Monitoring and detection of leprosy patients in Southwest China: A retrospective study, 2010–2014

Abstract More than 100 counties, mainly in southwest China, report incidence rates of leprosy >1/100,000. The current study analysed the epidemiology of leprosy in southwest China to improve our understanding of the transmission pattern and improve control programs. 207 counties were selected in...

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Autores principales: Wang Le, Jiang Haiqin, Hao Danfeng, Shi Ying, Zhang Wenyue, Yang Jun, Xiong Li, Shui Tiejun, Shen Limei, Liu Jie, Wang De, Ning Yong, Liu Yangying, Wang Hao, Kuang Yanfei, Li Bin, Yumi Maeda, Malcolm Duthie, Yu Meiwen, Wang Hongsheng, Yan Liangbin, Zhang Guocheng, Wang Baoxi, Gu Heng
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Publicado: Nature Portfolio 2018
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spelling oai:doaj.org-article:d74808505d9c44af9495eabf8a3a22fa2021-12-02T11:40:25ZMonitoring and detection of leprosy patients in Southwest China: A retrospective study, 2010–201410.1038/s41598-018-29753-42045-2322https://doaj.org/article/d74808505d9c44af9495eabf8a3a22fa2018-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-29753-4https://doaj.org/toc/2045-2322Abstract More than 100 counties, mainly in southwest China, report incidence rates of leprosy >1/100,000. The current study analysed the epidemiology of leprosy in southwest China to improve our understanding of the transmission pattern and improve control programs. 207 counties were selected in southwest China. Leprosy patients and their household contacts were recruited. The data from the medical interview and the serological antileprosy antibody of the leprosy patients were analysed. A total of 2,353 new cases of leprosy were interviewed. The distribution of leprosy patients was partly associated with local natural and economic conditions, especially several pocket areas. A total of 53 from 6643 household contacts developed leprosy, and the incidence rate of leprosy in the household contacts was 364/100,000 person-years. We found that NDO-BSA attained higher positive rates than MMP-II and LID-1 regardless of clinical types, disability and infection time in leprosy patients. By means of combination of antigens, 88.4% patients of multibacillary leprosy were detected, in contrast to 59.9% in paucibacillary leprosy. Household contacts should be given close attention for the early diagnosis, disruption of disease transmission and precise control. Applications of serology for multi-antigens were recommended for effective coverage and monitoring in leprosy control.Wang LeJiang HaiqinHao DanfengShi YingZhang WenyueYang JunXiong LiShui TiejunShen LimeiLiu JieWang DeNing YongLiu YangyingWang HaoKuang YanfeiLi BinYumi MaedaMalcolm DuthieYu MeiwenWang HongshengYan LiangbinZhang GuochengWang BaoxiGu HengNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Wang Le
Jiang Haiqin
Hao Danfeng
Shi Ying
Zhang Wenyue
Yang Jun
Xiong Li
Shui Tiejun
Shen Limei
Liu Jie
Wang De
Ning Yong
Liu Yangying
Wang Hao
Kuang Yanfei
Li Bin
Yumi Maeda
Malcolm Duthie
Yu Meiwen
Wang Hongsheng
Yan Liangbin
Zhang Guocheng
Wang Baoxi
Gu Heng
Monitoring and detection of leprosy patients in Southwest China: A retrospective study, 2010–2014
description Abstract More than 100 counties, mainly in southwest China, report incidence rates of leprosy >1/100,000. The current study analysed the epidemiology of leprosy in southwest China to improve our understanding of the transmission pattern and improve control programs. 207 counties were selected in southwest China. Leprosy patients and their household contacts were recruited. The data from the medical interview and the serological antileprosy antibody of the leprosy patients were analysed. A total of 2,353 new cases of leprosy were interviewed. The distribution of leprosy patients was partly associated with local natural and economic conditions, especially several pocket areas. A total of 53 from 6643 household contacts developed leprosy, and the incidence rate of leprosy in the household contacts was 364/100,000 person-years. We found that NDO-BSA attained higher positive rates than MMP-II and LID-1 regardless of clinical types, disability and infection time in leprosy patients. By means of combination of antigens, 88.4% patients of multibacillary leprosy were detected, in contrast to 59.9% in paucibacillary leprosy. Household contacts should be given close attention for the early diagnosis, disruption of disease transmission and precise control. Applications of serology for multi-antigens were recommended for effective coverage and monitoring in leprosy control.
format article
author Wang Le
Jiang Haiqin
Hao Danfeng
Shi Ying
Zhang Wenyue
Yang Jun
Xiong Li
Shui Tiejun
Shen Limei
Liu Jie
Wang De
Ning Yong
Liu Yangying
Wang Hao
Kuang Yanfei
Li Bin
Yumi Maeda
Malcolm Duthie
Yu Meiwen
Wang Hongsheng
Yan Liangbin
Zhang Guocheng
Wang Baoxi
Gu Heng
author_facet Wang Le
Jiang Haiqin
Hao Danfeng
Shi Ying
Zhang Wenyue
Yang Jun
Xiong Li
Shui Tiejun
Shen Limei
Liu Jie
Wang De
Ning Yong
Liu Yangying
Wang Hao
Kuang Yanfei
Li Bin
Yumi Maeda
Malcolm Duthie
Yu Meiwen
Wang Hongsheng
Yan Liangbin
Zhang Guocheng
Wang Baoxi
Gu Heng
author_sort Wang Le
title Monitoring and detection of leprosy patients in Southwest China: A retrospective study, 2010–2014
title_short Monitoring and detection of leprosy patients in Southwest China: A retrospective study, 2010–2014
title_full Monitoring and detection of leprosy patients in Southwest China: A retrospective study, 2010–2014
title_fullStr Monitoring and detection of leprosy patients in Southwest China: A retrospective study, 2010–2014
title_full_unstemmed Monitoring and detection of leprosy patients in Southwest China: A retrospective study, 2010–2014
title_sort monitoring and detection of leprosy patients in southwest china: a retrospective study, 2010–2014
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/d74808505d9c44af9495eabf8a3a22fa
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