Comparative Analysis of Salivary Mycobiome Diversity in Human Immunodeficiency Virus-Infected Patients

Reports on alterations in the oral mycobiome of HIV-infected patients are still limited. This study was designed to compare the salivary mycobiome between 30 human immunodeficiency virus (HIV) infections and 30 healthy controls and explore the effect of antiretroviral therapy (ART) administration on...

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Autores principales:	Shenghua Chang, Haiying Guo, Jin Li, Yaoting Ji, Han Jiang, Lianguo Ruan, Minquan Du
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	saliva salivary mycobiome human immunodeficiency virus antiretroviral therapy high-throughput sequencing Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/d76139e81ed0451e9876bad0ba92e1ab
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spelling	oai:doaj.org-article:d76139e81ed0451e9876bad0ba92e1ab2021-12-01T22:11:19ZComparative Analysis of Salivary Mycobiome Diversity in Human Immunodeficiency Virus-Infected Patients2235-298810.3389/fcimb.2021.781246https://doaj.org/article/d76139e81ed0451e9876bad0ba92e1ab2021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcimb.2021.781246/fullhttps://doaj.org/toc/2235-2988Reports on alterations in the oral mycobiome of HIV-infected patients are still limited. This study was designed to compare the salivary mycobiome between 30 human immunodeficiency virus (HIV) infections and 30 healthy controls and explore the effect of antiretroviral therapy (ART) administration on the oral mycobiome of HIV infections. Results showed that the diversity and richness of salivary mycobiome in HIV-infected individuals were higher than those of controls (P < 0.05). After ART, the diversity and richness of salivary mycobiome in HIV-infected patients were reduced significantly (P < 0.05). Candida, Mortierella, Malassezia, Simplicillium, and Penicillium were significantly enriched in the HIV group and dramatically decreased after ART. While the relative abundance of Verticillium, Issatchenkia, and Alternaria significantly increased in patients with HIV after ART. Correlation analysis revealed that Mortierella, Malassezia, Simplicillium, and Chaetomium were positively correlated with viral load (VL), whereas Thyrostroma and Archaeorhizomyces were negatively related to VL and positively related to CD4+ T-cell counts. All results showed that HIV infection and ART administration affected the composition of salivary mycobiome communities. Furthermore, differences of salivary mycobiome in HIV infections after ART were complex and might mirror the immune state of the body.Shenghua ChangHaiying GuoJin LiYaoting JiHan JiangLianguo RuanMinquan DuFrontiers Media S.A.articlesalivasalivary mycobiomehuman immunodeficiency virusantiretroviral therapyhigh-throughput sequencingMicrobiologyQR1-502ENFrontiers in Cellular and Infection Microbiology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	saliva salivary mycobiome human immunodeficiency virus antiretroviral therapy high-throughput sequencing Microbiology QR1-502
spellingShingle	saliva salivary mycobiome human immunodeficiency virus antiretroviral therapy high-throughput sequencing Microbiology QR1-502 Shenghua Chang Haiying Guo Jin Li Yaoting Ji Han Jiang Lianguo Ruan Minquan Du Comparative Analysis of Salivary Mycobiome Diversity in Human Immunodeficiency Virus-Infected Patients
description	Reports on alterations in the oral mycobiome of HIV-infected patients are still limited. This study was designed to compare the salivary mycobiome between 30 human immunodeficiency virus (HIV) infections and 30 healthy controls and explore the effect of antiretroviral therapy (ART) administration on the oral mycobiome of HIV infections. Results showed that the diversity and richness of salivary mycobiome in HIV-infected individuals were higher than those of controls (P < 0.05). After ART, the diversity and richness of salivary mycobiome in HIV-infected patients were reduced significantly (P < 0.05). Candida, Mortierella, Malassezia, Simplicillium, and Penicillium were significantly enriched in the HIV group and dramatically decreased after ART. While the relative abundance of Verticillium, Issatchenkia, and Alternaria significantly increased in patients with HIV after ART. Correlation analysis revealed that Mortierella, Malassezia, Simplicillium, and Chaetomium were positively correlated with viral load (VL), whereas Thyrostroma and Archaeorhizomyces were negatively related to VL and positively related to CD4+ T-cell counts. All results showed that HIV infection and ART administration affected the composition of salivary mycobiome communities. Furthermore, differences of salivary mycobiome in HIV infections after ART were complex and might mirror the immune state of the body.
format	article
author	Shenghua Chang Haiying Guo Jin Li Yaoting Ji Han Jiang Lianguo Ruan Minquan Du
author_facet	Shenghua Chang Haiying Guo Jin Li Yaoting Ji Han Jiang Lianguo Ruan Minquan Du
author_sort	Shenghua Chang
title	Comparative Analysis of Salivary Mycobiome Diversity in Human Immunodeficiency Virus-Infected Patients
title_short	Comparative Analysis of Salivary Mycobiome Diversity in Human Immunodeficiency Virus-Infected Patients
title_full	Comparative Analysis of Salivary Mycobiome Diversity in Human Immunodeficiency Virus-Infected Patients
title_fullStr	Comparative Analysis of Salivary Mycobiome Diversity in Human Immunodeficiency Virus-Infected Patients
title_full_unstemmed	Comparative Analysis of Salivary Mycobiome Diversity in Human Immunodeficiency Virus-Infected Patients
title_sort	comparative analysis of salivary mycobiome diversity in human immunodeficiency virus-infected patients
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/d76139e81ed0451e9876bad0ba92e1ab
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Comparative Analysis of Salivary Mycobiome Diversity in Human Immunodeficiency Virus-Infected Patients

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