Association of lung function with functional limitation in older adults: A cross-sectional study.

<h4>Introduction</h4>Impaired lung function is independently associated with higher rates of disability, however, few studies have examined the association between lung function and functional limitation. This study aimed to assess this association and dose-response relationship in older...

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Autores principales:	Yu Gao, Liang Shen, Runqing Zhan, Xiaoxu Wang, Huanhuan Chen, Xiaoli Shen
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d73e7d27db524ffdb1fca8c2ce29b68f
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spelling	oai:doaj.org-article:d73e7d27db524ffdb1fca8c2ce29b68f2021-12-02T20:09:51ZAssociation of lung function with functional limitation in older adults: A cross-sectional study.1932-620310.1371/journal.pone.0253606https://doaj.org/article/d73e7d27db524ffdb1fca8c2ce29b68f2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0253606https://doaj.org/toc/1932-6203<h4>Introduction</h4>Impaired lung function is independently associated with higher rates of disability, however, few studies have examined the association between lung function and functional limitation. This study aimed to assess this association and dose-response relationship in older adults.<h4>Methods</h4>Data from the National Health and Nutrition Examination Survey (2007-2012) was used as a cross-sectional study. Lung function was determined by Forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC). Functional limitation in older adults was identified by six self-reported questions on physical function. 3070 adults aged 60 and over were enrolled in our study. Logistic regression models and restricted cubic spline models were applied to examine the association between lung function and the risk of functional limitation.<h4>Results</h4>FEV1 and FVC were inversely associated with the risk of functional limitation. In the full adjusted model, compared with the lowest tertile of FEV1, the odds ratios (95% confidence intervals) of functional limitation for tertile 2 and tertile 3 were 0.5422 (0.3848-0.7639) and 0.4403 (0.2685-0.7220), and the odds ratios (95% confidence intervals) of functional limitation for tertile 2 and tertile 3 of FVC were 0.5243 (0.3503-0.7848) and 0.3726 (0.2072-0.6698). Furthermore, an inverse association persisted after stratified analysis by gender and sensitivity analysis. Dose-response analyses showed that the odds of functional limitation declined with increase in FEV1 and FVC in a nonlinear manner.<h4>Conclusions</h4>Lung function was inversely associated with functional limitation among older adults.Yu GaoLiang ShenRunqing ZhanXiaoxu WangHuanhuan ChenXiaoli ShenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 6, p e0253606 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yu Gao Liang Shen Runqing Zhan Xiaoxu Wang Huanhuan Chen Xiaoli Shen Association of lung function with functional limitation in older adults: A cross-sectional study.
description	<h4>Introduction</h4>Impaired lung function is independently associated with higher rates of disability, however, few studies have examined the association between lung function and functional limitation. This study aimed to assess this association and dose-response relationship in older adults.<h4>Methods</h4>Data from the National Health and Nutrition Examination Survey (2007-2012) was used as a cross-sectional study. Lung function was determined by Forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC). Functional limitation in older adults was identified by six self-reported questions on physical function. 3070 adults aged 60 and over were enrolled in our study. Logistic regression models and restricted cubic spline models were applied to examine the association between lung function and the risk of functional limitation.<h4>Results</h4>FEV1 and FVC were inversely associated with the risk of functional limitation. In the full adjusted model, compared with the lowest tertile of FEV1, the odds ratios (95% confidence intervals) of functional limitation for tertile 2 and tertile 3 were 0.5422 (0.3848-0.7639) and 0.4403 (0.2685-0.7220), and the odds ratios (95% confidence intervals) of functional limitation for tertile 2 and tertile 3 of FVC were 0.5243 (0.3503-0.7848) and 0.3726 (0.2072-0.6698). Furthermore, an inverse association persisted after stratified analysis by gender and sensitivity analysis. Dose-response analyses showed that the odds of functional limitation declined with increase in FEV1 and FVC in a nonlinear manner.<h4>Conclusions</h4>Lung function was inversely associated with functional limitation among older adults.
format	article
author	Yu Gao Liang Shen Runqing Zhan Xiaoxu Wang Huanhuan Chen Xiaoli Shen
author_facet	Yu Gao Liang Shen Runqing Zhan Xiaoxu Wang Huanhuan Chen Xiaoli Shen
author_sort	Yu Gao
title	Association of lung function with functional limitation in older adults: A cross-sectional study.
title_short	Association of lung function with functional limitation in older adults: A cross-sectional study.
title_full	Association of lung function with functional limitation in older adults: A cross-sectional study.
title_fullStr	Association of lung function with functional limitation in older adults: A cross-sectional study.
title_full_unstemmed	Association of lung function with functional limitation in older adults: A cross-sectional study.
title_sort	association of lung function with functional limitation in older adults: a cross-sectional study.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/d73e7d27db524ffdb1fca8c2ce29b68f
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Association of lung function with functional limitation in older adults: A cross-sectional study.

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