Altered Spontaneous Brain Activity Related to Neurologic and Sleep Dysfunction in Children With Obstructive Sleep Apnea Syndrome

Childhood obstructive sleep apnea (OSA) is a common chronic sleep-related breathing disorder in children, which leads to growth retardation, neurocognitive impairments, and serious complications. Considering the previous studies about brain structural abnormalities in OSA, in the present study, we a...

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Autores principales:	Jie Bai, Hongwei Wen, Jun Tai, Yun Peng, Hongbin Li, Lin Mei, Tingting Ji, Xiaodan Li, Yanhua Li, Xin Ni, Yue Liu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	obstructive sleep apnea children amplitude of low-frequency fluctuation fractional regional homogeneity functional magnetic resonance imaging resting state Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/d73b54b804de4fcc8578d7518ca22ec2
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spelling	oai:doaj.org-article:d73b54b804de4fcc8578d7518ca22ec22021-11-15T07:51:26ZAltered Spontaneous Brain Activity Related to Neurologic and Sleep Dysfunction in Children With Obstructive Sleep Apnea Syndrome1662-453X10.3389/fnins.2021.595412https://doaj.org/article/d73b54b804de4fcc8578d7518ca22ec22021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnins.2021.595412/fullhttps://doaj.org/toc/1662-453XChildhood obstructive sleep apnea (OSA) is a common chronic sleep-related breathing disorder in children, which leads to growth retardation, neurocognitive impairments, and serious complications. Considering the previous studies about brain structural abnormalities in OSA, in the present study, we aimed to explore the altered spontaneous brain activity among OSA patients, using amplitude of low-frequency fluctuation (ALFF), fractional ALFF (fALFF), and regional homogeneity (ReHo) methods based on resting-state functional magnetic resonance imaging (MRI). Thirty-one untreated OSA children and 33 age-and gender-matched healthy children (HC) were included in this study. Compared with controls, the OSA group showed significant lower ALFF in the right lingual gyrus, decreased fALFF in the left middle frontal gyrus (MFG), but increased fALFF in the left precuneus. Decreased ReHo was found in the left inferior frontal gyrus (orbital part) and left middle frontal gyrus. Notably, the mean fALFF value of left MFG was not only significantly related to multiple sleep parameters but also demonstrated the best performance in ROC curve analysis. These findings revealed OSA children were associated with dysfunctions in the default mode network, the frontal lobe, and the lingual gyrus, which may implicate the underlying neurophysiological mechanisms of intrinsic brain activity. The correlation between the altered spontaneous neuronal activity and the clinical index provides early useful diagnostic biomarkers for OSA children as well.Jie BaiHongwei WenHongwei WenJun TaiYun PengHongbin LiLin MeiTingting JiXiaodan LiYanhua LiXin NiYue LiuFrontiers Media S.A.articleobstructive sleep apneachildrenamplitude of low-frequency fluctuation fractionalregional homogeneityfunctional magnetic resonance imagingresting stateNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Neuroscience, Vol 15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	obstructive sleep apnea children amplitude of low-frequency fluctuation fractional regional homogeneity functional magnetic resonance imaging resting state Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	obstructive sleep apnea children amplitude of low-frequency fluctuation fractional regional homogeneity functional magnetic resonance imaging resting state Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Jie Bai Hongwei Wen Hongwei Wen Jun Tai Yun Peng Hongbin Li Lin Mei Tingting Ji Xiaodan Li Yanhua Li Xin Ni Yue Liu Altered Spontaneous Brain Activity Related to Neurologic and Sleep Dysfunction in Children With Obstructive Sleep Apnea Syndrome
description	Childhood obstructive sleep apnea (OSA) is a common chronic sleep-related breathing disorder in children, which leads to growth retardation, neurocognitive impairments, and serious complications. Considering the previous studies about brain structural abnormalities in OSA, in the present study, we aimed to explore the altered spontaneous brain activity among OSA patients, using amplitude of low-frequency fluctuation (ALFF), fractional ALFF (fALFF), and regional homogeneity (ReHo) methods based on resting-state functional magnetic resonance imaging (MRI). Thirty-one untreated OSA children and 33 age-and gender-matched healthy children (HC) were included in this study. Compared with controls, the OSA group showed significant lower ALFF in the right lingual gyrus, decreased fALFF in the left middle frontal gyrus (MFG), but increased fALFF in the left precuneus. Decreased ReHo was found in the left inferior frontal gyrus (orbital part) and left middle frontal gyrus. Notably, the mean fALFF value of left MFG was not only significantly related to multiple sleep parameters but also demonstrated the best performance in ROC curve analysis. These findings revealed OSA children were associated with dysfunctions in the default mode network, the frontal lobe, and the lingual gyrus, which may implicate the underlying neurophysiological mechanisms of intrinsic brain activity. The correlation between the altered spontaneous neuronal activity and the clinical index provides early useful diagnostic biomarkers for OSA children as well.
format	article
author	Jie Bai Hongwei Wen Hongwei Wen Jun Tai Yun Peng Hongbin Li Lin Mei Tingting Ji Xiaodan Li Yanhua Li Xin Ni Yue Liu
author_facet	Jie Bai Hongwei Wen Hongwei Wen Jun Tai Yun Peng Hongbin Li Lin Mei Tingting Ji Xiaodan Li Yanhua Li Xin Ni Yue Liu
author_sort	Jie Bai
title	Altered Spontaneous Brain Activity Related to Neurologic and Sleep Dysfunction in Children With Obstructive Sleep Apnea Syndrome
title_short	Altered Spontaneous Brain Activity Related to Neurologic and Sleep Dysfunction in Children With Obstructive Sleep Apnea Syndrome
title_full	Altered Spontaneous Brain Activity Related to Neurologic and Sleep Dysfunction in Children With Obstructive Sleep Apnea Syndrome
title_fullStr	Altered Spontaneous Brain Activity Related to Neurologic and Sleep Dysfunction in Children With Obstructive Sleep Apnea Syndrome
title_full_unstemmed	Altered Spontaneous Brain Activity Related to Neurologic and Sleep Dysfunction in Children With Obstructive Sleep Apnea Syndrome
title_sort	altered spontaneous brain activity related to neurologic and sleep dysfunction in children with obstructive sleep apnea syndrome
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/d73b54b804de4fcc8578d7518ca22ec2
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Altered Spontaneous Brain Activity Related to Neurologic and Sleep Dysfunction in Children With Obstructive Sleep Apnea Syndrome

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