Baseline CD4 cell counts of newly diagnosed HIV cases in China: 2006-2012.

<h4>Background</h4>Late diagnosis of HIV infection is common. We aim to assess the proportion of newly diagnosed HIV cases receiving timely baseline CD4 count testing and the associated factors in China.<h4>Methods</h4>Data were extracted from the Chinese HIV/AIDS Comprehensi...

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Autores principales:	Houlin Tang, Yurong Mao, Cynthia X Shi, Jing Han, Liyan Wang, Juan Xu, Qianqian Qin, Roger Detels, Zunyou Wu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d73f89392c584b52be7dae406b8c5f9e
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spelling	oai:doaj.org-article:d73f89392c584b52be7dae406b8c5f9e2021-11-18T08:16:55ZBaseline CD4 cell counts of newly diagnosed HIV cases in China: 2006-2012.1932-620310.1371/journal.pone.0096098https://doaj.org/article/d73f89392c584b52be7dae406b8c5f9e2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24901790/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Late diagnosis of HIV infection is common. We aim to assess the proportion of newly diagnosed HIV cases receiving timely baseline CD4 count testing and the associated factors in China.<h4>Methods</h4>Data were extracted from the Chinese HIV/AIDS Comprehensive Response Information Management System. Adult patients over 15 years old who had been newly diagnosed with HIV infection in China between 2006 and 2012 were identified. The study cohort comprised individuals who had a measured baseline CD4 count.<h4>Results</h4>Among 388,496 newly identified HIV cases, the median baseline CD4 count was 294 cells/µl (IQR: 130-454), and over half (N = 130,442, 58.8%) were less than 350 cells/µl. The median baseline CD4 count increased from 221 (IQR: 63-410) in 2006 to 314 (IQR: 159-460) in 2012. A slight majority of patients (N = 221,980, 57.1%) received baseline CD4 count testing within 6 months of diagnosis. The proportion of individuals who received timely baseline CD4 count testing increased significantly from 20.0% in 2006 to 76.9% in 2012. Factors associated with failing to receiving timely CD4 count testing were: being male (OR: 1.17, 95% CI: 1.15-1.19), age 55 years or older (OR:1.03, 95% CI: 1.00-1.06), educational attainment of primary school education or below (OR: 1.30, 95% CI: 1.28-1.32), infection with HIV through injection drug use (OR: 2.07, 95% CI: 2.02-2.12) or sexual contact and injection drug use (OR: 1.87, 95% CI: 1.76-1.99), diagnosis in a hospital (OR: 1.91, 95% CI: 1.88-1.95) or in a detention center (OR: 1.75, 95% CI: 1.70-1.80), and employment as a migrant worker (OR:1.55, 95% CI:1.53-1.58).<h4>Conclusion</h4>The proportion of newly identified HIV patients receiving timely baseline CD4 testing has increased significantly in China from 2006-2012. Continued effort is needed for further promotion of early HIV diagnosis and timely baseline CD4 cell count testing.Houlin TangYurong MaoCynthia X ShiJing HanLiyan WangJuan XuQianqian QinRoger DetelsZunyou WuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 6, p e96098 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Houlin Tang Yurong Mao Cynthia X Shi Jing Han Liyan Wang Juan Xu Qianqian Qin Roger Detels Zunyou Wu Baseline CD4 cell counts of newly diagnosed HIV cases in China: 2006-2012.
description	<h4>Background</h4>Late diagnosis of HIV infection is common. We aim to assess the proportion of newly diagnosed HIV cases receiving timely baseline CD4 count testing and the associated factors in China.<h4>Methods</h4>Data were extracted from the Chinese HIV/AIDS Comprehensive Response Information Management System. Adult patients over 15 years old who had been newly diagnosed with HIV infection in China between 2006 and 2012 were identified. The study cohort comprised individuals who had a measured baseline CD4 count.<h4>Results</h4>Among 388,496 newly identified HIV cases, the median baseline CD4 count was 294 cells/µl (IQR: 130-454), and over half (N = 130,442, 58.8%) were less than 350 cells/µl. The median baseline CD4 count increased from 221 (IQR: 63-410) in 2006 to 314 (IQR: 159-460) in 2012. A slight majority of patients (N = 221,980, 57.1%) received baseline CD4 count testing within 6 months of diagnosis. The proportion of individuals who received timely baseline CD4 count testing increased significantly from 20.0% in 2006 to 76.9% in 2012. Factors associated with failing to receiving timely CD4 count testing were: being male (OR: 1.17, 95% CI: 1.15-1.19), age 55 years or older (OR:1.03, 95% CI: 1.00-1.06), educational attainment of primary school education or below (OR: 1.30, 95% CI: 1.28-1.32), infection with HIV through injection drug use (OR: 2.07, 95% CI: 2.02-2.12) or sexual contact and injection drug use (OR: 1.87, 95% CI: 1.76-1.99), diagnosis in a hospital (OR: 1.91, 95% CI: 1.88-1.95) or in a detention center (OR: 1.75, 95% CI: 1.70-1.80), and employment as a migrant worker (OR:1.55, 95% CI:1.53-1.58).<h4>Conclusion</h4>The proportion of newly identified HIV patients receiving timely baseline CD4 testing has increased significantly in China from 2006-2012. Continued effort is needed for further promotion of early HIV diagnosis and timely baseline CD4 cell count testing.
format	article
author	Houlin Tang Yurong Mao Cynthia X Shi Jing Han Liyan Wang Juan Xu Qianqian Qin Roger Detels Zunyou Wu
author_facet	Houlin Tang Yurong Mao Cynthia X Shi Jing Han Liyan Wang Juan Xu Qianqian Qin Roger Detels Zunyou Wu
author_sort	Houlin Tang
title	Baseline CD4 cell counts of newly diagnosed HIV cases in China: 2006-2012.
title_short	Baseline CD4 cell counts of newly diagnosed HIV cases in China: 2006-2012.
title_full	Baseline CD4 cell counts of newly diagnosed HIV cases in China: 2006-2012.
title_fullStr	Baseline CD4 cell counts of newly diagnosed HIV cases in China: 2006-2012.
title_full_unstemmed	Baseline CD4 cell counts of newly diagnosed HIV cases in China: 2006-2012.
title_sort	baseline cd4 cell counts of newly diagnosed hiv cases in china: 2006-2012.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/d73f89392c584b52be7dae406b8c5f9e
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Baseline CD4 cell counts of newly diagnosed HIV cases in China: 2006-2012.

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