3-Hydroxy-5,6-epoxy-β-ionone Isolated from Invasive Harmful Brown Seaweed Sargassum Horneri Protects MH-S Mouse Lung Cells from Urban Particulate Matter-Induced Inflammation

Air pollution is a process that mixes pollutants into the atmosphere, which is potentially harmful to humans and causes negative impacts on the surrounding environment (biotic and abiotic). The negative health effects associated with air pollution have been reported from both indoor and outdoor envi...

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Autores principales:	K. K. Asanka Sanjeewa, Hyun-Soo Kim, Hyo-Geun Lee, Thilina U. Jayawardena, D. P. Nagahawatta, Hye-Won Yang, Dhanushka Udayanga, Jae-Il Kim, You-Jin Jeon
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	lung macrophages inflammation oxidative stress <i>Sargassum horneri</i> particulate matter Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/d763e776c210454b891e09af3b64a01e
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spelling	oai:doaj.org-article:d763e776c210454b891e09af3b64a01e2021-11-25T16:41:13Z3-Hydroxy-5,6-epoxy-β-ionone Isolated from Invasive Harmful Brown Seaweed Sargassum Horneri Protects MH-S Mouse Lung Cells from Urban Particulate Matter-Induced Inflammation10.3390/app1122109292076-3417https://doaj.org/article/d763e776c210454b891e09af3b64a01e2021-11-01T00:00:00Zhttps://www.mdpi.com/2076-3417/11/22/10929https://doaj.org/toc/2076-3417Air pollution is a process that mixes pollutants into the atmosphere, which is potentially harmful to humans and causes negative impacts on the surrounding environment (biotic and abiotic). The negative health effects associated with air pollution have been reported from both indoor and outdoor environments. Specifically, dust storms originating in Chinese and Mongolian desert areas introduce significant amounts of particulate matter (PM) to the Korean atmosphere. Previously, several studies reported that urban PM (UPM) is a potential agent that causes inflammation in the lungs by altering multiple signal transduction pathways; therefore, screening and identification of anti-inflammatory compounds against UPM-induced inflammation is an urgent requirement. In the present study, we attempted to study the anti-inflammatory properties of 3-Hydroxy-5,6-epoxy-β-ionone (HEBI), a pure compound isolated from invasive brown seaweed, <i>Sargassum horneri</i> (brown edible seaweed), against UPM-stimulated lung macrophages (MH-S). Anti-inflammatory parameters of HEBI were evaluated using Western blots, ELISA, RT-qPCR, and MTT assays. According to the results, HEBI at concentrations between 31.3 and 125 µg/mL reduced UPM-induced NO, PGE2, and pro-inflammatory cytokine production via blocking the downstream signal transduction of NF-κB and MAPKs. Specifically, HEBI down-regulated the mRNA expression levels of Toll-like receptors 2 and 4, which are well-known NF-κB and MAPKs stimulators. Taken together, HEBI is a potential candidate to develop functional foods and active ingredients in cosmeceuticals because of its profound effects against UPM-induced inflammation in MH-S macrophages.K. K. Asanka SanjeewaHyun-Soo KimHyo-Geun LeeThilina U. JayawardenaD. P. NagahawattaHye-Won YangDhanushka UdayangaJae-Il KimYou-Jin JeonMDPI AGarticlelung macrophagesinflammationoxidative stress<i>Sargassum horneri</i>particulate matterTechnologyTEngineering (General). Civil engineering (General)TA1-2040Biology (General)QH301-705.5PhysicsQC1-999ChemistryQD1-999ENApplied Sciences, Vol 11, Iss 10929, p 10929 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	lung macrophages inflammation oxidative stress <i>Sargassum horneri</i> particulate matter Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
spellingShingle	lung macrophages inflammation oxidative stress <i>Sargassum horneri</i> particulate matter Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999 K. K. Asanka Sanjeewa Hyun-Soo Kim Hyo-Geun Lee Thilina U. Jayawardena D. P. Nagahawatta Hye-Won Yang Dhanushka Udayanga Jae-Il Kim You-Jin Jeon 3-Hydroxy-5,6-epoxy-β-ionone Isolated from Invasive Harmful Brown Seaweed Sargassum Horneri Protects MH-S Mouse Lung Cells from Urban Particulate Matter-Induced Inflammation
description	Air pollution is a process that mixes pollutants into the atmosphere, which is potentially harmful to humans and causes negative impacts on the surrounding environment (biotic and abiotic). The negative health effects associated with air pollution have been reported from both indoor and outdoor environments. Specifically, dust storms originating in Chinese and Mongolian desert areas introduce significant amounts of particulate matter (PM) to the Korean atmosphere. Previously, several studies reported that urban PM (UPM) is a potential agent that causes inflammation in the lungs by altering multiple signal transduction pathways; therefore, screening and identification of anti-inflammatory compounds against UPM-induced inflammation is an urgent requirement. In the present study, we attempted to study the anti-inflammatory properties of 3-Hydroxy-5,6-epoxy-β-ionone (HEBI), a pure compound isolated from invasive brown seaweed, <i>Sargassum horneri</i> (brown edible seaweed), against UPM-stimulated lung macrophages (MH-S). Anti-inflammatory parameters of HEBI were evaluated using Western blots, ELISA, RT-qPCR, and MTT assays. According to the results, HEBI at concentrations between 31.3 and 125 µg/mL reduced UPM-induced NO, PGE2, and pro-inflammatory cytokine production via blocking the downstream signal transduction of NF-κB and MAPKs. Specifically, HEBI down-regulated the mRNA expression levels of Toll-like receptors 2 and 4, which are well-known NF-κB and MAPKs stimulators. Taken together, HEBI is a potential candidate to develop functional foods and active ingredients in cosmeceuticals because of its profound effects against UPM-induced inflammation in MH-S macrophages.
format	article
author	K. K. Asanka Sanjeewa Hyun-Soo Kim Hyo-Geun Lee Thilina U. Jayawardena D. P. Nagahawatta Hye-Won Yang Dhanushka Udayanga Jae-Il Kim You-Jin Jeon
author_facet	K. K. Asanka Sanjeewa Hyun-Soo Kim Hyo-Geun Lee Thilina U. Jayawardena D. P. Nagahawatta Hye-Won Yang Dhanushka Udayanga Jae-Il Kim You-Jin Jeon
author_sort	K. K. Asanka Sanjeewa
title	3-Hydroxy-5,6-epoxy-β-ionone Isolated from Invasive Harmful Brown Seaweed Sargassum Horneri Protects MH-S Mouse Lung Cells from Urban Particulate Matter-Induced Inflammation
title_short	3-Hydroxy-5,6-epoxy-β-ionone Isolated from Invasive Harmful Brown Seaweed Sargassum Horneri Protects MH-S Mouse Lung Cells from Urban Particulate Matter-Induced Inflammation
title_full	3-Hydroxy-5,6-epoxy-β-ionone Isolated from Invasive Harmful Brown Seaweed Sargassum Horneri Protects MH-S Mouse Lung Cells from Urban Particulate Matter-Induced Inflammation
title_fullStr	3-Hydroxy-5,6-epoxy-β-ionone Isolated from Invasive Harmful Brown Seaweed Sargassum Horneri Protects MH-S Mouse Lung Cells from Urban Particulate Matter-Induced Inflammation
title_full_unstemmed	3-Hydroxy-5,6-epoxy-β-ionone Isolated from Invasive Harmful Brown Seaweed Sargassum Horneri Protects MH-S Mouse Lung Cells from Urban Particulate Matter-Induced Inflammation
title_sort	3-hydroxy-5,6-epoxy-β-ionone isolated from invasive harmful brown seaweed sargassum horneri protects mh-s mouse lung cells from urban particulate matter-induced inflammation
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/d763e776c210454b891e09af3b64a01e
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3-Hydroxy-5,6-epoxy-β-ionone Isolated from Invasive Harmful Brown Seaweed Sargassum Horneri Protects MH-S Mouse Lung Cells from Urban Particulate Matter-Induced Inflammation

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