Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials
Hydroxychloroquine and chloroquine have been investigated as a potential treatment for Covid-19 in several clinical trials. Here the authors report a meta-analysis of published and unpublished trials, and show that treatment with hydroxychloroquine for patients with Covid-19 was associated with incr...
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2021
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oai:doaj.org-article:d742d7263e7f4393b9fbfd3d3114ad612021-12-02T15:51:06ZMortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials10.1038/s41467-021-22446-z2041-1723https://doaj.org/article/d742d7263e7f4393b9fbfd3d3114ad612021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22446-zhttps://doaj.org/toc/2041-1723Hydroxychloroquine and chloroquine have been investigated as a potential treatment for Covid-19 in several clinical trials. Here the authors report a meta-analysis of published and unpublished trials, and show that treatment with hydroxychloroquine for patients with Covid-19 was associated with increased mortality, and there was no benefit from chloroquine.Cathrine AxforsAndreas M. SchmittPerrine JaniaudJanneke van’t HooftSherief Abd-ElsalamEhab F. AbdoBenjamin S. AbellaJaved AkramRavi K. AmaravadiDerek C. AngusYaseen M. ArabiShehnoor AzharLindsey R. BadenArthur W. BakerLeila BelkhirThomas BenfieldMarvin A. H. BerrevoetsCheng-Pin ChenTsung-Chia ChenShu-Hsing ChengChien-Yu ChengWei-Sheng ChungYehuda Z. CohenLisa N. CowanOlav DalgardFernando F. de Almeida e ValMarcus V. G. de LacerdaGisely C. de MeloLennie DerdeVincent DubeeAnissa ElfakirAnthony C. GordonCarmen M. Hernandez-CardenasThomas HillsAndy I. M. HoepelmanYi-Wen HuangBruno IgauRonghua JinFelipe Jurado-CamachoKhalid S. KhanPeter G. KremsnerBenno KreuelsCheng-Yu KuoThuy LeYi-Chun LinWu-Pu LinTse-Hung LinMagnus Nakrem LyngbakkenColin McArthurBryan J. McVerryPatricia Meza-MenesesWuelton M. MonteiroSusan C. MorpethAhmad MouradMark J. MulliganSrinivas MurthySusanna NaggieShanti NarayanasamyAlistair NicholLewis A. NovackSean M. O’BrienNwora Lance OkekeLéna PerezRogelio Perez-PadillaLaurent PerrinArantxa Remigio-LunaNorma E. Rivera-MartinezFrank W. RockholdSebastian Rodriguez-LlamazaresRobert RolfeRossana RosaHelge RøsjøVanderson S. SampaioTodd B. SetoMuhammad ShehzadShaimaa SolimanJason E. StoutIreri Thirion-RomeroAndrea B. TroxelTing-Yu TsengNicholas A. TurnerRobert J. UlrichStephen R. WalshSteve A. WebbJesper M. WeehuizenMaria VelinovaHon-Lai WongRebekah WrennFernando G. ZampieriWu ZhongDavid MoherSteven N. GoodmanJohn P. A. IoannidisLars G. HemkensNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021) |
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DOAJ |
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EN |
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Science Q |
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Science Q Cathrine Axfors Andreas M. Schmitt Perrine Janiaud Janneke van’t Hooft Sherief Abd-Elsalam Ehab F. Abdo Benjamin S. Abella Javed Akram Ravi K. Amaravadi Derek C. Angus Yaseen M. Arabi Shehnoor Azhar Lindsey R. Baden Arthur W. Baker Leila Belkhir Thomas Benfield Marvin A. H. Berrevoets Cheng-Pin Chen Tsung-Chia Chen Shu-Hsing Cheng Chien-Yu Cheng Wei-Sheng Chung Yehuda Z. Cohen Lisa N. Cowan Olav Dalgard Fernando F. de Almeida e Val Marcus V. G. de Lacerda Gisely C. de Melo Lennie Derde Vincent Dubee Anissa Elfakir Anthony C. Gordon Carmen M. Hernandez-Cardenas Thomas Hills Andy I. M. Hoepelman Yi-Wen Huang Bruno Igau Ronghua Jin Felipe Jurado-Camacho Khalid S. Khan Peter G. Kremsner Benno Kreuels Cheng-Yu Kuo Thuy Le Yi-Chun Lin Wu-Pu Lin Tse-Hung Lin Magnus Nakrem Lyngbakken Colin McArthur Bryan J. McVerry Patricia Meza-Meneses Wuelton M. Monteiro Susan C. Morpeth Ahmad Mourad Mark J. Mulligan Srinivas Murthy Susanna Naggie Shanti Narayanasamy Alistair Nichol Lewis A. Novack Sean M. O’Brien Nwora Lance Okeke Léna Perez Rogelio Perez-Padilla Laurent Perrin Arantxa Remigio-Luna Norma E. Rivera-Martinez Frank W. Rockhold Sebastian Rodriguez-Llamazares Robert Rolfe Rossana Rosa Helge Røsjø Vanderson S. Sampaio Todd B. Seto Muhammad Shehzad Shaimaa Soliman Jason E. Stout Ireri Thirion-Romero Andrea B. Troxel Ting-Yu Tseng Nicholas A. Turner Robert J. Ulrich Stephen R. Walsh Steve A. Webb Jesper M. Weehuizen Maria Velinova Hon-Lai Wong Rebekah Wrenn Fernando G. Zampieri Wu Zhong David Moher Steven N. Goodman John P. A. Ioannidis Lars G. Hemkens Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials |
| description |
Hydroxychloroquine and chloroquine have been investigated as a potential treatment for Covid-19 in several clinical trials. Here the authors report a meta-analysis of published and unpublished trials, and show that treatment with hydroxychloroquine for patients with Covid-19 was associated with increased mortality, and there was no benefit from chloroquine. |
| format |
article |
| author |
Cathrine Axfors Andreas M. Schmitt Perrine Janiaud Janneke van’t Hooft Sherief Abd-Elsalam Ehab F. Abdo Benjamin S. Abella Javed Akram Ravi K. Amaravadi Derek C. Angus Yaseen M. Arabi Shehnoor Azhar Lindsey R. Baden Arthur W. Baker Leila Belkhir Thomas Benfield Marvin A. H. Berrevoets Cheng-Pin Chen Tsung-Chia Chen Shu-Hsing Cheng Chien-Yu Cheng Wei-Sheng Chung Yehuda Z. Cohen Lisa N. Cowan Olav Dalgard Fernando F. de Almeida e Val Marcus V. G. de Lacerda Gisely C. de Melo Lennie Derde Vincent Dubee Anissa Elfakir Anthony C. Gordon Carmen M. Hernandez-Cardenas Thomas Hills Andy I. M. Hoepelman Yi-Wen Huang Bruno Igau Ronghua Jin Felipe Jurado-Camacho Khalid S. Khan Peter G. Kremsner Benno Kreuels Cheng-Yu Kuo Thuy Le Yi-Chun Lin Wu-Pu Lin Tse-Hung Lin Magnus Nakrem Lyngbakken Colin McArthur Bryan J. McVerry Patricia Meza-Meneses Wuelton M. Monteiro Susan C. Morpeth Ahmad Mourad Mark J. Mulligan Srinivas Murthy Susanna Naggie Shanti Narayanasamy Alistair Nichol Lewis A. Novack Sean M. O’Brien Nwora Lance Okeke Léna Perez Rogelio Perez-Padilla Laurent Perrin Arantxa Remigio-Luna Norma E. Rivera-Martinez Frank W. Rockhold Sebastian Rodriguez-Llamazares Robert Rolfe Rossana Rosa Helge Røsjø Vanderson S. Sampaio Todd B. Seto Muhammad Shehzad Shaimaa Soliman Jason E. Stout Ireri Thirion-Romero Andrea B. Troxel Ting-Yu Tseng Nicholas A. Turner Robert J. Ulrich Stephen R. Walsh Steve A. Webb Jesper M. Weehuizen Maria Velinova Hon-Lai Wong Rebekah Wrenn Fernando G. Zampieri Wu Zhong David Moher Steven N. Goodman John P. A. Ioannidis Lars G. Hemkens |
| author_facet |
Cathrine Axfors Andreas M. Schmitt Perrine Janiaud Janneke van’t Hooft Sherief Abd-Elsalam Ehab F. Abdo Benjamin S. Abella Javed Akram Ravi K. Amaravadi Derek C. Angus Yaseen M. Arabi Shehnoor Azhar Lindsey R. Baden Arthur W. Baker Leila Belkhir Thomas Benfield Marvin A. H. Berrevoets Cheng-Pin Chen Tsung-Chia Chen Shu-Hsing Cheng Chien-Yu Cheng Wei-Sheng Chung Yehuda Z. Cohen Lisa N. Cowan Olav Dalgard Fernando F. de Almeida e Val Marcus V. G. de Lacerda Gisely C. de Melo Lennie Derde Vincent Dubee Anissa Elfakir Anthony C. Gordon Carmen M. Hernandez-Cardenas Thomas Hills Andy I. M. Hoepelman Yi-Wen Huang Bruno Igau Ronghua Jin Felipe Jurado-Camacho Khalid S. Khan Peter G. Kremsner Benno Kreuels Cheng-Yu Kuo Thuy Le Yi-Chun Lin Wu-Pu Lin Tse-Hung Lin Magnus Nakrem Lyngbakken Colin McArthur Bryan J. McVerry Patricia Meza-Meneses Wuelton M. Monteiro Susan C. Morpeth Ahmad Mourad Mark J. Mulligan Srinivas Murthy Susanna Naggie Shanti Narayanasamy Alistair Nichol Lewis A. Novack Sean M. O’Brien Nwora Lance Okeke Léna Perez Rogelio Perez-Padilla Laurent Perrin Arantxa Remigio-Luna Norma E. Rivera-Martinez Frank W. Rockhold Sebastian Rodriguez-Llamazares Robert Rolfe Rossana Rosa Helge Røsjø Vanderson S. Sampaio Todd B. Seto Muhammad Shehzad Shaimaa Soliman Jason E. Stout Ireri Thirion-Romero Andrea B. Troxel Ting-Yu Tseng Nicholas A. Turner Robert J. Ulrich Stephen R. Walsh Steve A. Webb Jesper M. Weehuizen Maria Velinova Hon-Lai Wong Rebekah Wrenn Fernando G. Zampieri Wu Zhong David Moher Steven N. Goodman John P. A. Ioannidis Lars G. Hemkens |
| author_sort |
Cathrine Axfors |
| title |
Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials |
| title_short |
Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials |
| title_full |
Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials |
| title_fullStr |
Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials |
| title_full_unstemmed |
Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials |
| title_sort |
mortality outcomes with hydroxychloroquine and chloroquine in covid-19 from an international collaborative meta-analysis of randomized trials |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/d742d7263e7f4393b9fbfd3d3114ad61 |
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