Acute and subchronic dermal toxicity of nanosilver in guinea pig

M Korani1, SM Rezayat1,2,4,&nbsp;K Gilani3, S Arbabi Bidgoli4, S Adeli11Department of Pharmacology, Faculty of Medicine, Tehran University of Medical Sciences; 2Department of Nanotechnology, Faculty of Advanced Sciences and Technology in Medicine, Tehran University of Medical Sciences;&a...

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Autores principales:	Arbabi Bidgoli S, Rezayat SM,&nbsp;Gilani K, Adeli S, Korani M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/d73d21fa4fd54be7803fbdd79abb67c3
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spelling	oai:doaj.org-article:d73d21fa4fd54be7803fbdd79abb67c32021-12-02T08:07:45ZAcute and subchronic dermal toxicity of nanosilver in guinea pig1176-91141178-2013https://doaj.org/article/d73d21fa4fd54be7803fbdd79abb67c32011-04-01T00:00:00Zhttp://www.dovepress.com/acute-and-subchronic-dermal-toxicity-of-nanosilver-in-guinea-pig-a7241https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013M Korani1, SM Rezayat1,2,4,&nbsp;K Gilani3, S Arbabi Bidgoli4, S Adeli11Department of Pharmacology, Faculty of Medicine, Tehran University of Medical Sciences; 2Department of Nanotechnology, Faculty of Advanced Sciences and Technology in Medicine, Tehran University of Medical Sciences;&nbsp;3Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences; 4Department of Toxicology &amp; Pharmacology, Faculty of Pharmacy, Pharmaceutical Sciences Branch, Islamic Azad University (IAUPS), Tehran, IranAbstract: Silver has been used as an antimicrobial agent for a long time in different forms, but silver nanoparticles (nanosilver) have recently been recognized as potent antimicrobial agents. Although nanosilver is finding diverse medical applications such as silver-based dressings and silver-coated medical devices, its dermal and systemic toxicity via dermal use has not yet been identified. In this study, we analyzed the potential toxicity of colloidal nanosilver in acute and subchronic guinea pigs. Before toxicity assessments, the size of colloidal nanosilver was recorded in sizes &lt;100 nm by X-ray diffraction and transmission electron microscopy. For toxicological assessments, male guinea pigs weighing 350 to 400 g were exposed to two different concentrations of nanosilver (1000 and 10,000 &micro;g/mL) in an acute study and three concentrations of nanosilver (100, 1000, and 10,000 &micro;g/mL) in a subchronic study. Toxic responses were assessed by clinical and histopathologic parameters. In all experimental animals the sites of exposure were scored for any type of dermal toxicity and compared with negative control and positive control groups. In autopsy studies during the acute test, no significant changes in organ weight or major macroscopic changes were detected, but dose-dependent histopathologic abnormalities were seen in skin, liver, and spleen of all test groups. In addition, experimental animals subjected to subchronic tests showed greater tissue abnormalities than the subjects of acute tests. It seems that colloidal nanosilver has the potential to provide target organ toxicities in a dose- and time-dependent manner.Keywords: nanosilver, acute dermal toxicity, subchronic dermal toxicityArbabi Bidgoli SRezayat SM,&nbsp;Gilani KAdeli SKorani MDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2011, Iss default, Pp 855-862 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Arbabi Bidgoli S Rezayat SM,&nbsp;Gilani K Adeli S Korani M Acute and subchronic dermal toxicity of nanosilver in guinea pig
description	M Korani1, SM Rezayat1,2,4,&nbsp;K Gilani3, S Arbabi Bidgoli4, S Adeli11Department of Pharmacology, Faculty of Medicine, Tehran University of Medical Sciences; 2Department of Nanotechnology, Faculty of Advanced Sciences and Technology in Medicine, Tehran University of Medical Sciences;&nbsp;3Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences; 4Department of Toxicology &amp; Pharmacology, Faculty of Pharmacy, Pharmaceutical Sciences Branch, Islamic Azad University (IAUPS), Tehran, IranAbstract: Silver has been used as an antimicrobial agent for a long time in different forms, but silver nanoparticles (nanosilver) have recently been recognized as potent antimicrobial agents. Although nanosilver is finding diverse medical applications such as silver-based dressings and silver-coated medical devices, its dermal and systemic toxicity via dermal use has not yet been identified. In this study, we analyzed the potential toxicity of colloidal nanosilver in acute and subchronic guinea pigs. Before toxicity assessments, the size of colloidal nanosilver was recorded in sizes &lt;100 nm by X-ray diffraction and transmission electron microscopy. For toxicological assessments, male guinea pigs weighing 350 to 400 g were exposed to two different concentrations of nanosilver (1000 and 10,000 &micro;g/mL) in an acute study and three concentrations of nanosilver (100, 1000, and 10,000 &micro;g/mL) in a subchronic study. Toxic responses were assessed by clinical and histopathologic parameters. In all experimental animals the sites of exposure were scored for any type of dermal toxicity and compared with negative control and positive control groups. In autopsy studies during the acute test, no significant changes in organ weight or major macroscopic changes were detected, but dose-dependent histopathologic abnormalities were seen in skin, liver, and spleen of all test groups. In addition, experimental animals subjected to subchronic tests showed greater tissue abnormalities than the subjects of acute tests. It seems that colloidal nanosilver has the potential to provide target organ toxicities in a dose- and time-dependent manner.Keywords: nanosilver, acute dermal toxicity, subchronic dermal toxicity
format	article
author	Arbabi Bidgoli S Rezayat SM,&nbsp;Gilani K Adeli S Korani M
author_facet	Arbabi Bidgoli S Rezayat SM,&nbsp;Gilani K Adeli S Korani M
author_sort	Arbabi Bidgoli S
title	Acute and subchronic dermal toxicity of nanosilver in guinea pig
title_short	Acute and subchronic dermal toxicity of nanosilver in guinea pig
title_full	Acute and subchronic dermal toxicity of nanosilver in guinea pig
title_fullStr	Acute and subchronic dermal toxicity of nanosilver in guinea pig
title_full_unstemmed	Acute and subchronic dermal toxicity of nanosilver in guinea pig
title_sort	acute and subchronic dermal toxicity of nanosilver in guinea pig
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/d73d21fa4fd54be7803fbdd79abb67c3
work_keys_str_mv	AT arbabibidgolis acuteandsubchronicdermaltoxicityofnanosilveringuineapig AT rezayatsmampnbspgilanik acuteandsubchronicdermaltoxicityofnanosilveringuineapig AT adelis acuteandsubchronicdermaltoxicityofnanosilveringuineapig AT koranim acuteandsubchronicdermaltoxicityofnanosilveringuineapig
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Acute and subchronic dermal toxicity of nanosilver in guinea pig

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