Direct tissue-sensing reprograms TLR4+ Tfh-like cells inflammatory profile in the joints of rheumatoid arthritis patients
In order to identify how the synovial microenvironment impinges on CD4+ T cells pathogenic functions in Rheumatoid Arthritis (RA), Amaral-Silva examined RA patient blood and synovial fluif and identified the presence of a TLR4+ follicular helper T (Tfh) cell-like population. They provided mechanisti...
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Nature Portfolio
2021
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oai:doaj.org-article:d73f6ecb04594d11b6f47f71dd2151e32021-12-02T19:17:04ZDirect tissue-sensing reprograms TLR4+ Tfh-like cells inflammatory profile in the joints of rheumatoid arthritis patients10.1038/s42003-021-02659-02399-3642https://doaj.org/article/d73f6ecb04594d11b6f47f71dd2151e32021-09-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02659-0https://doaj.org/toc/2399-3642In order to identify how the synovial microenvironment impinges on CD4+ T cells pathogenic functions in Rheumatoid Arthritis (RA), Amaral-Silva examined RA patient blood and synovial fluif and identified the presence of a TLR4+ follicular helper T (Tfh) cell-like population. They provided mechanistic insight into how TLR4+ T cells uniquely reconcile an ability to promote systemic antibody production with a local synovial driven-tissue damage program.Daniela Amaral-SilvaRute GonçalvesRita C. TorrãoRita TorresSandra FalcãoMaria João GonçalvesMaria Paula AraújoMaria José MartinsCarina LopesAgna NetoJosé MaronaTiago CostaWalter CastelãoAna Bento SilvaInês SilvaMaria Helena LourençoMargarida MateusNuno Pina GonçalvesSantiago ManicaManuela CostaFernando M. Pimentel-SantosAna Filipa MourãoJaime C. BrancoHelena SoaresNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-16 (2021) |
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Biology (General) QH301-705.5 |
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Biology (General) QH301-705.5 Daniela Amaral-Silva Rute Gonçalves Rita C. Torrão Rita Torres Sandra Falcão Maria João Gonçalves Maria Paula Araújo Maria José Martins Carina Lopes Agna Neto José Marona Tiago Costa Walter Castelão Ana Bento Silva Inês Silva Maria Helena Lourenço Margarida Mateus Nuno Pina Gonçalves Santiago Manica Manuela Costa Fernando M. Pimentel-Santos Ana Filipa Mourão Jaime C. Branco Helena Soares Direct tissue-sensing reprograms TLR4+ Tfh-like cells inflammatory profile in the joints of rheumatoid arthritis patients |
| description |
In order to identify how the synovial microenvironment impinges on CD4+ T cells pathogenic functions in Rheumatoid Arthritis (RA), Amaral-Silva examined RA patient blood and synovial fluif and identified the presence of a TLR4+ follicular helper T (Tfh) cell-like population. They provided mechanistic insight into how TLR4+ T cells uniquely reconcile an ability to promote systemic antibody production with a local synovial driven-tissue damage program. |
| format |
article |
| author |
Daniela Amaral-Silva Rute Gonçalves Rita C. Torrão Rita Torres Sandra Falcão Maria João Gonçalves Maria Paula Araújo Maria José Martins Carina Lopes Agna Neto José Marona Tiago Costa Walter Castelão Ana Bento Silva Inês Silva Maria Helena Lourenço Margarida Mateus Nuno Pina Gonçalves Santiago Manica Manuela Costa Fernando M. Pimentel-Santos Ana Filipa Mourão Jaime C. Branco Helena Soares |
| author_facet |
Daniela Amaral-Silva Rute Gonçalves Rita C. Torrão Rita Torres Sandra Falcão Maria João Gonçalves Maria Paula Araújo Maria José Martins Carina Lopes Agna Neto José Marona Tiago Costa Walter Castelão Ana Bento Silva Inês Silva Maria Helena Lourenço Margarida Mateus Nuno Pina Gonçalves Santiago Manica Manuela Costa Fernando M. Pimentel-Santos Ana Filipa Mourão Jaime C. Branco Helena Soares |
| author_sort |
Daniela Amaral-Silva |
| title |
Direct tissue-sensing reprograms TLR4+ Tfh-like cells inflammatory profile in the joints of rheumatoid arthritis patients |
| title_short |
Direct tissue-sensing reprograms TLR4+ Tfh-like cells inflammatory profile in the joints of rheumatoid arthritis patients |
| title_full |
Direct tissue-sensing reprograms TLR4+ Tfh-like cells inflammatory profile in the joints of rheumatoid arthritis patients |
| title_fullStr |
Direct tissue-sensing reprograms TLR4+ Tfh-like cells inflammatory profile in the joints of rheumatoid arthritis patients |
| title_full_unstemmed |
Direct tissue-sensing reprograms TLR4+ Tfh-like cells inflammatory profile in the joints of rheumatoid arthritis patients |
| title_sort |
direct tissue-sensing reprograms tlr4+ tfh-like cells inflammatory profile in the joints of rheumatoid arthritis patients |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/d73f6ecb04594d11b6f47f71dd2151e3 |
| work_keys_str_mv |
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