Clinical and prognostic features of MMP-2 and VEGF in AEG patients

Adenocarcinoma of the esophagogastric junction (AEG) has been increased in recent years and has become a worldwide problem that seriously affects human health. The purpose of the study is to investigate the clinical and prognostic characteristics of the matrix metalloproteinase-2 (MMP-2) and vascula...

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Autores principales:	Zheng Qing-Kang, Yin Qing, Zhang Nan, Sun Zhi-Gang
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	adenocarcinoma of the esophagogastric junction mmp-2 vegf immunohistochemistry Medicine R
Acceso en línea:	https://doaj.org/article/d73ef4c02ff24df18da69dbcb12a731e
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spelling	oai:doaj.org-article:d73ef4c02ff24df18da69dbcb12a731e2021-12-05T14:10:54ZClinical and prognostic features of MMP-2 and VEGF in AEG patients2391-546310.1515/med-2021-0252https://doaj.org/article/d73ef4c02ff24df18da69dbcb12a731e2021-05-01T00:00:00Zhttps://doi.org/10.1515/med-2021-0252https://doaj.org/toc/2391-5463Adenocarcinoma of the esophagogastric junction (AEG) has been increased in recent years and has become a worldwide problem that seriously affects human health. The purpose of the study is to investigate the clinical and prognostic characteristics of the matrix metalloproteinase-2 (MMP-2) and vascular endothelial growth factor (VEGF) expression in AEG patients. A total of 69 patients were enrolled in this study. The result showed that the high expression of MMP-2 was significantly associated with tumor differentiation (P < 0.05) and depth of invasion (pT, P < 0.05). The high expression of VEGF was significantly associated with pT (P < 0.05) and lymph node metastasis (pN, P < 0.05). There was a positive correlation between MMP-2 and VEGF expression (P < 0.01). The 5-year survival rate for the 69 AEG patients was 40.6% and it was significantly associated with tumor differentiation (P < 0.05), pN (P < 0.01), pTNM stage (P < 0.01), MMP-2 expression (P < 0.05), and VEGF expression (P < 0.05). Cox multivariate regression demonstrated that tumor differentiation and pN were independent factors for the 5-year survival rate. Our study showed that MMP-2 and VEGF could work synergistically in AEG development.Zheng Qing-KangYin QingZhang NanSun Zhi-GangDe Gruyterarticleadenocarcinoma of the esophagogastric junctionmmp-2vegfimmunohistochemistryMedicineRENOpen Medicine, Vol 16, Iss 1, Pp 786-794 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	adenocarcinoma of the esophagogastric junction mmp-2 vegf immunohistochemistry Medicine R
spellingShingle	adenocarcinoma of the esophagogastric junction mmp-2 vegf immunohistochemistry Medicine R Zheng Qing-Kang Yin Qing Zhang Nan Sun Zhi-Gang Clinical and prognostic features of MMP-2 and VEGF in AEG patients
description	Adenocarcinoma of the esophagogastric junction (AEG) has been increased in recent years and has become a worldwide problem that seriously affects human health. The purpose of the study is to investigate the clinical and prognostic characteristics of the matrix metalloproteinase-2 (MMP-2) and vascular endothelial growth factor (VEGF) expression in AEG patients. A total of 69 patients were enrolled in this study. The result showed that the high expression of MMP-2 was significantly associated with tumor differentiation (P < 0.05) and depth of invasion (pT, P < 0.05). The high expression of VEGF was significantly associated with pT (P < 0.05) and lymph node metastasis (pN, P < 0.05). There was a positive correlation between MMP-2 and VEGF expression (P < 0.01). The 5-year survival rate for the 69 AEG patients was 40.6% and it was significantly associated with tumor differentiation (P < 0.05), pN (P < 0.01), pTNM stage (P < 0.01), MMP-2 expression (P < 0.05), and VEGF expression (P < 0.05). Cox multivariate regression demonstrated that tumor differentiation and pN were independent factors for the 5-year survival rate. Our study showed that MMP-2 and VEGF could work synergistically in AEG development.
format	article
author	Zheng Qing-Kang Yin Qing Zhang Nan Sun Zhi-Gang
author_facet	Zheng Qing-Kang Yin Qing Zhang Nan Sun Zhi-Gang
author_sort	Zheng Qing-Kang
title	Clinical and prognostic features of MMP-2 and VEGF in AEG patients
title_short	Clinical and prognostic features of MMP-2 and VEGF in AEG patients
title_full	Clinical and prognostic features of MMP-2 and VEGF in AEG patients
title_fullStr	Clinical and prognostic features of MMP-2 and VEGF in AEG patients
title_full_unstemmed	Clinical and prognostic features of MMP-2 and VEGF in AEG patients
title_sort	clinical and prognostic features of mmp-2 and vegf in aeg patients
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/d73ef4c02ff24df18da69dbcb12a731e
work_keys_str_mv	AT zhengqingkang clinicalandprognosticfeaturesofmmp2andvegfinaegpatients AT yinqing clinicalandprognosticfeaturesofmmp2andvegfinaegpatients AT zhangnan clinicalandprognosticfeaturesofmmp2andvegfinaegpatients AT sunzhigang clinicalandprognosticfeaturesofmmp2andvegfinaegpatients
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Clinical and prognostic features of MMP-2 and VEGF in AEG patients

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