Structural insights into TSC complex assembly and GAP activity on Rheb

Structural insights into TSC complex assembly and GAP activity on Rheb

Tuberous sclerosis complex (TSC) regulates cell growth by controlling the activity of mTORC1. The structure of human TSC complex reveals an arch-shaped, asymmetric architecture and a 2:2:1 stoichiometry of TSC1, TSC2, and TBC1D7 subunits and suggests a mechanism by which TSC2 accelerates GTP hydroly...

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Autores principales: Huirong Yang, Zishuo Yu, Xizi Chen, Jiabei Li, Ningning Li, Jiaxuan Cheng, Ning Gao, Hai-Xin Yuan, Dan Ye, Kun-Liang Guan, Yanhui Xu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/d745e4d05ea7420aab143072e24bf771
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spelling oai:doaj.org-article:d745e4d05ea7420aab143072e24bf7712021-12-02T14:12:04ZStructural insights into TSC complex assembly and GAP activity on Rheb10.1038/s41467-020-20522-42041-1723https://doaj.org/article/d745e4d05ea7420aab143072e24bf7712021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20522-4https://doaj.org/toc/2041-1723Tuberous sclerosis complex (TSC) regulates cell growth by controlling the activity of mTORC1. The structure of human TSC complex reveals an arch-shaped, asymmetric architecture and a 2:2:1 stoichiometry of TSC1, TSC2, and TBC1D7 subunits and suggests a mechanism by which TSC2 accelerates GTP hydrolysis against a small GTPase Rheb.Huirong YangZishuo YuXizi ChenJiabei LiNingning LiJiaxuan ChengNing GaoHai-Xin YuanDan YeKun-Liang GuanYanhui XuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Huirong Yang
Zishuo Yu
Xizi Chen
Jiabei Li
Ningning Li
Jiaxuan Cheng
Ning Gao
Hai-Xin Yuan
Dan Ye
Kun-Liang Guan
Yanhui Xu
Structural insights into TSC complex assembly and GAP activity on Rheb
description Tuberous sclerosis complex (TSC) regulates cell growth by controlling the activity of mTORC1. The structure of human TSC complex reveals an arch-shaped, asymmetric architecture and a 2:2:1 stoichiometry of TSC1, TSC2, and TBC1D7 subunits and suggests a mechanism by which TSC2 accelerates GTP hydrolysis against a small GTPase Rheb.
format article
author Huirong Yang
Zishuo Yu
Xizi Chen
Jiabei Li
Ningning Li
Jiaxuan Cheng
Ning Gao
Hai-Xin Yuan
Dan Ye
Kun-Liang Guan
Yanhui Xu
author_facet Huirong Yang
Zishuo Yu
Xizi Chen
Jiabei Li
Ningning Li
Jiaxuan Cheng
Ning Gao
Hai-Xin Yuan
Dan Ye
Kun-Liang Guan
Yanhui Xu
author_sort Huirong Yang
title Structural insights into TSC complex assembly and GAP activity on Rheb
title_short Structural insights into TSC complex assembly and GAP activity on Rheb
title_full Structural insights into TSC complex assembly and GAP activity on Rheb
title_fullStr Structural insights into TSC complex assembly and GAP activity on Rheb
title_full_unstemmed Structural insights into TSC complex assembly and GAP activity on Rheb
title_sort structural insights into tsc complex assembly and gap activity on rheb
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/d745e4d05ea7420aab143072e24bf771
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AT jiabeili structuralinsightsintotsccomplexassemblyandgapactivityonrheb
AT ningningli structuralinsightsintotsccomplexassemblyandgapactivityonrheb
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