Large-scale simulations of biological cell sorting driven by differential adhesion follow diffusion-limited domain coalescence regime.

Cell sorting, whereby a heterogeneous cell mixture segregates and forms distinct homogeneous tissues, is one of the main collective cell behaviors at work during development. Although differences in interfacial energies are recognized to be a possible driving source for cell sorting, no clear consen...

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Autor principal:	Marc Durand
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/d7691bf5317f4549ae29a0504f5662bb
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spelling	oai:doaj.org-article:d7691bf5317f4549ae29a0504f5662bb2021-12-02T19:58:04ZLarge-scale simulations of biological cell sorting driven by differential adhesion follow diffusion-limited domain coalescence regime.1553-734X1553-735810.1371/journal.pcbi.1008576https://doaj.org/article/d7691bf5317f4549ae29a0504f5662bb2021-08-01T00:00:00Zhttps://doi.org/10.1371/journal.pcbi.1008576https://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358Cell sorting, whereby a heterogeneous cell mixture segregates and forms distinct homogeneous tissues, is one of the main collective cell behaviors at work during development. Although differences in interfacial energies are recognized to be a possible driving source for cell sorting, no clear consensus has emerged on the kinetic law of cell sorting driven by differential adhesion. Using a modified Cellular Potts Model algorithm that allows for efficient simulations while preserving the connectivity of cells, we numerically explore cell-sorting dynamics over very large scales in space and time. For a binary mixture of cells surrounded by a medium, increase of domain size follows a power-law with exponent n = 1/4 independently of the mixture ratio, revealing that the kinetics is dominated by the diffusion and coalescence of rounded domains. We compare these results with recent numerical studies on cell sorting, and discuss the importance of algorithmic differences as well as boundary conditions on the observed scaling.Marc DurandPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 17, Iss 8, p e1008576 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Marc Durand Large-scale simulations of biological cell sorting driven by differential adhesion follow diffusion-limited domain coalescence regime.
description	Cell sorting, whereby a heterogeneous cell mixture segregates and forms distinct homogeneous tissues, is one of the main collective cell behaviors at work during development. Although differences in interfacial energies are recognized to be a possible driving source for cell sorting, no clear consensus has emerged on the kinetic law of cell sorting driven by differential adhesion. Using a modified Cellular Potts Model algorithm that allows for efficient simulations while preserving the connectivity of cells, we numerically explore cell-sorting dynamics over very large scales in space and time. For a binary mixture of cells surrounded by a medium, increase of domain size follows a power-law with exponent n = 1/4 independently of the mixture ratio, revealing that the kinetics is dominated by the diffusion and coalescence of rounded domains. We compare these results with recent numerical studies on cell sorting, and discuss the importance of algorithmic differences as well as boundary conditions on the observed scaling.
format	article
author	Marc Durand
author_facet	Marc Durand
author_sort	Marc Durand
title	Large-scale simulations of biological cell sorting driven by differential adhesion follow diffusion-limited domain coalescence regime.
title_short	Large-scale simulations of biological cell sorting driven by differential adhesion follow diffusion-limited domain coalescence regime.
title_full	Large-scale simulations of biological cell sorting driven by differential adhesion follow diffusion-limited domain coalescence regime.
title_fullStr	Large-scale simulations of biological cell sorting driven by differential adhesion follow diffusion-limited domain coalescence regime.
title_full_unstemmed	Large-scale simulations of biological cell sorting driven by differential adhesion follow diffusion-limited domain coalescence regime.
title_sort	large-scale simulations of biological cell sorting driven by differential adhesion follow diffusion-limited domain coalescence regime.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/d7691bf5317f4549ae29a0504f5662bb
work_keys_str_mv	AT marcdurand largescalesimulationsofbiologicalcellsortingdrivenbydifferentialadhesionfollowdiffusionlimiteddomaincoalescenceregime
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Large-scale simulations of biological cell sorting driven by differential adhesion follow diffusion-limited domain coalescence regime.

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