efficacyandsafetyofaswitchtolatanoprost0005timololmaleate05fixedcombinationeyedropsfromlatanoprost0005monotherapy
AT tomitag efficacyandsafetyofaswitchtolatanoprost0005timololmaleate05fixedcombinationeyedropsfromlatanoprost0005monotherapy
_version_ 1718401276014755840

Ejemplares similares