Clinicopathological and prognostic significance of speckle-type POZ protein in cancers: a systematic review and meta-analysis

Abstract Background Controversial findings have been reported in the impact of speckle-type POZ protein (SPOP) on clinicopathological features and prognosis in diverse cancers. We conducted this meta-analysis to confirm whether SPOP was an effective biomarker to predict clinical stage, cancer differ...

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Autores principales:	Yan He, Jun Chen, Xingchen Peng, Yanli Xia, Yonglin Su
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Speckle-type POZ protein Cancer Biomarker Meta-analysis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Cytology QH573-671
Acceso en línea:	https://doaj.org/article/d74b95125b3e4e56ab0cdce7248bd8e1
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spelling	oai:doaj.org-article:d74b95125b3e4e56ab0cdce7248bd8e12021-11-28T12:37:00ZClinicopathological and prognostic significance of speckle-type POZ protein in cancers: a systematic review and meta-analysis10.1186/s12935-021-02329-51475-2867https://doaj.org/article/d74b95125b3e4e56ab0cdce7248bd8e12021-11-01T00:00:00Zhttps://doi.org/10.1186/s12935-021-02329-5https://doaj.org/toc/1475-2867Abstract Background Controversial findings have been reported in the impact of speckle-type POZ protein (SPOP) on clinicopathological features and prognosis in diverse cancers. We conducted this meta-analysis to confirm whether SPOP was an effective biomarker to predict clinical stage, cancer differentiation and survival. Methods We searched studies published before June 2021 through Medline, Embase, the Cochrane library register of controlled trials and Wanfang databases. The corrections of SPOP expression with expression disparity, tumor differentiation, clinical stage and survival were analyzed. Results Our meta-analysis found that higher expression of SPOP was significantly associated with earlier clinical stage, well differentiation and better overall survival. Subgroup analysis showed that the SPOP expression of adjacent tissue was significantly higher than that in cancer tissues of prostate and liver. However, renal cancer presented improved expression of SPOP in cancer tissue. Conclusions SPOP has the potential function to act as a novel and effective biomarker for cancer diagnosis and prognostic stratification.Yan HeJun ChenXingchen PengYanli XiaYonglin SuBMCarticleSpeckle-type POZ proteinCancerBiomarkerMeta-analysisNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282CytologyQH573-671ENCancer Cell International, Vol 21, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Speckle-type POZ protein Cancer Biomarker Meta-analysis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Cytology QH573-671
spellingShingle	Speckle-type POZ protein Cancer Biomarker Meta-analysis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Cytology QH573-671 Yan He Jun Chen Xingchen Peng Yanli Xia Yonglin Su Clinicopathological and prognostic significance of speckle-type POZ protein in cancers: a systematic review and meta-analysis
description	Abstract Background Controversial findings have been reported in the impact of speckle-type POZ protein (SPOP) on clinicopathological features and prognosis in diverse cancers. We conducted this meta-analysis to confirm whether SPOP was an effective biomarker to predict clinical stage, cancer differentiation and survival. Methods We searched studies published before June 2021 through Medline, Embase, the Cochrane library register of controlled trials and Wanfang databases. The corrections of SPOP expression with expression disparity, tumor differentiation, clinical stage and survival were analyzed. Results Our meta-analysis found that higher expression of SPOP was significantly associated with earlier clinical stage, well differentiation and better overall survival. Subgroup analysis showed that the SPOP expression of adjacent tissue was significantly higher than that in cancer tissues of prostate and liver. However, renal cancer presented improved expression of SPOP in cancer tissue. Conclusions SPOP has the potential function to act as a novel and effective biomarker for cancer diagnosis and prognostic stratification.
format	article
author	Yan He Jun Chen Xingchen Peng Yanli Xia Yonglin Su
author_facet	Yan He Jun Chen Xingchen Peng Yanli Xia Yonglin Su
author_sort	Yan He
title	Clinicopathological and prognostic significance of speckle-type POZ protein in cancers: a systematic review and meta-analysis
title_short	Clinicopathological and prognostic significance of speckle-type POZ protein in cancers: a systematic review and meta-analysis
title_full	Clinicopathological and prognostic significance of speckle-type POZ protein in cancers: a systematic review and meta-analysis
title_fullStr	Clinicopathological and prognostic significance of speckle-type POZ protein in cancers: a systematic review and meta-analysis
title_full_unstemmed	Clinicopathological and prognostic significance of speckle-type POZ protein in cancers: a systematic review and meta-analysis
title_sort	clinicopathological and prognostic significance of speckle-type poz protein in cancers: a systematic review and meta-analysis
publisher	BMC
publishDate	2021
url	https://doaj.org/article/d74b95125b3e4e56ab0cdce7248bd8e1
work_keys_str_mv	AT yanhe clinicopathologicalandprognosticsignificanceofspeckletypepozproteinincancersasystematicreviewandmetaanalysis AT junchen clinicopathologicalandprognosticsignificanceofspeckletypepozproteinincancersasystematicreviewandmetaanalysis AT xingchenpeng clinicopathologicalandprognosticsignificanceofspeckletypepozproteinincancersasystematicreviewandmetaanalysis AT yanlixia clinicopathologicalandprognosticsignificanceofspeckletypepozproteinincancersasystematicreviewandmetaanalysis AT yonglinsu clinicopathologicalandprognosticsignificanceofspeckletypepozproteinincancersasystematicreviewandmetaanalysis
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Clinicopathological and prognostic significance of speckle-type POZ protein in cancers: a systematic review and meta-analysis

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