RNF19A-mediated ubiquitination of BARD1 prevents BRCA1/BARD1-dependent homologous recombination

BRCA1 dysfunction sensitizes cancer cells to PARP inhibitors (PARPi) but the underlying mechanism is unclear. Here, the authors identify RNF19A as a determinant of PARPi sensitivity, showing that RNF19A ubiquitinates BARD1, negatively regulates the BRCA1-BARD1 complex, and inhibits homologous recomb...

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Autores principales:	Qian Zhu, Jinzhou Huang, Hongyang Huang, Huan Li, Peiqiang Yi, Jake A. Kloeber, Jian Yuan, Yuping Chen, Min Deng, Kuntian Luo, Ming Gao, Guijie Guo, Xinyi Tu, Ping Yin, Yong Zhang, Jun Su, Jiayi Chen, Zhenkun Lou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d742e4b0a47046059d6a6abb06c3fe44
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spelling	oai:doaj.org-article:d742e4b0a47046059d6a6abb06c3fe442021-11-21T12:36:23ZRNF19A-mediated ubiquitination of BARD1 prevents BRCA1/BARD1-dependent homologous recombination10.1038/s41467-021-27048-32041-1723https://doaj.org/article/d742e4b0a47046059d6a6abb06c3fe442021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27048-3https://doaj.org/toc/2041-1723BRCA1 dysfunction sensitizes cancer cells to PARP inhibitors (PARPi) but the underlying mechanism is unclear. Here, the authors identify RNF19A as a determinant of PARPi sensitivity, showing that RNF19A ubiquitinates BARD1, negatively regulates the BRCA1-BARD1 complex, and inhibits homologous recombination.Qian ZhuJinzhou HuangHongyang HuangHuan LiPeiqiang YiJake A. KloeberJian YuanYuping ChenMin DengKuntian LuoMing GaoGuijie GuoXinyi TuPing YinYong ZhangJun SuJiayi ChenZhenkun LouNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Qian Zhu Jinzhou Huang Hongyang Huang Huan Li Peiqiang Yi Jake A. Kloeber Jian Yuan Yuping Chen Min Deng Kuntian Luo Ming Gao Guijie Guo Xinyi Tu Ping Yin Yong Zhang Jun Su Jiayi Chen Zhenkun Lou RNF19A-mediated ubiquitination of BARD1 prevents BRCA1/BARD1-dependent homologous recombination
description	BRCA1 dysfunction sensitizes cancer cells to PARP inhibitors (PARPi) but the underlying mechanism is unclear. Here, the authors identify RNF19A as a determinant of PARPi sensitivity, showing that RNF19A ubiquitinates BARD1, negatively regulates the BRCA1-BARD1 complex, and inhibits homologous recombination.
format	article
author	Qian Zhu Jinzhou Huang Hongyang Huang Huan Li Peiqiang Yi Jake A. Kloeber Jian Yuan Yuping Chen Min Deng Kuntian Luo Ming Gao Guijie Guo Xinyi Tu Ping Yin Yong Zhang Jun Su Jiayi Chen Zhenkun Lou
author_facet	Qian Zhu Jinzhou Huang Hongyang Huang Huan Li Peiqiang Yi Jake A. Kloeber Jian Yuan Yuping Chen Min Deng Kuntian Luo Ming Gao Guijie Guo Xinyi Tu Ping Yin Yong Zhang Jun Su Jiayi Chen Zhenkun Lou
author_sort	Qian Zhu
title	RNF19A-mediated ubiquitination of BARD1 prevents BRCA1/BARD1-dependent homologous recombination
title_short	RNF19A-mediated ubiquitination of BARD1 prevents BRCA1/BARD1-dependent homologous recombination
title_full	RNF19A-mediated ubiquitination of BARD1 prevents BRCA1/BARD1-dependent homologous recombination
title_fullStr	RNF19A-mediated ubiquitination of BARD1 prevents BRCA1/BARD1-dependent homologous recombination
title_full_unstemmed	RNF19A-mediated ubiquitination of BARD1 prevents BRCA1/BARD1-dependent homologous recombination
title_sort	rnf19a-mediated ubiquitination of bard1 prevents brca1/bard1-dependent homologous recombination
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d742e4b0a47046059d6a6abb06c3fe44
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RNF19A-mediated ubiquitination of BARD1 prevents BRCA1/BARD1-dependent homologous recombination

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