Crystal structures of the NO sensor NsrR reveal how its iron-sulfur cluster modulates DNA binding

NsrR is a bacterial transcriptional regulator that acts as a nitric oxide (NO) sensor. Here, the authors present the crystal structure of NsrR, which reveals an unusual Fe-S cluster coordination and explains how NO exposure leads to the degradation of the cluster.

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Autores principales:	Anne Volbeda, Erin L. Dodd, Claudine Darnault, Jason C. Crack, Oriane Renoux, Matthew I. Hutchings, Nick E. Le Brun, Juan C. Fontecilla-Camps
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d75fcbfde85945c6bdbb68596b935661
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spelling	oai:doaj.org-article:d75fcbfde85945c6bdbb68596b9356612021-12-02T15:38:57ZCrystal structures of the NO sensor NsrR reveal how its iron-sulfur cluster modulates DNA binding10.1038/ncomms150522041-1723https://doaj.org/article/d75fcbfde85945c6bdbb68596b9356612017-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms15052https://doaj.org/toc/2041-1723NsrR is a bacterial transcriptional regulator that acts as a nitric oxide (NO) sensor. Here, the authors present the crystal structure of NsrR, which reveals an unusual Fe-S cluster coordination and explains how NO exposure leads to the degradation of the cluster.Anne VolbedaErin L. DoddClaudine DarnaultJason C. CrackOriane RenouxMatthew I. HutchingsNick E. Le BrunJuan C. Fontecilla-CampsNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Anne Volbeda Erin L. Dodd Claudine Darnault Jason C. Crack Oriane Renoux Matthew I. Hutchings Nick E. Le Brun Juan C. Fontecilla-Camps Crystal structures of the NO sensor NsrR reveal how its iron-sulfur cluster modulates DNA binding
description	NsrR is a bacterial transcriptional regulator that acts as a nitric oxide (NO) sensor. Here, the authors present the crystal structure of NsrR, which reveals an unusual Fe-S cluster coordination and explains how NO exposure leads to the degradation of the cluster.
format	article
author	Anne Volbeda Erin L. Dodd Claudine Darnault Jason C. Crack Oriane Renoux Matthew I. Hutchings Nick E. Le Brun Juan C. Fontecilla-Camps
author_facet	Anne Volbeda Erin L. Dodd Claudine Darnault Jason C. Crack Oriane Renoux Matthew I. Hutchings Nick E. Le Brun Juan C. Fontecilla-Camps
author_sort	Anne Volbeda
title	Crystal structures of the NO sensor NsrR reveal how its iron-sulfur cluster modulates DNA binding
title_short	Crystal structures of the NO sensor NsrR reveal how its iron-sulfur cluster modulates DNA binding
title_full	Crystal structures of the NO sensor NsrR reveal how its iron-sulfur cluster modulates DNA binding
title_fullStr	Crystal structures of the NO sensor NsrR reveal how its iron-sulfur cluster modulates DNA binding
title_full_unstemmed	Crystal structures of the NO sensor NsrR reveal how its iron-sulfur cluster modulates DNA binding
title_sort	crystal structures of the no sensor nsrr reveal how its iron-sulfur cluster modulates dna binding
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/d75fcbfde85945c6bdbb68596b935661
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Crystal structures of the NO sensor NsrR reveal how its iron-sulfur cluster modulates DNA binding

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