Direct tissue-sensing reprograms TLR4+ Tfh-like cells inflammatory profile in the joints of rheumatoid arthritis patients

Direct tissue-sensing reprograms TLR4+ Tfh-like cells inflammatory profile in the joints of rheumatoid arthritis patients

In order to identify how the synovial microenvironment impinges on CD4+ T cells pathogenic functions in Rheumatoid Arthritis (RA), Amaral-Silva examined RA patient blood and synovial fluif and identified the presence of a TLR4+ follicular helper T (Tfh) cell-like population. They provided mechanisti...

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Auteurs principaux: Daniela Amaral-Silva, Rute Gonçalves, Rita C. Torrão, Rita Torres, Sandra Falcão, Maria João Gonçalves, Maria Paula Araújo, Maria José Martins, Carina Lopes, Agna Neto, José Marona, Tiago Costa, Walter Castelão, Ana Bento Silva, Inês Silva, Maria Helena Lourenço, Margarida Mateus, Nuno Pina Gonçalves, Santiago Manica, Manuela Costa, Fernando M. Pimentel-Santos, Ana Filipa Mourão, Jaime C. Branco, Helena Soares
Format: article
Langue:EN
Publié: Nature Portfolio 2021
Sujets:
Biology (General)
QH301-705.5
Accès en ligne:https://doaj.org/article/d73f6ecb04594d11b6f47f71dd2151e3
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Résumé:In order to identify how the synovial microenvironment impinges on CD4+ T cells pathogenic functions in Rheumatoid Arthritis (RA), Amaral-Silva examined RA patient blood and synovial fluif and identified the presence of a TLR4+ follicular helper T (Tfh) cell-like population. They provided mechanistic insight into how TLR4+ T cells uniquely reconcile an ability to promote systemic antibody production with a local synovial driven-tissue damage program.

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