Prostaglandin in the ventromedial hypothalamus regulates peripheral glucose metabolism

The ventromedial hypothalamus regulates systemic glucose metabolism. Here the authors show that cytosolic phospholipase A2 mediated phospholipid metabolism contributes to this regulation in healthy animals but exert deteriorating effects on glucose homeostasis under high-fat-diet feeding.

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Autores principales: Ming-Liang Lee, Hirokazu Matsunaga, Yuki Sugiura, Takahiro Hayasaka, Izumi Yamamoto, Taiga Ishimoto, Daigo Imoto, Makoto Suematsu, Norifumi Iijima, Kazuhiro Kimura, Sabrina Diano, Chitoku Toda
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/d75bb48442764a558ebec50556d76a3e
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spelling oai:doaj.org-article:d75bb48442764a558ebec50556d76a3e2021-12-02T13:39:22ZProstaglandin in the ventromedial hypothalamus regulates peripheral glucose metabolism10.1038/s41467-021-22431-62041-1723https://doaj.org/article/d75bb48442764a558ebec50556d76a3e2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22431-6https://doaj.org/toc/2041-1723The ventromedial hypothalamus regulates systemic glucose metabolism. Here the authors show that cytosolic phospholipase A2 mediated phospholipid metabolism contributes to this regulation in healthy animals but exert deteriorating effects on glucose homeostasis under high-fat-diet feeding.Ming-Liang LeeHirokazu MatsunagaYuki SugiuraTakahiro HayasakaIzumi YamamotoTaiga IshimotoDaigo ImotoMakoto SuematsuNorifumi IijimaKazuhiro KimuraSabrina DianoChitoku TodaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Ming-Liang Lee
Hirokazu Matsunaga
Yuki Sugiura
Takahiro Hayasaka
Izumi Yamamoto
Taiga Ishimoto
Daigo Imoto
Makoto Suematsu
Norifumi Iijima
Kazuhiro Kimura
Sabrina Diano
Chitoku Toda
Prostaglandin in the ventromedial hypothalamus regulates peripheral glucose metabolism
description The ventromedial hypothalamus regulates systemic glucose metabolism. Here the authors show that cytosolic phospholipase A2 mediated phospholipid metabolism contributes to this regulation in healthy animals but exert deteriorating effects on glucose homeostasis under high-fat-diet feeding.
format article
author Ming-Liang Lee
Hirokazu Matsunaga
Yuki Sugiura
Takahiro Hayasaka
Izumi Yamamoto
Taiga Ishimoto
Daigo Imoto
Makoto Suematsu
Norifumi Iijima
Kazuhiro Kimura
Sabrina Diano
Chitoku Toda
author_facet Ming-Liang Lee
Hirokazu Matsunaga
Yuki Sugiura
Takahiro Hayasaka
Izumi Yamamoto
Taiga Ishimoto
Daigo Imoto
Makoto Suematsu
Norifumi Iijima
Kazuhiro Kimura
Sabrina Diano
Chitoku Toda
author_sort Ming-Liang Lee
title Prostaglandin in the ventromedial hypothalamus regulates peripheral glucose metabolism
title_short Prostaglandin in the ventromedial hypothalamus regulates peripheral glucose metabolism
title_full Prostaglandin in the ventromedial hypothalamus regulates peripheral glucose metabolism
title_fullStr Prostaglandin in the ventromedial hypothalamus regulates peripheral glucose metabolism
title_full_unstemmed Prostaglandin in the ventromedial hypothalamus regulates peripheral glucose metabolism
title_sort prostaglandin in the ventromedial hypothalamus regulates peripheral glucose metabolism
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/d75bb48442764a558ebec50556d76a3e
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