Monitoring and detection of leprosy patients in Southwest China: A retrospective study, 2010–2014
Abstract More than 100 counties, mainly in southwest China, report incidence rates of leprosy >1/100,000. The current study analysed the epidemiology of leprosy in southwest China to improve our understanding of the transmission pattern and improve control programs. 207 counties were selected in...
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2018
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oai:doaj.org-article:d74808505d9c44af9495eabf8a3a22fa2021-12-02T11:40:25ZMonitoring and detection of leprosy patients in Southwest China: A retrospective study, 2010–201410.1038/s41598-018-29753-42045-2322https://doaj.org/article/d74808505d9c44af9495eabf8a3a22fa2018-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-29753-4https://doaj.org/toc/2045-2322Abstract More than 100 counties, mainly in southwest China, report incidence rates of leprosy >1/100,000. The current study analysed the epidemiology of leprosy in southwest China to improve our understanding of the transmission pattern and improve control programs. 207 counties were selected in southwest China. Leprosy patients and their household contacts were recruited. The data from the medical interview and the serological antileprosy antibody of the leprosy patients were analysed. A total of 2,353 new cases of leprosy were interviewed. The distribution of leprosy patients was partly associated with local natural and economic conditions, especially several pocket areas. A total of 53 from 6643 household contacts developed leprosy, and the incidence rate of leprosy in the household contacts was 364/100,000 person-years. We found that NDO-BSA attained higher positive rates than MMP-II and LID-1 regardless of clinical types, disability and infection time in leprosy patients. By means of combination of antigens, 88.4% patients of multibacillary leprosy were detected, in contrast to 59.9% in paucibacillary leprosy. Household contacts should be given close attention for the early diagnosis, disruption of disease transmission and precise control. Applications of serology for multi-antigens were recommended for effective coverage and monitoring in leprosy control.Wang LeJiang HaiqinHao DanfengShi YingZhang WenyueYang JunXiong LiShui TiejunShen LimeiLiu JieWang DeNing YongLiu YangyingWang HaoKuang YanfeiLi BinYumi MaedaMalcolm DuthieYu MeiwenWang HongshengYan LiangbinZhang GuochengWang BaoxiGu HengNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-8 (2018) |
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DOAJ |
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DOAJ |
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EN |
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Medicine R Science Q |
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Medicine R Science Q Wang Le Jiang Haiqin Hao Danfeng Shi Ying Zhang Wenyue Yang Jun Xiong Li Shui Tiejun Shen Limei Liu Jie Wang De Ning Yong Liu Yangying Wang Hao Kuang Yanfei Li Bin Yumi Maeda Malcolm Duthie Yu Meiwen Wang Hongsheng Yan Liangbin Zhang Guocheng Wang Baoxi Gu Heng Monitoring and detection of leprosy patients in Southwest China: A retrospective study, 2010–2014 |
| description |
Abstract More than 100 counties, mainly in southwest China, report incidence rates of leprosy >1/100,000. The current study analysed the epidemiology of leprosy in southwest China to improve our understanding of the transmission pattern and improve control programs. 207 counties were selected in southwest China. Leprosy patients and their household contacts were recruited. The data from the medical interview and the serological antileprosy antibody of the leprosy patients were analysed. A total of 2,353 new cases of leprosy were interviewed. The distribution of leprosy patients was partly associated with local natural and economic conditions, especially several pocket areas. A total of 53 from 6643 household contacts developed leprosy, and the incidence rate of leprosy in the household contacts was 364/100,000 person-years. We found that NDO-BSA attained higher positive rates than MMP-II and LID-1 regardless of clinical types, disability and infection time in leprosy patients. By means of combination of antigens, 88.4% patients of multibacillary leprosy were detected, in contrast to 59.9% in paucibacillary leprosy. Household contacts should be given close attention for the early diagnosis, disruption of disease transmission and precise control. Applications of serology for multi-antigens were recommended for effective coverage and monitoring in leprosy control. |
| format |
article |
| author |
Wang Le Jiang Haiqin Hao Danfeng Shi Ying Zhang Wenyue Yang Jun Xiong Li Shui Tiejun Shen Limei Liu Jie Wang De Ning Yong Liu Yangying Wang Hao Kuang Yanfei Li Bin Yumi Maeda Malcolm Duthie Yu Meiwen Wang Hongsheng Yan Liangbin Zhang Guocheng Wang Baoxi Gu Heng |
| author_facet |
Wang Le Jiang Haiqin Hao Danfeng Shi Ying Zhang Wenyue Yang Jun Xiong Li Shui Tiejun Shen Limei Liu Jie Wang De Ning Yong Liu Yangying Wang Hao Kuang Yanfei Li Bin Yumi Maeda Malcolm Duthie Yu Meiwen Wang Hongsheng Yan Liangbin Zhang Guocheng Wang Baoxi Gu Heng |
| author_sort |
Wang Le |
| title |
Monitoring and detection of leprosy patients in Southwest China: A retrospective study, 2010–2014 |
| title_short |
Monitoring and detection of leprosy patients in Southwest China: A retrospective study, 2010–2014 |
| title_full |
Monitoring and detection of leprosy patients in Southwest China: A retrospective study, 2010–2014 |
| title_fullStr |
Monitoring and detection of leprosy patients in Southwest China: A retrospective study, 2010–2014 |
| title_full_unstemmed |
Monitoring and detection of leprosy patients in Southwest China: A retrospective study, 2010–2014 |
| title_sort |
monitoring and detection of leprosy patients in southwest china: a retrospective study, 2010–2014 |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/d74808505d9c44af9495eabf8a3a22fa |
| work_keys_str_mv |
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1718395674250182656 |