The Intervention and Mechanism of Action for Aloin against Subchronic Aflatoxin B1 Induced Hepatic Injury in Rats

As a class of difurancoumarin compounds with similar structures, aflatoxins (AF) are commonly found in the environment, soil, and food crops. AF pose a serious threat to the health of humans, poultry, and livestock. This study aimed to investigate the neuroprotective effect and detailed mechanism of...

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Autores principales: Hanyi Hua, Jie Sheng, Yan Cui, Wenyi Zhang, Bin Hu, Yuliang Cheng, Yahui Guo, He Qian
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Publicado: MDPI AG 2021
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spelling oai:doaj.org-article:d75dad1ad5394391981f1cb059da39692021-11-11T17:05:59ZThe Intervention and Mechanism of Action for Aloin against Subchronic Aflatoxin B1 Induced Hepatic Injury in Rats10.3390/ijms2221116201422-00671661-6596https://doaj.org/article/d75dad1ad5394391981f1cb059da39692021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11620https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067As a class of difurancoumarin compounds with similar structures, aflatoxins (AF) are commonly found in the environment, soil, and food crops. AF pose a serious threat to the health of humans, poultry, and livestock. This study aimed to investigate the neuroprotective effect and detailed mechanism of aloin on hepatic injury induced by subchronic AFB1 in rats. The result showed that aloin could significantly inhibit the decrease in food intake, body weight growth, immune organ index, and serum albumin content caused by long-term AFB1 exposure. Meanwhile, aloin reduced the level of serum liver function and improved renal swelling and pathological changes of liver tissue. Aloin could also inhibit liver lipid peroxidation and improve liver antioxidant capacity. Further investigation revealed that aloin inhibited the activity and expression of hepatic CYP1A2 and CYP3A4 and down-regulated <i>IL-1β</i> expression in subchronic AFB1-induced liver injury rats. The above study demonstrated that aloin played an important role in blocking or delaying the development process of subchronic AFB1-induced hepatotoxicity. Therefore, aloin is considered to have a potential role as a protective agent against AFB1.Hanyi HuaJie ShengYan CuiWenyi ZhangBin HuYuliang ChengYahui GuoHe QianMDPI AGarticleaflatoxinsAFB1CYP1A2CYP3A4aloinBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11620, p 11620 (2021)
institution DOAJ
collection DOAJ
language EN
topic aflatoxins
AFB1
CYP1A2
CYP3A4
aloin
Biology (General)
QH301-705.5
Chemistry
QD1-999
spellingShingle aflatoxins
AFB1
CYP1A2
CYP3A4
aloin
Biology (General)
QH301-705.5
Chemistry
QD1-999
Hanyi Hua
Jie Sheng
Yan Cui
Wenyi Zhang
Bin Hu
Yuliang Cheng
Yahui Guo
He Qian
The Intervention and Mechanism of Action for Aloin against Subchronic Aflatoxin B1 Induced Hepatic Injury in Rats
description As a class of difurancoumarin compounds with similar structures, aflatoxins (AF) are commonly found in the environment, soil, and food crops. AF pose a serious threat to the health of humans, poultry, and livestock. This study aimed to investigate the neuroprotective effect and detailed mechanism of aloin on hepatic injury induced by subchronic AFB1 in rats. The result showed that aloin could significantly inhibit the decrease in food intake, body weight growth, immune organ index, and serum albumin content caused by long-term AFB1 exposure. Meanwhile, aloin reduced the level of serum liver function and improved renal swelling and pathological changes of liver tissue. Aloin could also inhibit liver lipid peroxidation and improve liver antioxidant capacity. Further investigation revealed that aloin inhibited the activity and expression of hepatic CYP1A2 and CYP3A4 and down-regulated <i>IL-1β</i> expression in subchronic AFB1-induced liver injury rats. The above study demonstrated that aloin played an important role in blocking or delaying the development process of subchronic AFB1-induced hepatotoxicity. Therefore, aloin is considered to have a potential role as a protective agent against AFB1.
format article
author Hanyi Hua
Jie Sheng
Yan Cui
Wenyi Zhang
Bin Hu
Yuliang Cheng
Yahui Guo
He Qian
author_facet Hanyi Hua
Jie Sheng
Yan Cui
Wenyi Zhang
Bin Hu
Yuliang Cheng
Yahui Guo
He Qian
author_sort Hanyi Hua
title The Intervention and Mechanism of Action for Aloin against Subchronic Aflatoxin B1 Induced Hepatic Injury in Rats
title_short The Intervention and Mechanism of Action for Aloin against Subchronic Aflatoxin B1 Induced Hepatic Injury in Rats
title_full The Intervention and Mechanism of Action for Aloin against Subchronic Aflatoxin B1 Induced Hepatic Injury in Rats
title_fullStr The Intervention and Mechanism of Action for Aloin against Subchronic Aflatoxin B1 Induced Hepatic Injury in Rats
title_full_unstemmed The Intervention and Mechanism of Action for Aloin against Subchronic Aflatoxin B1 Induced Hepatic Injury in Rats
title_sort intervention and mechanism of action for aloin against subchronic aflatoxin b1 induced hepatic injury in rats
publisher MDPI AG
publishDate 2021
url https://doaj.org/article/d75dad1ad5394391981f1cb059da3969
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