The endoplasmic reticulum stress-autophagy pathway controls hypothalamic development and energy balance regulation in leptin-deficient neonates

Overnutrition is associated with hypothalamic ER stress and impaired leptin signaling. Here the authors show that ER stress already occurs in neonates and that treatment with the ER stress relieving drug TUDCA early in life has beneficial metabolic and neurodevelopmental effects.

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Autores principales:	Soyoung Park, Aleek Aintablian, Berengere Coupe, Sebastien G. Bouret
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d74405cf600e446290944a2d17d97396
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spelling	oai:doaj.org-article:d74405cf600e446290944a2d17d973962021-12-02T16:50:01ZThe endoplasmic reticulum stress-autophagy pathway controls hypothalamic development and energy balance regulation in leptin-deficient neonates10.1038/s41467-020-15624-y2041-1723https://doaj.org/article/d74405cf600e446290944a2d17d973962020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15624-yhttps://doaj.org/toc/2041-1723Overnutrition is associated with hypothalamic ER stress and impaired leptin signaling. Here the authors show that ER stress already occurs in neonates and that treatment with the ER stress relieving drug TUDCA early in life has beneficial metabolic and neurodevelopmental effects.Soyoung ParkAleek AintablianBerengere CoupeSebastien G. BouretNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Soyoung Park Aleek Aintablian Berengere Coupe Sebastien G. Bouret The endoplasmic reticulum stress-autophagy pathway controls hypothalamic development and energy balance regulation in leptin-deficient neonates
description	Overnutrition is associated with hypothalamic ER stress and impaired leptin signaling. Here the authors show that ER stress already occurs in neonates and that treatment with the ER stress relieving drug TUDCA early in life has beneficial metabolic and neurodevelopmental effects.
format	article
author	Soyoung Park Aleek Aintablian Berengere Coupe Sebastien G. Bouret
author_facet	Soyoung Park Aleek Aintablian Berengere Coupe Sebastien G. Bouret
author_sort	Soyoung Park
title	The endoplasmic reticulum stress-autophagy pathway controls hypothalamic development and energy balance regulation in leptin-deficient neonates
title_short	The endoplasmic reticulum stress-autophagy pathway controls hypothalamic development and energy balance regulation in leptin-deficient neonates
title_full	The endoplasmic reticulum stress-autophagy pathway controls hypothalamic development and energy balance regulation in leptin-deficient neonates
title_fullStr	The endoplasmic reticulum stress-autophagy pathway controls hypothalamic development and energy balance regulation in leptin-deficient neonates
title_full_unstemmed	The endoplasmic reticulum stress-autophagy pathway controls hypothalamic development and energy balance regulation in leptin-deficient neonates
title_sort	endoplasmic reticulum stress-autophagy pathway controls hypothalamic development and energy balance regulation in leptin-deficient neonates
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/d74405cf600e446290944a2d17d97396
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The endoplasmic reticulum stress-autophagy pathway controls hypothalamic development and energy balance regulation in leptin-deficient neonates

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